DIIWAANKA: Daraasad ku saabsan maadooyinka cilmiga beenta (galmada / qabatinka galmada) waxay soo sheegaysaa isbeddelada epigenetic ee u muuqda kuwa ku dhaca khamriga. Isbedelka epigenetic wuxuu ku dhacay hidda-wadayaasha la xiriira nidaamka oxygentocin (oo muhiim u ah jacaylka, isku-xirnaanta, qabatinka, walbahaarka, iwm). Waxyaabaha soo ifbaxaya:
- Calaamadaha jimicsiga jinsiga / ladagaalanka jinsiga ee nidaamka oksijiinta maskaxda waxay umuuqataa kuwa khamriga cabba
- Natiijooyinka daraasadda ayaa la jaan qaadaya Kuhn & Gallinat, 2014 (daraasad fMRI caanka ah oo ku saabsan isticmaaleyaasha filimmada)
- Natiijooyinka waxay cadeyn karaan nidaam walaac walaac leh (oo ah isbadal muhiim u ah maandooriyaha)
- Wax ka beddelka hidde-sideyaasha hiddo-wadayaasha waxay saameyn ku yeelan karaan isku-xirnaanta, walbahaarka, shaqada galmada, iwm.
Wixii dheeraad ah, akhri maqaalkan farsamo ahaan: Saynisyahannadu waxay aqoonsadeen hoormoonka laga yaabo inuu la xiriiro xanuunka galmada ee hypersexual
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Adrian E. Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, John N. Flanagan, Regina Krattinger, Marcus Bandstein, Jessica Mwinyi, Gerd A. Kullak-Ublick, Katarina Görts Öberg, Stefan Arver, Helgi B. Schiöth & Jussi Jokinen (2019) )
Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
aan la taaban karin
Xanuunka galmada ee qasabka ah (HD) waxaa loo soo jeediyay in lagu ogaado DSM-5, kala-soocidda 'Xanuunka Dhaqanka Galmada ee Khasabka ah' hadda waxaa loo soo bandhigay inay tahay khalkhal xakameyn ah oo ku jira ICD-11. HD wuxuu ku daraa dhowr farsamooyin oo ku saabsan cudurka; oo ay ku jiraan kacsi la'aan, qasab, khalkhalka rabitaanka galmada iyo qabatinka galmada. Ma jirin daraasad hore oo lagu baaray HD falanqaynta methylation-ka oo ku xaddidan microRNA (miRNA) goobaha CpG-ga ee la xiriira. Qaabka methylation-ka ee genome-ka ballaaran waxaa lagu cabiray dhiig dhan 60 maado oo leh HD iyo 33 mutadawiciin caafimaad qaba oo isticmaalaya Illumina EPIC BeadChip. 8,852 goobood oo CpG-ga la xiriira miRNA ayaa lagu baaray falanqaynno badan oo dib-u-celin toosan ah oo ku saabsan qiimaha M-methylation-ka ilaa isbeddel laba-geesood ah oo madax-bannaan oo xaaladda cudurka ah (HD ama mutadawiciin caafimaad qaba), oo loo habeeyey isku-dhafka si fiican loo go'aamiyay. Heerarka muujinta miRNAs-ka musharraxa ayaa lagu baaray isla shakhsiyaadka si loo falanqeeyo muujinta kala duwan. Meelaha methylation-ka musharraxa ayaa si dheeraad ah loo bartay si loogu xiriiriyo ku tiirsanaanta khamriga ee koox madax-bannaan oo ka kooban 107 maado. Laba goobood oo CpG ah ayaa xuduud ahaan muhiim u ahaa HD - cg18222192 (MIR708)( p < 10E-05, p FDR = 5.81E-02) iyo cg01299774 (MIR4456)(p < 10E-06, p FDR = 5.81E-02). MIR4456 si weyn ayuu uga hooseeyay HD marka loo eego falanqaynta univariate (p < 0.0001) iyo multivariate (p < 0.05). Heerarka methylation-ka Cg01299774 waxay si liddi ku ah ula xiriireen heerarka muujinta MIR4456 (p < 0.01) waxaana sidoo kale si kala duwan loogu kala saaray ku tiirsanaanta khamriga (p = 0.026). Falanqaynta saadaasha bartilmaameedka hidde-sideyaasha iyo marinnada ayaa shaaca ka qaaday in MIR4456 uu si gaar ah u bartilmaameedsado hidde-sideyaasha si gaar ah loogu muujiyo maskaxda oo ku lug leh hababka molecular-ka neerfaha ee waaweyn ee loo maleynayo inay khuseeyaan HD, tusaale ahaan, marinka calaamadaynta oxytocin. Marka la soo koobo, daraasaddeennu waxay tilmaamaysaa ka qayb qaadashada suurtagalka ah ee MIR4456 ee ku saabsan cudurka HD iyadoo si toos ah u saameynaysa calaamadaynta oxytocin.
KOOXDA QAYB QAADAN
Falanqaynta ururrada methylation-ka ee DNA-da ee dhiigga durdurinta, waxaan ku aqoonsannaa goobo CpG-ga oo kaladuwan oo la xiriira MIR708 iyo MIR4456 oo si weyn ugu kala duwan bukaannada HD. Intaa waxaa sii dheer, waxaan soo bandhigeynaa in hsamiR- 4456 laxiriira methylation locus cg01299774 ay si gaar ah uga duwan tahay ku tiirsanaanta ku tiirsanaanta aalkolada, adoo soo jeedinaya inay ugu horeyn la xiriirto walxaha qabatinka lagu arkay HD.
Aqoonteenna, ma jiro warqad hore oo sharraxday ahmiyada MIR4456 ee macnaha guud ee cilmu-nafsiga. Waxaan aqoonsannahay in miRNA-gaan uu yahay mid si ku-meel-gaar ah loo ilaaliyo marka loo eego isku-dhafka aasaasiga ah ee aasaasiga ah iyo saadaalinta qaababka timaha sare ee bilowga biloowga. Intaa waxaa sii dheer, waxaan bixinaa caddeyn muujineysa bartilmaameedyada mRNA ee MIR4456 in si gaar ah loogu muujiyo amygdala iyo hippocampus, laba qaybood oo maskaxda ah oo uu soo jeediyay Kühn et al. in lagu soo bandhigo cudurka loo yaqaan 'pathophysiology of HD [5].
Ku lug lahaanshaha dariiqa loo yaqaan 'oxygentocin way' ee lagu cadeeyay daraasaddan ayaa u muuqda mid si weyn loogu lug leeyahay astaamo qeexaynaya HD sida ay soo jeedisay Kafka et al. [1], sida rabitaanka galmada, isku-duubnaanta, galmada iyo (galmada) qabatinka. Ugu horreyntii waxaa soo saarey xudunta xudunta ah ee hypothalamus oo ay sii deysay barta dambe, oxytocin wuxuu ka ciyaaraa door muhiim ah isku xirnaanta bulshada iyo galmada taranka labka iyo dheddigga [59]. Murphy et al. wuxuu sharxay heerar sare inta lagu gudajiray kacsanaanta galmada [60]. Burri et al. Waxaa la ogaadey in intarnetka loo yaqaan 'oxygen intranasal' ee loo yaqaan 'intranasal oxytocin' ee ragga ka dhashay ay keentay koror ku yimid heerarka galmada loo yaqaan 'epinephrine plasma plasma' inta lagu gudajiro howlaha galmada iyo aragtida wax laga badelo ee kacsanaanta ah ee ah [61]. Intaa waxaa sii dheer, oxytocin ayaa loo soo jeediyay in laga hor tago waxqabadka qanjidhada hypothalamic-pituitary-adrenal (HPA) inta lagu jiro walaaca. Jurek et al. Waxaa la arkay in hababka loo yaqaan 'oxygentocin receptormediated intracellular qaab' intracellular intracellular ay dib u dhigeyso gudbinta isudhigga corticotropin-sii deynta factor (Crf) ee xudunta aasaaska, hiddo-wadaha oo si xoogan ula xiriiraya jawaabta walaaca [62].
Wax ka beddelka dariiqa tilmaamaha ee loo yaqaan 'oxygentocin roadway' ayaa sharxi kara natiijooyinka ka soo baxa Chatzittofis et al., Kaasoo indha indheeyay heerka 'HPA axis dysregulation' ee ragga qaba jahwareerka '3]. Intaa waxaa sii dheer, daraasaduhu waxay muujinayaan in oxytocin laga yaabo inuu ku lug yeesho cudurka loo yaqaan 'pathophysiology of obsessive-khasabka' (XXXX]]. Is dhexgalka oxytocin ee leh nidaamka loo yaqaan 'dopamine system', loo yaqaan 'HPA-axis' iyo habka difaaca jirka ayaa horseeday dib u soo kicinta in kala duwanaanshaha shaqsiyadeed ee heerarka oxytocin ay saameyn ku yeeshaan u nuglaanta nugul [63]. In kasta oo loo yaqaan "oxygentocin" uu hore ula xidhiidhnay nidaaminta dhaqanka bulshada iyo rabshadaha, Johansson et al. waxaa sii dheer muujinta kala duwanaanshaha hidda-socodka ee hiddo-wadeyaasha loo yaqaan 'Otototo receptor gene' (OXTR) waxay saameyn ku yeelatay rabitaanka ka-jawaabidda xaaladaha leh heerar sare oo xanaaq ah iyadoo la raacayo saameynta aalkolada [64]. Ugu dambeyntii, Brüne et al. soo gabagabeeyey in kala duwanaanshaha hidda-socodka ee OXTR ay gacan ka geysan karto sharraxidda cilmiga cudurka 'pathophysiology of disorderline depression' [65], cilmiga dabeecada ee lagu garto dysregulation daran [66].
MIR4456may waxay leeyihiin nidaam dheeraad ah oo nidaaminta ah ee HD oo aan lagu shaacin daraasadda hadda jirta. Iyadoo la tixraacayo natiijooyinkayaga, daraasadihii hore waxay soo sheegeen ururo ku saabsan habdhaqanka galmada labka iyo hiddo-wadayaasha ku lug leh nidaamka glutamatergic ee shakhsiyaadka niyad jabsan [67]. Intaa waxaa sii dheer, doorka suurtagalka ah ee 3ʹ-5ʹ-cyclic adenosine mono phosphate (cAMP) ee jiidashada galmada waxaa lagu muujiyay jiirka dumarka, adoo beddelaya phosphoprotein-32 oo horseed u ah beddelaadda kuwa qaata soo-dhoweynta [68]. Waxa xiisaha lihi, CAMP waxay sidoo kale nidaamisaa moleekuleyaasha la xidhiidha tilmaanta axon [69], sida hiddo-wadaha 'B3gnt1', kaas oo lala xidhiidho habdhaqanka galmada oo liita ee jiirka ragga.
QODOBKA KOOWAAD EE KU SAABSAN ARDAYDA:
Saynisyahannadu waxay aqoonsadaan hoormoon suurogal ah inuu xidhiidh la leeyahay cudurka hyperexual
Daraasad cusub oo lagu sameeyay ragga iyo dumarka qaba xanuunka galmada xad dhaafka ah ayaa shaaca ka qaaday doorka suurtagalka ah ee hoormoonka oxytocin, sida laga soo xigtay natiijooyinka lagu daabacay joornaalka Epigenetics . Natiijadan waxay u furi kartaa albaabka lagu daaweynayo cudurka iyadoo la abuurayo hab lagu cabudhinayo dhaqdhaqaaqiisa.
Cudurka maskaxda, ama galmada kacsan, waxaa loo aqoonsan yahay cilaaq galmo dabeecadeed oo khasab ah, oo ay ku xusantahay inuu yahay khalkhalka xakamaynta maskaxda ee Ururka Caafimaadka Adduunka. Waxaa lagu gartaa astaamaha murugada leh ee galmada, ku-khasab in la sameeyo ficillo galmo, luminta kontaroolada, ama caadooyinka galmada ee wata dhibaatooyinka ama khataraha imaan kara. In kasta oo qiyaasaha baahidu ay kala duwan yihiin, haddana suugaanta ayaa muujisa in cilad-beelku uu saameeyo 3-6% tirada dadka.
Muranka ayaa hareereeyay ogaanshaha sababta oo ah waxay had iyo goor dhacdaa iyada oo ay weheliso arrimo kale oo caafimaadka maskaxda ah, iyada oo soo jeedinaysa inay noqon karto kordhin ama muujinta cilad maskaxeed oo jirta. Wax yar ayaa laga ogyahay waxa ku saabsan neerfayaasha 'neurobiology'.
"Waxaan u dhaqaaqnay inaan baarno hababka xakameynta epigenetic ee ka dambeeya cilladda isku-darka 'hypersexual disorder' si aan u go'aansanno inay leedahay calaamado muujinaya inay ka duwanaan karto arrimaha kale ee caafimaadka," ayuu yiri qoraaga hormoodka ah Adrian Boström oo ka tirsan Waaxda Neuroscience ee Jaamacadda Uppsala, Sweden wax ka baro cilmi-baarayaasha ka socda Kooxda Daawada Andrology / Galmada (ANOVA) ee Karolinska Institutet, Stockholm, Sweden.
"Aqoonteenna, daraasaddeennu waa tan ugu horreysa ee lagu qeexo farsamooyinka epigenetic-ka ee dysregulated ee labadaba methylation DNA iyo dhaqdhaqaaqa microRNA iyo ku lug lahaanshaha oxytocin ee maskaxda ee bukaanada raadinaya daaweynta jinsiga."
Saynisyahanada ayaa cabiray qaabdhismeedka methylation DNA-ga ee dhiiga bukaanka 60 ee qaba cilad-beelka waxayna isbarbar dhig ku sameeyeen muunado laga soo qaatay mutadawiciin caafimaad qaba 33.
Waxay baarayeen gobollada 8,852 ee methylation DNA ee la xiriira microRNAs u dhawaa si loo aqoonsado wixii kala duwanaansho u dhexeeya muunadaha. Methylation DNA waxay saameyn ku yeelan kartaa muujinta hiddaha iyo shaqada hidda - socodka, sida caadiga ah u dhaqmida si loo yareeyo wax qabadkooda. Meesha laga helay isbeddelada ku dhaca methylation DNA, cilmi baarayaashu waxay baareen heerarka hidda-wadaha ee microRNA-da la xiriirta. MicroRNA-yada ayaa si gaar ah xiise u leh maxaa yeelay waxay ka gudbi karaan xannibaadda-maskaxda-maskaxda waxayna wax ka beddeli kartaa ama baabi'in kartaa muujinta illaa dhowr boqol oo hiddo-wadayaal kala duwan oo maskaxda iyo unugyada kale ah.
Waxay sidoo kale isbarbar dhig ku sameeyeen natiijooyinkooda muunado laga soo qaatay maaddooyinka 107, 24 oo iyagu ay ku tiirsan yihiin khamri, si ay u sahamiyaan urur leh dabeecad qabatin.
Natiijooyinka ayaa loo aqoonsaday laba gobol oo DNA ah oo wax laga beddelay bukaannada cilladda ka dhasha. Shaqada caadiga ah ee methylation-ka DNA-da ayaa la carqaladeeyey oo microRNA laxiriirta, ku lug leh aamusinta hidda-wadaha, ayaa la ogaaday inaanu sifiican u muuqan. Falanqaynta ayaa shaaca ka qaaday in microRNA-ga loo aqoonsaday, microRNA-4456, uu bar-tilmaameedsado hiddo-wadayaasha sida caadiga ah lagu muujiyo heerar sare oo maskaxda ah oo ku lug leh qaanuunka hormoonnada ee loo yaqaan 'oxygentocin'. Maaddaama aamusnaanta hiddo-wadaha hoos loo dhigay, oxytocin waxaa laga fili karaa inuu gaaro heerar sare, in kasta oo daraasadda hadda jirta aysan xaqiijin tan.
Waxaa lagu arkay vole gaar ah iyo noocyada asaasiga ah 'neuropeptide oxygentocin' waxay door muhiim ah ka ciyaaraysaa xeerarka dhaqanka lammaanaha. Daraasadihii hore waxay muujiyeen in oxytocin uu xiriir la leeyahay sharciyeynta bulshada iyo lammaanaha, dhalmada galmada iyo dhaqanka gardarada ah ee ragga iyo dumarka labadaba. Isbarbardhigga maaddooyinka ku xiran aalkolada ayaa muujisay isla gobolka DNA inuu si weyn u liito, iyadoo soo jeedineysa inay ugu horreyn la xiriirin karto waxyaabaha ka dhasha walaaca, sida galmada, rabitaanka galmada oo kacsan, isku-tagga iyo is-qancinta.
"Cilmi-baaris dheeri ah ayaa loo baahan doonaa si loo baaro doorka microRNA-4456 iyo oxytocin ee khalkhalka 'hypersexual disorder', laakiin natiijooyinkayagu waxay soo jeedinayaan inay mudan tahay in la baaro faa'iidooyinka daroogada iyo cilmu-nafsiga si loo yareeyo waxqabadka oksijiin," ayuu yiri Professor Jussi Jokinen oo ka socda Umeå Jaamacadda, Sweden.
Qorayaashu waxay xusayaan in xaddididda daraasadda ay tahay in farqiga macnaha ee methylation ee u dhexeeya bukaannada 'hyperexual disorder' iyo mutadawiciin caafimaad qaba ay ahayd kaliya qiyaastii 2.6%, sidaa darteed saameynta isbeddelada jir ahaana waxaa loo yeeri karaa su'aal. Si kastaba ha noqotee, jir soo koraya oo ah soo jeedinno caddeyn ah oo ah in isbedelada methylation ee khiyaanada leh ay yeelan karaan cawaaqib ballaaran oo loogu talagalay xaaladaha murugsan sida murugada ama shisoofrani.
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Daraasadda waxaa lagu maalgeliyey heshiis gobol oo u dhexeeyey jaamacadda Ume Council iyo maamulka gobolka Västerbotten (ALF) iyo deeqo ay bixiyeen maamulka gobolka Stockholm iyo sidoo kale hay'adda cilmi-baarista ee Åhlens, Novo Nordisk Foundation, iyo Hay'adda Cilmi-baarista Maskaxda ee Iswidhishka. Aasaaska.
QODOBKA LABAAD EE KU SAABSAN ARDAYDA:
Isbeddelada Epigenetic waxay ku xirnaayeen jahwareerka hyperexual dishibiliinka iyo dabeecadaha qabatimmada
MedicalResearch.com Wareysiga: Adrian E. Boström MD, anigoo ku hadlaya magaca qorayaasha
Qeybta Neuroscience, Jaamacadda Uppsala, Sweden
MedicalResearch.com: Waa maxay asalka daraasaddan?
Jawaab: In kasta oo qiyaasaha baahsanaantu ay kala duwan yihiin, haddana suugaantu waxay tilmaamaysaa in xanuunka galmada badan (HD) uu saameeyo 3-6% dadweynaha. Si kastaba ha ahaatee, muran ayaa ku xeeran cudurka, wax yar ayaana laga ogyahay cilmiga neerfaha ee ka dambeeya.
Cilad-xumada 'Hypersexual disorder' horey looma baarin iyada oo la tixraacayo epigenomic iyo transcriptomics ee habka daraasad la'aanta ah ee bilaashka ah wax yarna waa laga ogyahay neerobiology ee ka dambeeya cilladan. Waxaan baarnay haddii ay jiraan wax isbeddello epigenetic ah oo saameeya dhaqdhaqaaqa hiddo-wadaha iyo muujinta bukaannada 'hypersexual disorder' (HD) bukaannada oo aan aqoonsannay microRNA aan caadi ahayn oo la rumeysan yahay inay saameyn ku yeelanayso habka ficil-celinta hormoonka oxytocin ee maskaxda.
Oxytocin waxaa loo yaqaanaa inay leedahay saameyn dhaqameed oo ballaaran. Sida ugu fiican ee aqoonteenna ah, daraasad hore ma bixin caddayn ku saabsan xiriirka ka dhexeeya methylation DNA, waxqabadka microRNA iyo oxytocin ee xanuunka 'hypersexual disorder'. Natiijooyinkayagu waxay mudan yihiin cilmi-baaris dheeri ah oo ku saabsan doorka MIR4456 iyo gaar ahaan Oxytocin ee khalkhalka 'hypersexual disorder'. Daraasado dheeraad ah ayaa loo baahan yahay si loo xaqiijiyo doorka Oxytocin ee HD iyo in la baaro in daaweynta daweynta daroogada ee oxytocin antagonist ay saameyn ku yeelan karto bukaannada qaba xanuunka 'hypersexual disorder'.
MedicalResearch.com: Waa maxay natiijooyinka ugu waaweyn?
Jawaab: – Daraasaddan waxaan ku baarnay in ka badan 8000 oo kala duwan oo methylation DNA ah oo isku xigxigay si aan mala-awaal lahayn oo sidaas darteed aan eex lahayn. Sidaa darteed, waxaan xiiso iyo la yaabnay inaan aqoonsanno hidde-sideyaal microRNA ah oo si xooggan u nidaamsan oo bartilmaameedsanaya oo inta badan lagu muujiyo maskaxda kuwaas oo ku lug leh hababka waaweyn ee molecular-ka neerfaha ee loo maleynayo inay khuseeyaan khalkhalka galmada sare, tusaale ahaan waddada calaamadaynta oxytocin. MicroRNA- gan sidoo kale wuxuu u muuqdaa mid horumarsan oo lagu ilaaliyo dhammaan noocyada hore, taas oo sidoo kale ah natiijo xiiso leh oo lama filaan ah.
MedicalResearch.com: Maxay aqristeyaashu uga qaadan karaan warbixintaada?
Jawaab: Xanuunka galmada badan wuxuu ka kooban yahay habab kala duwan oo cudur-sidaha ah oo ay ku jiraan kacsi la'aan, qasab, khalkhal ku yimaada rabitaanka galmada iyo balwadda galmada. Tan waxaa loo fasiri karaa in xanuunka galmada badan uu ka kooban yahay walxo qabatimo leh, laakiin looma arki karo balwad gaar ah. Natiijooyinkayaga, marka la eego isku-dhafka ku-tiirsanaanta khamriga, waxay soo jeedinayaan in MIR4456 iyo marin-haweedka calaamadaynta oxytocin ay inta badan ku lug yeelan karaan qaybta qabatinka ee xanuunka galmada badan. Daraasado dheeraad ah ayaa loo baahan yahay si loo xaqiijiyo tan si buuxda.
MedicalResearch.com: Maxaad ku talinaysaa cilmi baarista mustaqbalka shaqadan ka dhalatay?
Jawaab: Natiijooyinkayagu waxay dhiirigelinayaan cilmi-baaris dheeraad ah oo ku saabsan waxtarka, tusaale ahaan, oxytocin-ka nidaamiya daaweynta daroogada ee khalkhalka galmada ee hypersexual kaas oo gacan ka geysan kara ikhtiyaarrada daaweynta cusub si loo hagaajiyo natiijada caafimaad ee kuwa ay saameeyeen. Intaa waxaa dheer, waxaan aqoonsaneynaa microRNA gaar ah (miRNA) kaas oo mustaqbalka miRNA-ga maamula daawooyinka lagu tijaabin karo khalkhalka galmada ee hypersexual.
MedicalResearch.com: Ma jiraan wax kale oo aad jeclaan lahayd inaad ku darto?
Jawaab: DNA-dayadu waa hidde-sideyaasha hidda-wadaha kuwaas oo u turjuma taxane kala duwan oo amino acids ah oo loo yaqaan borotiinno. Borotiinnadu, dhanka kale, waxay ka kooban yihiin curiye muhiim ah oo ka mid ah dhammaan noolaha. DNA-dayadu waa la dhaxlaa mana isbeddesho waqti ka dib. Si kastaba ha ahaatee, daraasaddani waxay la xiriirtay epigenetics, kuwaas oo ah isbeddello saameeya dhaqdhaqaaqa hidda-wadaha iyo muujinta. Hawlahan epigenetic-ga ayaa isbeddela waqti ka dib waxaana lagu burburin karaa cudurro gaar ah. Waxaa jira habab epigenetic oo kala duwan.
Daraasaddan, waxaan ku baranay methylation DNA (nidaam loo yaqaan inuu saameyn ku yeesho muujinta hidda-wadaha, taas oo ah, tirada hiddo-wadaha loo turjumay borotiinka) iyo waxqabadka microRNA (qaybaha hiddo-wadaha ee aan cod-qorista ahayn oo saameyn ku yeelan kara tarjumaadda dhowr boqol hiddo-wadaha kala duwan).
Isbarbardhiga bukaanada qaba xanuunka 'hypersexual disorder' iyo mutadawiciinta caafimaadka qaba, waxaan ogaanay isku xigxiga methylation DNA si aad looga badalo xanuunka 'hypersexual disorder'. Si loo hubiyo muhiimada raadintaan, isla isku xigxiga DNA-da ayaa si dheeri ah loo muujiyey in lagu jahwareeray maadooyinka ku tiirsanaanta khamriga, taasoo soo jeedinaysa inay ugu horeyntii la xiriiri karto qeybta balwadda leh ee khalkhalka galmada. Isku-darka methylation DNA ee la aqoonsaday wuxuu la xiriiray microRNA loo yaqaan (microRNA 4456; MIR4456), iyo falanqeyn dheeri ah ayaa muujisay in isku xigxiga methylation DNA-kan uu saameyn ku yeelanayo tirada MIR4456 ee la soo saaray. Intaa waxaa sii dheer, isla kooxdii daraasadda, waxaan muujineynaa in MIR4456 ay ku jirto tiro aad u hooseysa oo ku saabsan cilladda 'hypersexual disorder' marka la barbardhigo mutadawiciinta caafimaadka qaba, iyagoo si xoog leh u soo jeedinaya in qaababka methylation DNA ee wax laga beddelay ee ku saabsan saameynta khalkhalka 'hypersexual disorder' iyo ay gacan ka geysato sharraxaadda u kuur galka MIR4456. Maaddaama microRNA: s aragti ahaan ay awoodaan inay bartilmaameedsadaan dhowr boqol oo hiddo-wadayaal kala duwan, waxaan adeegsanay algorithms-ka kumbuyuutarka si aan u muujino in MIR4456 ay bartilmaameedsato hiddo-wadaha si doorbid ahaan loogu muujiyo maskaxda oo ku lug leh farsamooyinka waaweyn ee neerfayaasha neerfaha ee loo maleeyo inay ku habboon yihiin HD, tusaale ahaan, oxytocin wadada calaamadeynta. Natiijooyinkayagu waxay mudan yihiin cilmi-baaris dheeri ah oo ku saabsan doorka MIR4456 iyo gaar ahaan Oxytocin ee khalkhalka 'hypersexual disorder'. Daraasado dheeri ah ayaa loo baahan yahay si loo xaqiijiyo doorka Oxytocin ee HD iyo in la baaro in daaweynta daweynta oksijiinta ee daweynta daroogada ay saameyn ku yeelan karto bukaanada qaba xanuunka 'hypersexual disorder'.
Hase yeeshee xogta aan la daabicin ee loogu talagalay daraasad dabagal ah oo gooni ah ayaa muujineysa koror aad u weyn oo heerarka Oxytocin ah ee bukaannada qaba cilladda 'hypersexual disorder' marka la barbardhigo kontaroolada, iyo hoos u dhac weyn oo ku yimaada heerarka oxytocin ka dib daaweynta Cognitive Behavior Therapy, oo si xoog leh u tilmaamaya doorka sababaha Oxytocin khalkhal galmo galmo iyo sameynta sheegashooyinka lagu soo bandhigay daraasaddan oo aad u xoog badan. Natiijooyinkan horudhaca ah waxaa loo soo bandhigay inay yihiin boodhadh dambe oo ka hadlaya shirkii cilmi nafsiga ee bulshada bishii Maajo 2019 waxaana sidoo kale loo soo gudbiyay warqad ahaan ACNP bishii Diseembar 2019.
Sharax:
Adrian E. Boström et al, Hoos u dhaca ku yimaada hoos u dhaca microRNA-4456 ee khalkhalka galmada ee hypersexual oo leh saameyn ku saabsan calaamadaynta oxytocin: Falanqaynta methylation-ka DNA ee hiddo-wadaha miRNA, Epigenetics (2019). DOI: 10.1080/15592294.2019.1656157