Dabeecadda. 1998 May 21;393(6682):266-8.
Koepp MJ, Gunn RN, Lawrence AD, Cunningham VJ, Dager A, Jones T, Brooks DJ, Bench CJ, Grasby PM.
source
Qeybta MRC Cyclotron, Isbitaalka Hammersmith, London, UK.
aan la taaban karin
Daaweynta 'neuropransmission' ee loo yaqaan 'Dopaminergic neurotransmission' ayaa laga yaabaa inay ku lug yeelato barashada, xoojinta dabeecada, feejignaanta, iyo is dhexgalka dareemayaasha. Xayiraadda radioligand 11C-ku-dheelman ee loo yaqaan 'raclopride' ee loo yaqaan 'dopamine D2 receptors' waxay u nugul tahay heerarka dopamine-ka endogenous, kaas oo lagu sii deyn karo loolanka dawooyinka. Halkaan waxaan u isticmaalnaa 11C-ku-sumadaysan oo loo yaqaan 'raclopride iyo positron emission tomography scan' si aan u bixinno caddeyn muujineysa in dopamine-ka endogenous lagu sii daayay bannaanka aadanaha inta lagu gudajiro howsha hagitaan ee hagida, taas oo ah ciyaar fiidiyaha ah. Ku xirista cunsuriyada loo yaqaan 'raclopride' ee loo yaqaan 'dopamine receptors' ee dusha sare ayaa si weyn hoos loogu dhigay intii lagu jiray ciyaarta fiidiyowga marka la barbar dhigo heerarka aasaasiga ah ee xiritaanka, oo la jaan qaada sii deynta iyo ku xiritaanka dopamine-ka qaatayaasha. Hoos u dhigista ku xirida isugeynta 'raclopride' ee marxaladda loo yaqaan 'trolopumide' ee marxaladda loo yaqaan 'trolopumide' waxay ahayd mid si wanaagsan ula xiriirtay heerka waxqabadka intii hawsha lagu jiray waxaana ugu weynaa marinka marinka. Natiijooyinkaani waxay muujinayaan, aqoonteena markii ugu horeysay, xaaladaha dabeecadaha kaas oo dopamine lagu sii daayo bini-aadamka, oo ay muujinayaan awoodda isugeynta sunta ah ee loo yaqaan 'positron emmo tomography' si loo ogaado qulqulka dareemayaasha faylalka ee vivo inta lagu gudajiro dhaqdhaqaaqa dabeecadda..
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