Neuropsychopharmacology. 2013 Sep 26. doi: 10.1038 / npp.2013.255.
Dietz DM, Kennedy PJ, Sun H, Maze I, Gancarz AM, Vialou V, Koo J, Mouzon E, Gose S, Tamminga CA, Nestler EJ.
source
1]
Fishberg Department of Neuroscience iyo Friedman Brain Institute, Icahn
Iskuulka Caafimaadka ee Mount Siinaay, Hal Gustave L. Levy Place, New York,
NY, USA [2] Waaxda Farmashiyaha iyo Toxicology iyo Machadka on
Qabatinka, Jaamacada Buffalo, Buffalo, New York, USA.
aan la taaban karin
ΔFosB, oo ah waxsoosaarka hiddo-wadaha ee 'FosB', ayaa lagu kallifay kortexka hore ee cudurka maskaxda (PFC) iyadoo la adeegsanayo soo-noqnoqoshada dhowr dhiirrigelin oo ay ka mid yihiin dawooyinka loo yaqaan 'antipsychotictic sida haloperidol'. Si kastaba ha noqotee, cawaaqibka firfircoon ee muujinta ΔFosB ee soo kordha ka dib daaweynta daaweynta qalliinka 'lama sahamin. Halkan, waxaan ku qiimeynay haddii duFosB induction by haloperidol ay dhexdhexaadinayso cawaaqib xumada ama waxtarka daaweynta ee daaweynta antipsychotic. Waxaan soo bandhignay in shakhsiyaadka qaba shisoofrani ee lagu daaweeyay dawooyinka loo yaqaan 'antipsychotic' waqtiga dhimashadooda ay muujinayaan kororka heerarka osFosB ee PFC, taasoo ah saameynta ka dhalata jiirka ee si joogto ah loola dhaqmo haloperidol. Taa bedelkeeda, shakhsiyaadka qaba shisoofrani ee aan dawada lahayn ayaan soo bandhigin saameyntaan. Xad-gudub dhexdhexaad ah oo dhexdhexaad ah oo ah 'FosB' ee PFC ee jiirka ayaa ku yaraaday cilladaha garashada sida lagu cabbiray iska ilaalinta, kordhinta jawaabaha bilowga ah ee howlaha PPI, iyo kordhinta dabeecadaha walaaca-la mid ah ee MK-801. Isku soo wada duuboo, natiijooyinkaani waxay soo jeedinayaan in 'FosB induction in PFC ee daaweynta antipsychotic ay gacan ka geysaneyso saameynta tirtirma ee daawooyinkaan oo aan ku jirin talaabooyinkooda daaweynta .Neuropsychopharmacology waxay aqbashay maqaalka horudhaca ah ee khadka tooska ah, 26 Sebtember 2013. doi: 10.1038 / npp.2013.255.
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