Neuropharmacology. 2016 Dec; 111: 223-230. Doi: 10.1016 / j.neuropharm.2016.09.006.
Cameron CM1, Wightman RM2, Carelli RM3.
inahaneloang
Bokhoba ba koae ke boloetse bo sa foleng bo khutlang bo thata ho bo phekola ka karolo e 'ngoe hobane ba lemaletseng ba khutlela morao le kamora nako e telele ea ho ithiba. Ka lebaka la bohlokoa ba sistimi ea mesolimbic dopamine (DA) ea ho lemalla lithethefatsi, re ile ra batla ho khetholla ts'ebeliso ea koae ea cocaine e bakileng liphetoho pontsong e potlakileng ea DA ho li-nucleus accumbens (NAc). Mona, likhoto li ile tsa koetlisetsoa ho itšebelletsa cocaine ka matsatsi a 14 a latellanang, ebe li aroloa ka lihlopha tse peli. Likhoto tsa letsatsi la 1 (D1; n = 7) li bile le 24 h ea ho ithiba; Likhoto tsa 30 tsa letsatsi (D30; n = 7) li qetile khoeli e le 'ngoe li ithiba. Kamora ho ithiba, likhoto tsohle li ile tsa fela ka mokhoa o le mong. Hanghang kamora moo, likhoto li ile tsa sebelisoa ka mokhoa o thethefatsang le ho potlakisa cyclic voltammetry (FSCV) ho sebelisoa ho lekanya ho lokolloa ha DA le ho nka matla kahare ea NAc pele le ho latela ente e le 'ngoe ea cocaine. Re bontša hore khoeli e le 'ngoe ea ho ithibela koae e baka tšisinyeho ea tlhonamo ea DA e ileng ea tsosa motlakase mokokotlong oa NAc kamora ho entetsoa ka matla cocaine. Sena se ke ke sa amana le liphetoho lipakeng tsa litekanyetso tsa DA tsa tšebetso, tse sa fetoloeng ka mor'a ho ila, empa li ka supa liphetoho tse lokollotsoeng. Liphetho tsena li boetse li tšehetsa lingoliloeng tse ngata tse bonts'ang hore ho se thibele koae ho khatholla neuroplasticity libakeng tsa boko tse kenyelletsang moputsong oa lithethefatsi le ho oela hape.. Liphumano tse teng hona joale li bonts'a phapang e kholo lipakeng tsa neuroadaptations tse bakoang ke ho itšireletsa khafetsa ho lets'oao la DA le tse hlahisoang ke ho pepesetsoa hoa lithethefatsi ka boyona.
LINKOTSO:
Tlatsetso; Cocaine; Dopamine; Fast-scan cyclic voltammetry; Rat; Boitlhotlhollo
PMID: 27616012
PMCID: PMC5066595
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