LITABA: Le ha pampiri ena e le buka e fokolang feela, e na le litlhaloso tse 'maloa tsa bohlokoa ho saense e hlahang. Mohlala, e re bobeli Prause et al., 2015 le Kuhn le Gallinat, 2014 bolela tlaleho e tšoanang: ho sebelisa litšoantšo tse ngata tse hlephisang boitšoaro ho amana le litloaelo tse ngata tsa litšoantšo tsa bootsoa. Liphuputso tsena ka bobeli li tlalehile tlaase ho sebetsa ka bokooa ho arabela ka ho pepesehela habonolo litšoantšo tsa bootsoa ba vanilla. Lekhetlong le latelang "Ntho e ka tlaase ho nako e ntle" e bolela ho fumanoa ha EEG Prause et al.:
"Ka papiso, lithuto ho batho ba phetseng hantle li fana ka maikutlo a bohlokoa bakeng sa ho ntlafatsa tloaelo ea ho sebelisa litšoantšo tsa bootsoa ka tsela e feteletseng. Ho banna ba phetseng hantle, nako e eketsehileng e sebelisitsoeng ho shebella litšoantšo tse manyala tse hlephisang boitšoaro tse amanang le setšoantšo se ka tlaase sa putaminal ho litšoantšo tsa bootsoa (Kühn le Gallinat, 2014). Mesebetsi e tlaase ea nakoana e ntle litšoantšo tse manyala tse hlephisang boitšoaro li ile tsa bonoa lihloohong tse nang le bothata ba ho sebelisa litšoantšo tsa bootsoa. ”
Hobaneng see e le sa bohlokoa? Sengoli se etelletseng pele Nicole Prause o boletse hore thuto ea hae e le 'ngoe ea EEG e hlahisitse "lithethefatsi tsa bootsoa". Ena ke pampiri ea bobeli e hlahlojoang ke lithaka ho hana litlhaloso tsa Prause. Mona ke pampiri ea pele.
Tlhokomeliso - Lipampiri tse ling tse ngata tse hlahlojoang ke lithaka lia lumela hore Prause et al., 2015 e ts'ehetsa mohlala oa ho lemalla lit soant so tsa bootsoa: Litlhaloso tse hlahlojoang ke lithaka tsa Prause et al., 2015
Neuropsychopharmacology 41, 385-386 (January 2016) | tse pedi: 10.1038 / npp.2015.300
Shane Kraus 1, 2, Valerie Voon 3, le Marc N Potenza 2, 4
1 VISN 1 Lefu la kelello Thuto le Lipatlisiso tsa Meriana, VA Tsamaiso ea bophelo bo botle ba Connecticut, West Haven, CT, USA; Lefapha la Psychiatry la 2, Sekolo sa Meriana sa Yale University, New Haven, CT, USA;
Lefapha la Psychiatry la 3, Univesithing ea Cambridge, Cambridge, UK;
4 Lefapha la Neurobiology, Setsi sa Thuto sa Bana le CASA Columbia, Yale University Sekolo sa Bongaka, New Haven, CT, USA
E-mail: [imeile e sirelelitsoe]
Boitšoaro bo hlephileng ba ho kopanela liphate (CSB) bo khetholloa ke takatso, ho hloka tšusumetso, ho senyeha ha sechaba / ts'ebetsong, le bothata ba kelello. Ho ata ha CSB ho hakanngoa ho potoloha 3-6%, le banna ba bangata. Le hoja e sa kenngoa DSM-5, CSB e ka fumanoa ka ICD-10 e le lefu la ho laola maikutlo. Leha ho le joalo, moqoqo o teng mabapi le likarolo tsa CSB (mohlala, e le bothata ba ho qobella motho ho itšunya-tšunya, e leng tšobotsi ea bothata ba ho kopanela liphate, ho tsuba, kapa ho tsoelapele ka boitšoaro bo hlephileng ba ho kopanela liphate).
Bopaki ba pele bo bontša hore dopamine e ka kenya letsoho ho CSB. Parallinson's (PD), dopamine phekolo ea phekolo (Levo-dopa, dopamine agonists) e amahanngoa le CSB le mathata a mang a ho laola maikutlo (Weintraub et al, 2010). Palo e fokolang ea lintlha tse sebelisang naltrexone ts'ehetso ea eona ka katleho ea ho fokotsa litakatso le mekhoa e amanang le CSB (Raymond et al, 2010), e lumellanang le phetoho ea opioidergic ea mesolimbic dopamine e sebetsang ho fokotsa CSB. Hona joale, ho na le liteko tse kholo, tse nang le matla a ho etsa lipatlisiso le lithethefatsi tse lekaneng, tse hlokahalang ho ntlafatsa morero oa CSB.
Khothatso ea ts'ebetso ea ts'ebetso e amanang le thobalano ea reactivity. CSB le banna bao e seng ba CSB ba ne ba e-na le ts'ebetso e kholo ea ho kopanela liphate-cuerelated ea pele-pele, e leng ventral striatum le amygdala (Voon et al, 2014). Lihloohong tsa CSB, ho hokahanya ha mosebetsi oa marang-rang ona ho amana le takatso ea thobalano e amanang le thobalano, kahoo ho hlahella ka liphuputso tsa lithethefatsi tsa lithethefatsi (Voon et al, 2014). Banna ba CSB ba tsoela pele ho bonts'a boiketlo ba ho shebella litšoantšo tse hlephisang boitšoaro, ho ameha ka likarabo tsa pele tsa ho shebella litaba tse kang ho lemalla (Mechelmans et al, 2014). Bakeng sa bakuli ba CSB le bao e seng ba CSB PD, ho pepesehela litšoantšo tsa bootsoa ho ile ha eketsa ts'ebetso boemong ba ho ba le sekhahla, ho kopanya le ho loantša li-cortex, ho kopanya le takatso ea thobalano (Politis et al, 2013). Thuto e fokolang ea ho nahana ka litšoantšo e senya liketso tse sa tloaelehang tsa CSB le banna bao e seng ba CSB (Miner et al, 2009).
Ka lehlakoreng le leng, lithuto tsa batho ba phetseng hantle li fana ka maikutlo a karolo ea ho ntlafatsa tikoloho le ts'ebeliso e mpe ea litšoantšo tsa bootsoa. Bakeng sa banna ba phetseng hantle, nako e eketsehileng e sebelisitsoeng ho shebella litšoantšo tsa bootsoa e tsamaellana le ts'ebetso e tlase e tlohang letsohong le letšehali ho litšoantšo tsa bootsoa (Kühn le Gallinat, 2014). Mosebetsi o tlase o ileng oa hlahisa litšoantšo tse litšila tse tsosang takatso o ile oa bonoa lithutong tse nang le bothata ba tšebeliso ea litšoantšo tse litšila tse tsosang takatso. Liphuputso tsena, ha li bapisoa, ha li lumellane. Ho tloaela ho sheba litšoantšo tse amanang le video e ka ntlafatsoa ho batho ba phetseng hantle ba nang le tšebeliso e feteletseng; empa, lihlooho tsa CSB tse nang le ts'ebetso e matla haholo kapa tse nang le ts'oaetso li ka 'na tsa ntlafatsa cue reactivity.
Le hoja lipatlisiso tsa morao-rao tsa morao-rao li bontšitse hore ho na le mekhoa e meng ea phekolo ea kelello ea CSB, liphello tsena li lokela ho tšoaroa e le ho fokotseha ho fanoeng ka meeli ea mokhoa (mohlala, mekhahlelo e nyane ea lipeo, lihlopha tse fapaneng, lihlooho tsa banna feela joalo-joalo). Likhahla tsa morao tjena tsa lipatlisiso li na le mathata a hlakileng a hore na CSB e nkoa e le meriana kapa che. Lipatlisiso tse ling li hlokahala ho utloisisa hore na likarolo tsa neurobiological li amana joang le litekanyetso tse amehang joaloka liphello tsa kalafo bakeng sa CSB. Ho khetholla CSB e le 'ho lemalla boitšoaro' ho tla ba le liphello tse kholo bakeng sa boiteko ba tsamaiso, thibelo le kalafo; leha ho le joalo, nakong ena, lipatlisiso li sa le monyenyane. Ho fanoe ka ho tšoana ho teng pakeng tsa lik'homphieutha tsa CSB le lithethefatsi, mehato e atlehang bakeng sa lithethefatsi e ka 'na ea e-ba le tšepiso ea CSB, kahoo e fana ka temohisiso mabapi le lipatlisiso tsa nakong e tlang hore li batlisise sena ka ho toba.
- Kühn S, Gallinat J (2014). Mekhoa ea boko le ho sebetsa ho amanang le litšoantšo tsa bootsoa: boko ba litšoantšo tsa bootsoa. JAMA Psychiatry 71: 827-834.
- Mechelmans DJ, Irvine M, Banca P, Etela L, Mitchell S, Mole TB le al (2014). Ho ntlafatsa boiketlo ba litabeng tsa thobalano ho batho ba nang le boitšoaro bo bobe ba ho kopanela liphate le ba se nang boikemelo. PloS One 9: e105476.
- Miner MH, Raymond N, Mueller BA, Lloyd M, Lim KO (2009). Tlhahlobo ea pele ea litšobotsi tse sa tsitsang le tsa tšohanyetso tsa boitšoaro bo hlephileng ba ho kopanela liphate. Psychiatry Res 174: 146-151.
- Politis M, Loane C, Wu K, O'Sullivan SS, Woodhead Z, Kiferle L et al (2013). Tlhaloso ea li-neural ho tsejoang ka thobalano e ts'oaetsanoang ka bongata bo bong bo amanang le lefu la Parkinson. Bokooa 136: 400-411.
- Raymond NC, Grant JE, Coleman E (2010). Ho eketseha ka naltrexone ho tšoara boitšoaro bo bobe ba likamano tsa botona le botšehali: lihlooho tsa liketsahalo. Ann Clin Psychiatry 22: 55-62.
- Voon V, Mofuta oa TB, Banca P, Porter L, Morris L, Mitchell S le al (2014). Mekhoa e metle ea likamano tsa botona le botšehali ka ho kopanela liphate ho batho ba nang le mekhoa ea ho kopanela liphate le ntle le ho qobella. PloS One 9: e102419.
- Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V le al (2010). Mathata a ho laola tšusumetso ho mafu a Parkinson: ho hlahloba lihlopha tsa bakuli ba 3090. Arch Neurol 67: 589-595. Litlhahlobo tsa Neuropsychopharmacology (2016) 41, 385-386; doi: 10.1038 / npp.2015.300
;