(L) Bongoli Buildup ea Delta-FosB e baka ho lemalla

LITABA: Delta-FosB ke k'hemik'hale ea boko (transcript factor) ea bohlokoa ho theheng lithethefatsi. E haha ​​ka "litlatsetso tsa tlhaho," joalo ka ts'ebeliso e phahameng ea lijo tse mafura / tse tsoekere, le maemo a phahameng a boikoetliso ba 'mele le thobalano (mme ha ho pelaelo, bokhoba ba litšoantšo tsa bootsoa). Mehloli e meng e fana ka maikutlo a hore e ea fokotseha ho pota beke ea 6-8 ea ho ila lithethefatsi kapa boitšoaro.


Ke William McCall

http://biopsychiatry.com/cocaine/index.htm

Cocaine e ka ba e 'ngoe ea litheko tse matla ka ho fetisisa tsa ho folisa hobane e etsa hore ho be le protheine e phehelang bokong mme e tsose liphatsa tsa lefutso tse matlafatsang takatso ea lithethefatsi.

Bo-rasaense ba Sekolo sa Bongaka sa Yale ba ile ba khona ho khetholla protheine ea nako e telele, e bitsoang Delta-FosB, mme ba bonts'a hore e ile ea baka tšenyo ha e lokolloa sebakeng se itseng sa methapo ea kelello ea litoeba tsa lefutso.

Protheine (e tsejoang e le fawz-bee) ha e hlahisoe bokong ho fihlela ba lemalloang ba sebelisitse k'hok'heine makhetlo a 'maloa, kapa esita le ka lilemo tse' maloa. Empa hang ha bohahlauli bo qala, tlhoko ea sethethefatsi e ba matla le boits'oaro ba mosebelisi bo fetoha bo qobelloang le ho feta.

Eric Nestler, ea neng a etelletse pele phuputso eo, o re: "E batla e tšoana le phetoho ea limolek'hule." Hang ha e buletsoe, e lula e le teng, 'me ha e tlohe habonolo. ”

Lintho tse fumanoeng, tse tla phatlalatsoa ka Labone koranteng ea Nature, li bitsoa "tse ntle" le "tse bohlale" ke bafuputsi ba bang ba reng e fana ka bopaki ba pele ba konkreite ba hore ts'ebeliso ea lithethefatsi e baka phetoho e itseng ea nako e telele khemisteng ea boko.

Phuputso eo e bonts'a liphatsa tsa lefutso ha se sesosa sa ho lemalla ho sebelisa lithethefatsi ka nako e telele, ho boletse Alan Leshner, motsamaisi oa National Institute on Drug Abuse, e thusitseng karolo ea boithuto.

Leshner o itse: "Liphatsa tsa hau tsa lefutso ha li u felise hore u be lekhoba la lithethefatsi."

Li mpa li etsa hore u be bonolo, kapa hanyane. Ha ho mohla re kileng ra fumana liphatsa tsa lefutso tse u thibelang ho ba lekhoba la tahi kapa tse u laelang hore u tla ba lekhoba la tsona.

Nestler le basebetsi-mmoho ba ile ba kopanya lipatlisiso tsa liphatsa tsa lefutso le biochemical ho khetholla protheine ea Delta-FosB le sebaka sa boko seo se se amang, joale ba ile ba etsa lithuto tsa boitšoaro litoeba.

Hang ha boemo ba Delta-FosB bo bokellana, e qala ho laola liphatsa tsa lefutso tse laolang sebaka sa boko se bitsoang li-nucleus accumbens, sebaka se kenyelletsang boitšoaro bo makatsang le likarabo tsa thabo.

Ba nahana hore Delta-FosB e boetse e kenya liphatsa tsa lefutso tse ling tse hlahisang metsoako ea biochemical e bitsoang glutamates, e tsamaisang melaetsa liseleng tsa boko. Li-receptors tse ka har'a lisele tsa boko li ba le hloko haholo ho glutamate, haholo-holo ka har'a li-nucleus accumbens.

Ho leka khopolo ena, ba kentse liphatsa tsa lefutso tse amanang le glutamate ka har'a li-nucleus tsa litoeba tsa liteko. Litoeba tseo li bontšitse keketseho e "makatsang" ea kutlo ea cocaine, ba tlaleha.

"Ena ke tsoelo-pele e kholo kutloisisong ea rona ea bokhoba," ho boletse Francis White, molulasetulo oa litlhare tsa lisele le limolek'hule ho Finch University of Health Science e Chicago.

Bafuputsi ba bang ba ne ba le hlokolosi haholoanyane, ba hlokomela hore bokhoba ke ntho e rarahaneng ho batho hobane e amana le ho ithuta le mekhoa e mengata ea lik'hemik'hale bokong.

"Ha ho hlake ho 'na hore ho na le tsela e arohaneng ea limolek'hule e tla sebelisoa ka tšebeliso e mpe ea lithethefatsi eseng ho kena-kenana le thuto e ngoe," ho boletse Gary Aston-Jones oa Univesithi ea Pennsylvania School of Medicine.

Takatso ea koae e ka ba matla haholo, motho ea lemaletseng koae ea lemaletseng lithethefatsi ka lilemo tse ngata a ka qala ho ikutloa a le maphathaphathe ka ho bona ntho e amanang le ts'ebeliso ea lithethefatsi, joalo ka $ 100 bili kapa seterata se tloaelehileng sa Aro- Ho boletse Jones.

"O batla ho kokota mohopolo bakeng sa sethethefatsi empa ha o batle ho kokota mohopolo oa tsela e lebang hae," a rialo.

Steve Hyman, motsamaisi oa National Institute of Mental Health, o re liphuputso li boetse li bonts'a ho hahoa ha protheine ea Delta-FosB e ka ba lebaka la lithethefatsi tse ling, ho kenyeletsa amphetamine, morphine, heroin le nikotine.

"Lena ke lejoe la bohlokoa la ho hata empa ho na le tsela e telele eo u lokelang ho e nka," ho boletse Hyman.