J Neurochem. 2010 Jul; 114 (2): 475-87. doi: 10.1111 / j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
Núñez C1, Martín F, Földes A, Luisa Laorden M, Kovács KJ, Victoria Milanés M.
- 1Department of Pharmacology, Jaamacadda Takhaatiirta, Murcia, Spain. [emailka waa la ilaaliyay]
aan la taaban karin
Xaaladda isbeddelka loo yaqaan 'DeltaFosB' ayaa lagu soo rogay nambarada nucleus (NAc) ee daroogooyinka xadgudubka. Daraasaddan waxaa loogu talagalay in lagu qiimeeyo isbedelka suurtagalka ah ee FosB / DeltaFosB ee labadaba hypothalamic iyo extrahypothalamic nidaamka cadaadiska maskaxda inta lagu jiro xaddiga morphine iyo ka bixitaanka.
Jiirka waxaa lagu sameeyay maadada morphine iyo, maalinta 8, lagu duray saline ama naloxone. Iyadoo la adeegsanayo immunohistochemistry iyo galbeedka galbeed, muujinta FosB / DeltaFosB, tyrosine hydroxylase (TH), Corticotropin-releasing factor (CRF) iyo pro-dynorphin (DYN) ayaa lagu qiyaasey nuclei kala duwan oo ka yimid nidaamka cadaadiska maskaxda ee jiirka miyirka iyo ka dib morphine ka bax. Intaa waxaa dheer, waxaan ku darsannay fosbol / DeltaFosB ee CRF-, TH- iyo DYN-nuucyada wanaagsan. FosB / DeltaFosB waxaa lagu soo bandhigay ka dib markii miyir-beelka dabiiciga ah ee mitrooga loo yaqaan 'morphine' oo ku yaal qaybta hoose ee hypothalamic nucleus (PVN), NAc-shell, qudaarta sariirta ee terminaalka stria, central amygdala iyo A (2) ee noradrenergic qaybta nucleus tractus solitarius (NTS- A (2)). Maqnaanshaha Morphine iyo ka noqoshada ayaa kor u qaadey korodhka FosB / DeltaFosB-TH iyo FosB / DeltaFosB-CRF labajibaarista NTS-A (2) iyo PVN, siday u kala horreeyaan, marka lagu daro kororka heerarka TH ee NTS-A (2) iyo muujinta CRF PVN.
Xogtaasi waxay muujineysaa in nuujinta loo adeegsado walxaha la qabatimay, oo loo arkay inay isku soo uruuriyeen FosB / DeltaFosB, kuma koobna wareegyada abaalmarinta laakiin waxay sidoo kale muujin kartaa gobollada kale ee maskaxda, sida nidaamka cadaadiska maskaxda, oo loo soo jeediyay inay si toos ah ula xidhiidhaan xatooyada .
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