Maandooriye. 2013 May; 108 (5): 953-63. doi: 10.1111 / add.12066. Epub 2013 Jan 3.
Boileau I, Bixiyaha D, Chugani B, Lobo D, Behzadi A, Rusjan PM, Houle S, Wilson AA, Warsh J, Kish SJ, Zack M.
source
Kooxda Cilmi-baarista Sawir-qaadista, Xarun Ku-Meel-Gaarka iyo Caafimaadka Maskaxda, Toronto, ON, Canada. [emailka waa la ilaaliyay]
aan la taaban karin
AIMS:
Khamaarka nafsadda (PG) wuxuu muujinayaa sifooyinka baaritaanka isticmaalka maandooriyaha (SUD), laakiin hababka neerojiga ee hoos yimaada PG si xun ayaa loo fahmay. Sababtoo ah dopamine (DA), neurotransmitter waxa uu ku jiraa abaalmarinta iyo xoojinta, waxaa laga yaabaa inay lug ku yeeshaan, waxaan isticmaalnay sawirro xasaasiyadeed oo xasilooni ah (PET) si loo baaro in PG uu ku xiran yahay isbeddellada heerarka qiyaasaha D2 iyo D3, sida lagu arkay SUD.
Design:
Daraasad xakamaynta kiisaska la barbardhigo PG ilaa maaraynta caafimaadka leh (HC).
Dejinta:
Xarunta sawir-baadhista ee waxbarashada.
BARTAMAHA:
Saddex iyo toban dumar ah oo aan daweynin oo la kulma shuruudaha DSM-IV ee loogu talagalay PG, iyo 12 waxay la midoobeen HC (11 oo ka mid ah PET).
QIIMAHA:
Laba sawir oo PET ah (mid ka mid ah daaweeye D3 oo doorbidaya agonist [11C] - (+) - propyl-hexahydro-naphtho-oxazin (PHNO) iyo tan kale [11C] raclopride) si loo qiimeeyo helitaanka D (2 / 3) DA, iyo tallaabooyinka habdhaqanka (iskuduwaha sua'al-celinta iyo gawaarida mashiinka mashiinka) si loo qiimeeyo saameynaha shucuurta iyo xiriirka ka dhaxeeya tallaabooyinka PET.
NATIIJOOYINKA:
Xiritaanka labada raadiyeyaasha kuma kala duwanaan kooxaha ku jira striatum ama substantia nigra (SN) (dhammaan P> 0.1). Guud ahaan PG, [11C] - (+) - Xiritaanka PHNO ee SN, halkaas oo calaamadda ugu horreyn loo aaneyn karo soo dhoweeyeyaasha D3, oo xiriir la leh darnaanta khamaarka (r = 0.57, P = 0.04) iyo kacsanaan (r = 0.65, P = 0.03) . HC, [11C] raclopride oo ku xidhan dorsal striatum waxay la xidhiidhaa si kadis ah saamaynta gambling (r = -0.70, P = 0.03) iyo is-xakameyn (r = -0.70, P = 0.03).
XUSUUS:
Maqnaanshaha maaddada isticmaalka maandooriyaha, waxaa muuqata inaanay isbeddelaynin heerarka D2 / D3 ee ka dhexeeya maaddooyinka caafimaadka leh iyo kuwa qamaarayaasha ah, iyagoo soo jeedinaya in helitaanka helitaanka hooseeya ay tahay mid aan lagama maarmaan u ah mukhaadaraadka. Si kastaba ha ahaatee, xiriirka ka dhexeeya [11C] - (+) - PHNO oo ku xiran iyo khibradda darran / niyadjabinta waxay soo jeedinaysaa kaqeybqaadashada D3 soo celinta dabeecadaha dabacsan /.
© 2012 Qorayaasha, Ciyaalka Adduunka © 2012 ee Daraasadda Ku Xadeysanaanta.
;