Nako ea phetoho: Boits'oaro le mekhoa e metle ea kutloisiso ea bocha ea ho ba le tšusumetso e matla le e tsitsitseng ea tikoloho (2010)

Kelello ea Brain. 2010 Feb; 72 (1): 124-33.

mohloli o moholo

Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA. [imeile e sirelelitsoe]

inahaneloang

Nako ea bocha ke nako ea nts'etsopele e kenyelletsang liphetoho tse kholo boits'ebetsong bo amanang le bongoana le ho ba le takatso ea ho batla ho khothaletsoa ho kenyeletsa le ho ba motho e moholo. Tlhahlobo ena e bua ka liphetoho le boits'oaro bo susumetsoang ke bacha le mekhoa ea bona e amanang le neural, e shebaneng le tšebelisano e matla lipakeng tsa amygdala, ventral striatum, le cortex ea pele. Liphetoho tsa boitšoaro bo tloaelehileng lilemong tsa bocha li kanna tsa amahanngoa le karabelo e matla ho litheko le litakatso tsa maikutlo ha matla a ho kenya letsoho ka mokhoa o hlakileng taolong ea kutloisiso le maikutlong a sa ntsane a le monyane. Re totobatsa mosebetsi o matla ho batho le liphoofolo tse shebanang le tšebelisano lipakeng tsa litsamaiso tsena tsa mahlale a lilemong tsa bocha tse amanang le bana le batho ba baholo, mme re fana ka tlhahiso ea mofuta oa neurobiological e ka ikarabellang bakeng sa liphetoho tse sa amaneng le boitšoaro ba bocha. Kamora nako, re tšohla litšusumetso tse ling tse ka bakang moputso o fetelletseng le tšebetso ea maikutlo e amanang le bocha, ho kenyelletsa ho feto-fetoha ha maemo ha lihormone le karolo ea tikoloho ea sechaba.

2009 Elsevier Inc. Litokelo tsohle li sirelelitsoe.

Keywords: Bacha, boko, nts'etsopele, fMRI, maikutlo, moputso, taolo ea kelello, khokahano, lithaka, kotsi, ts'ebetso, amygdala, li-bokellase tsa nucleus, cortex ea pele

Selelekela

Tlhaloso ea bocha e le "nako ea nts'etsopele ea phetoho e fetohang" e kanna ea ba selelekela ho rona ba nahanang ka boiphihlelo ba rona nakong ena ea bophelo, kapa ba bonang bocha kajeno (Hall, 1904). Bokhachane bo ka hlalosoa e le mohato oa phetoho ea butle-butle pakeng tsa bongoana le ho ba motho e moholo, e ntseng e phahama empa e fapana ka ho fapana le liphetoho tsa 'mele tse bontšang ho kena bohlankaneng kapa bophahamong ba mmele.Ernst, Pine, le Hardin, 2006; Spear, 2000). Lilemong tsa morao tjena, bafuputsi ba tsoang lenaneong le pharaletseng la lithutong tsa mahlale ba bontšitse thahasello e kholo nakong ena ea bophelo ka lebaka la liphetoho tsa bona tse tebileng 'meleng, boits'oarong, sechabeng le methating, le lipalo tse tšosang tsa bophelo bo amanang le nako ena ea bophelo.

Ntle le lithahasello tsa mahlale nakong ena e le tšibollo ea kelello ka nako, lipatlisiso tse lekolang boits'oaro ba bongoana le liphetoho tse amanang le eona tsa neural li bohlokoa haholo ho bophelo ba bocha. Bocheng, ho ba le tekanyo e phahameng ea ho etsa boits'oaro bo kotsi bo ka lebisang liphellong tse mpe, ho kenyelletsa ho sebelisa lithethefatsi hampe, thobalano e sa sirelitsoeng, ho utloisa ba bang kotsi, likotsi le lefu. Ho latela Phuputso ea Bacha ba Kotsi ea Bacha ea 2007 (YRBS, Eaton, et al., 2008) lisosa tse 'ne tse ka sehloohong tsa lefu tse bakang 72% ea lefu la bocha - likotsi tsa makoloi, likotsi tse sa etsoang ka boomo, polao le ho ipolaea - li ka thibeloa. Lipalo-palo tse joalo li fana ka maikutlo a hore lipolao tsena li ka bakoa ke karolo e 'ngoe ke likhetho tse fosahetseng kapa liketso tse kotsi (mohlala, likotsi, likotsi) le / kapa maikutlo a phahameng (mohlala, ho ipolaea) ho hatisa bohlokoa ba ho utloisisa motheo oa tlhaho oa ho batla le ho susumetsa maikutlo. Boitšoaro ba bacha, tsepamiso ea maikutlo ea hona joale.

Sefefo le khatello ea maikutlo? Liphetoho tse amehang nakong ea bohlankana

Nako ea bocha e se e nkoa e le nako ea khatello ea maikutlo (Spear, 2000) ka lebaka la phetolo ea liphetoho tse etsahallang a le mong, ho kenyeletsa le ho holofala 'meleng, ho ikemela bakeng sa boipuso, ho eketseha ha tšebelisano' moho le lithaka le kholo ea kelello (Blakemore, 2008; Casey, Getz, & Galvan, 2008; Casey, Jones, & Hare, 2008). Le ha boipuso bo fumanehang bocha le ho ikamahanya le maemo sechabeng ho ka u hlasimolla le ho phephetsa ka tsela e nepahetseng, e kanna ea lebisa ho maikutlo a ho sithabetsoa ke phetoho, e leng se ileng sa etsa hore bafuputsi ba bang ba boneng bocha e le bo ratoang ke 'sefefo le khatello ea maikutlo' (Hall, 1904). Maikutlo a phehisano a 'sefefo le khatello ea maikutlo' a matlafatsoa ke litlaleho tsa hore ho qaleha ha maloetse a mangata a kelello ho eketseha haholo ho tloha bongoaneng ho ea bohlankaneng (Likhomphutha, Orosan, & Grant, 1993), ka kotsi ea bophelo bakeng sa ho hlaha ha bokuli ba kelello bo eketsehang ho lilemo tsa 14 (Kessler, et al., 2005). Leha puisano e felletseng ea palo ea batho ba lilemong tsa bocha e khahla sehlooho sena, e kantle ho tekolo ea tlhahlobo ea hona joale mme re fetisetsa 'mali ho lihlooho tse seng li ntse li sebetsana le litaba tsena ka botlalo.Paus, Keshavan, & Giedd, 2008; Steinberg, 2005).

Mabapi le boholo ba maikutlo a fapaneng, lihlopha tse ling tsa maemo a sithabetsang maikutlo - haholo maemo a mabe a maikutlo-li bonts'a tlhalo e atileng nakong ea bohlankanaLik'hamphani, Hinden, & Gerhardt, 1995; Petersen, et al., 1993; Rutter, et al., 1976). Haufinyane tjena, sephetho sa YRBS se bonts'itse hore selemong se ka pele, bacha ba fetang a le mong ho bacha ba bane (27.3%) ba bile le matšoao a bohlokoa a khatello ea maikutlo bonyane libeke tse peli, ho isa moo bo sitisang tšebetso ea bona ea letsatsi le letsatsi (Eaton, et al., 2008). Ho ba le tšusumetso e mpe khafetsa ho atile haholo lilemong tsa pele tsa bohlankana, haholo ho basali ho feta ba batona (Larson, Moneta, Richards, & Wilson, 2002) hape, ho ekelletsa mochesong o utloisang bohloko, e boetse e iponahatsa ka matšoenyeho (Abe & Suzuki, 1986), ho itšepa, le ho itšepaSimmons, Rosenberg, & Rosenberg, 1973; Thornburg le Jones, ka 1982). Ho ikutloa u hloname, o tepelletse maikutlo kapa o hloka tšepo o ka amahanngoa le litekanyetso tse phahameng tsa mathata a amanang le mathata, ho leka le ho qeta ho ipolaea, le tšibollo le eona e hlokometsoe lilemong tsa bocha.Pine, Cohen, & Brook, 2001; Silveri, Tzilos, Pimentel, & Yurgelun-Todd, 2004; Steinberg, 2005, Mościcki, 2001). Lipalo-palo tsena li totobatsa tlhoko ea ho utloisisa motheo oa 'mele oa liphetoho tsena tsa maikutlo ho bacha.

Kamora nako, maikutlo a mabe a bacha ha a khafe feela empa maikutlo a bona a maikutlo a boetse a tebisa maikutlo, a fetoha ebile a tlas'a maemo a feteletseng a amanang le batho ba baholo (Arnett, 1999; Buchanan, Eccles, & Becker, 1992; Eccles, et al., 1989; Simmons le Blyth, 1987). Larson le basebetsi-'moho (2002) ba etsa lipatlisiso tsa karolo e khuts'oane tse neng li nka mohlala oa bokhutšoaane ba bacha ba pele makhetlo a 'maloa ka letsatsi bakeng sa beke, mme a khutlisetsa batho bao lilemo tse ka bang tharo hamorao, kamora hore ba fetohe boroetsaneng. Liphetho li bonts'itse hore bacha ba lilemong tsa bocha, tse hlalosoang mona e le liithuti tsa bohlano ho isa ho tse robeli, ba bile le phokotso e kholo ea nako e khuts'oane molemong oa mmuso o amanang le seo batho ba ts'oanang ba bileng sehlopheng sa borobong ho isa ho sa leshome le metso e mmedi (Larson, et al., 2002). Phuputso ena le tse ling li bonts'a hore maikutlo a bongoaneng a hangata a ba boima ho feta bana le batho ba baholo, mme sena se bonahala e le 'nete haholo lilemong tsa bohlankana.

Mosebetsi o sa tsoa hlalosa o fana ka setšoantšo se lerootho, a fana ka maikutlo a hore lilemo tsa bocha li entsoe e le nako e mpe ea bophelo. Leha ho le joalo, ho bohlokoa ho hlokomela hore bacha ba bangata ha ba hlile ha ba utloe bohloko, 'me buisana ka nako ena e ka ba bonolo ka bonolo le ntle le mathata a tšoarellang (Steinberg, 2008). Re lumela hore leeme le teng ka tlhaiso-leseling e ka kenyang karohano ena - ha lithuto tse ngata li botsa bacha hore ba tlalehe ka maikutlo a bona a mabe, ke ba fokolang ba botang ka maikutlo a monate ao le ona a ka phahamisoang nakong ena (bona Ernst et al., 2005). Ka lebaka leo, pono ea hajoale mabapi le ts'ebetso ea bongoana ha e ea ikemisetsa mabapi le ho ba le "sefefo le khatello ea maikutlo", empa e pheha khang ea hore ho ba mocha e ka ba sesosa sa ho ba le maikutlo a matla a maikutlo (Arnett, 1999).

Boitšoaro bo susumetsoang ke bongoa

Karolong e fetileng re netefalitse hore hangata bacha ba ba le maikutlo a mabe le a fetoha. Leha ho le joalo, nako ea bocha e boetse e tšoaetsoa ke ntlafatso e senang taolo mo boits'oarong bo nkang kotsi, e khetholloang ka ho fihlela liphihlelo tse monate ntle le tlhompho e nepahetseng litlamorao tsa bona tse ka bang tse mpe. Litsi tse 'maloa tsa data ea mafu a seoa li ts'ehetsa conceptualization ena ea bocha ba boitšoaro. Haholo-holo bacha ba etsa ho khanna ho kotsi le ho feta, ts'ebeliso e seng molaong ea lithethefatsi, liketso tsa botlokotsebe le boits'oaro bo sa bolokehang ba thobalano ho feta bana le batho ba baholo.Lekhotla la Naha la Lipatlisiso, 2007; Ts'ebeliso e Mpe ea Ts'ebeliso e Mpe ea Ts'ebeliso e Mpe ea Ts'ebeliso ea Litšebeletso tsa Bophelo ba kelello, 2007; Eaton et al., 2008). Lipalopalo tsena tsa bophelo bo botle li fana ka maikutlo a hore bacha ba beha bophelo kotsing, empa litšusumetso tsa tikoloho joalo ka taolo e fokotsoang ea batsoali le phihlello e eketsehileng ea maemo a behang kotsing li ka boela tsa hlalosa keketseho ea ho nka likotsi lipakeng tsa bongoana le boroetsana.

Mosebetsi o matlafatsang ts'ebetso ea ho beha likotsi libakeng tse laoloang o ts'ehelitse haholo maikutlo a hore bacha ba bontša ho nka likotsi ntle le tlhokahalo e fapaneng ea tikoloho. Cauffman le bo-mphato ba hae (2009) ba sebelisitse mosebetsi oa ho becha oa Iowa ho leka barupeluoa ba fapaneng ka lilemo ho tloha lilemong tsa bocha ba bocha (10 ea lilemo li) ho ea ho motho e moholo (ho fihlela ho 30 ea lilemo li). Ho sebelisa ts'ebetso ena, ho etsa liqeto tse amanang le ho qoba ho phethoa ho ile ha baloa ka thoko ka ho lekola bokhoni ba barupeluoa ba ho sebelisa tlhahlobo ho ithuta ho atamela litaele tsa likarete tse ntle tse ntle. Ba fumane hore maemo a ho amohela meputso a ka ba teng a nkile karolo e itseng, le matla a maholo a ho fana ka maikutlo a nepahetseng a hlahang lilemong tsa bocha. Ho fapana le hoo, tšebeliso ea maikutlo a fosahetseng ho qoba liphetho tse mpe tse matlafatsoang le botsofali ka tatellano, ha e bontše kholo e felletseng ho fihlela lilemong tsa bocha. Liphumano tsena li fana ka maikutlo a hore bacha ba ka ba le tšekamelo ea mokhoa o sa khetholloeng, ba raliloe ka tšekamelo ea nakoana ea thibelo, e ka hlalosang tšusumetso e seng molaong ea boits'oaro bo nkang kotsi. Liphumano tsena li tsamaellana le liphetho tsa Figner le basebetsi-'moho (2009), ea sebelisitseng mosebetsi oa "Card Card Task", o etsang liqeto tse kotsi ka 'ho chesa,' kapa ho khannoa ka sepheo sa ho bata, ho etsa liqeto ka boomo. Ba hlokometse hore maemong a 'chesang', bacha ba bontšitse keketseho ea ho beha likotsi ho ba baholo. Haufinyane mohlala ona o atolositsoe ho batho ba banyenyane joalo ka lilemo tsa 10, ka lipatlisiso tse bonts'a hore bacha ba lilemong tsa bocha ba bontša boemo ba ho ipeha kotsing e ka bapisoang le batho ba baholo, le ba ka tlase ho bacha (Figner, Mackinlay, Wilkening, & Weber, 2009). Liteko tsena li tšehetsa maikutlo a hore bacha ba susumetsoa ka mokhoa o sa tobang ho ea ho meputso e ka ba teng, haholo-holo maemong a marang-rang a ho hlasimoloha kapa ho ba boroko.

Hobaneng ha bacha ba bonts'a tšekamelo e kholo ea ho ipeha kotsing? Le ha karabo e le thata ebile e rarollotsoe ke sengoloa se seng bukeng ena (bona sengoloa sa Doremus-Fitzwater, Verlinskaya, & Spear), boits'oaro bo kotsi bo bonoang bocheng bo kanna ba amana le tšusumetso e matlafalitsoeng ea ho batla litšusumetso le liphihlelo tse ncha. Ts'ebetso ena e ka buelloa ke botsitso bo matla ba tšusumetso nakong ena e amanang le bana kapa batho ba baholo (Steinberg, 2008) - ka mantsoe a mang, maikutlo a ho khothatsa (Casey, Getz, et al., 2008; Casey, Jones, et al., 2008; Fareri, Martin, & Delgado, 2008). Tlhaloso ena e lumellana le liphumano tsa boitšoaro bo sa tsoa hlalosoa, ntlafatso e ngotsoeng ea ho batla maikutlo ho bacha ba amanang le bana le batho ba baholo (Zuckerman, Eysenck, & Eysenck, 1978), e hlahisitsoeng e ntle e ama kamora ho fumana moputso oa chelete (Ernst et al. 2005), le bopaki ba nerobiological bo tla tšohloa likarolong tse tlang. Ho khahlisang, litoeba li boetse li bonts'a mokhoa o ntlafalitsoeng oa boqhetseke le maikutlo nakong ea bocha ba bona, ba fanang ka maikutlo a hore boitšoaro bo batlang moputso bo laoloa ke mekhoa ea pele ea bioloji (Adriani, Chiarotti, le Laviola, 1998; Laviola, Macri, Morley-Fletcher, le Adriani, 2003).

Ho batho, tloaelo ena e entsoeng ka "bokhoni ba ho itaola" e isang kotsing e kholo ea boits'oaro bo bobe ba ho ikhethela (Steinberg, 2004). Ha e beoa maemong a hlobaetsang a maikutlo, kutloelo-bohloko e ntlafalitsoeng ea mekhoa e metle ea tikoloho e khetholla boits'oaro ba bongoane ho atamela lits'usumetso, leha khetho eo e ka ba e phahameng kapa e kotsi (Casey, Jones, et al., 2008). Taba ea bohlokoa ke hore boitšoaro bo kotsi bo ke ke ba hlalosoa ke bofokoli ba ho utloisisa litlamorao tsa liketso tsena (Reyna le Farley, 2006). Bacha ba khona ho utloisisa ho beha bophelo ba bona kotsing, empa leha ho le joalo, litemoso tsena ha li eloe hloko, mohlomong ka lebaka la litšusumetso tse fapaneng ho kenyeletsa lithaka, maemo a tikoloho, kapa boemo ba maikutlo ba kahare (Serapa sa jarete le Steinberg, 2005; Steinberg, 2005), e etelletsang pele likhakanyo tsa tikoloho ho 'hapa' holim'a taolo ea kelello maemong a behiloeng maikutlong. Khopolo-taba ena e fana ka maikutlo a hore kutloelo-bohloko e sa arohaneng le mekhoa ea tlhaho ea tikoloho e ka ikarabella bakeng sa keketseho e sa bonahaleng ea boitšoaro bo batlang meputso nakong ena ea kholo.

Le ha o habanya feela, boits'oaro bo kotsi ba bongoaneng bo ka bonahala bo sa lumellane le boiphihlelo ba bocha ba khafetsa ba maikutlo a mabe a maikutlo, mekhoa ena ha ea lokela ho khetholoha (Bogin, 1994; Spear, 2000). Ho joalo, boitšoaro bo bobe le bo tebileng ba maikutlo bo tsamaeang le ho ipeha kotsing e ngata bo ka tsamaisa boitšoaro bo nepahetseng ba ho iphetola ha lintho (Casey, Jones, et al., 2008; Spear, 2000). Ho nka kotsi le ho batla lintho tse ncha ho ka nkoa e le ntho ea bohlokoa ho tse ling tsa lipheo tsa mantlha tsa bohlankana moo batho ba lokelang ho siea malapa a bona - ba "leke" boipuso ba motho, ba hlahise sepheo se lekaneng sa ho hlahloba libaka tse ncha, le ho theha maqhama le bao e seng litho tsa lelapa (ho kenyelletsa bao e ka bang balekane). Matla a ho hlahisa maikutlo a sebetsang le a feteletseng a ka tlatsana le ts'ebetso ena ea ho loanela boipuso. Litla-morao le maikutlo a nyahamisang li ka supa boemo bo phahameng ba ho falimeha mabapi le litšokelo le mekhoa ea polokeho, e ka bang bohlokoa bo boholo ha o le kotsing. Kahoo, kopanyo ea maikutlo le ts'usumetso ea takatso e kanna ea ba teng ka lebaka le letle, empa hajoale setjhabeng ha se sa sebetsa ka sepheo se se fetohelang.

Ho hokahanya mohlala oa phetoho ea boitšoaro ba mocha

Ho ipapisitse le mosebetsi oa boits'ebetso o sa tsoa hlalosoa, re hlokometse lihlooho tse tharo tsa sehlooho tse bonts'ang likarolo tse ikhethang tsa boitšoaro ba bacha, tse amanang le boitšoaro ba bana le batho ba baholo. Taba ea mantlha, bacha ba bonahala ba bonts'a maikutlo a tebileng a lithahasello tse ikhethang tsa tikoloho. Ka boitsoaro, mohopolo ona o tšehetsoa ke litlaleho tsa lefutso tsa ho beha bophelo ba bacha kotsing, le mosebetsi o matla o bonts'a likarabo tse feteletseng litabeng tse ntle tsa bocha tse amanang le bana le batho ba baholo. Se ka bonahala e le ketsahalo e khopisang kapa e utloisang bohloko ho batho ba baholo e ka baka tsitsipano e tebileng ea maikutlo ho bacha e lebisang hotsong e mpe e mpe. Ka mokhoa o ts'oanang, leseli la tikoloho le bonts'ang mohloli o ka bang monate oa thabo ea hedonic le ka susumetsa takatso ea ho batla boitso ho isa bo boholo ho feta ho bana kapa ho batho ba baholo ka lebaka la tlhalohanyo e phahameng ea meputso e ka bang teng.

Sehlooho sa bobeli sebopeho sa boits'oaro ba bongoana ke hore hangata bacha ba sitoa ho fana ka taolo ea boitsoaro ha ba shebana le mekhoa e ikemetseng ea tikoloho, e lebisang ho boits'oarong bo kotsi le bo kotsi ba boits'oaro. Ka ho khetheha, bacha ba khona ho utloisisa le ho beha mabaka ka liqeto tsa liqeto tse nyane. Leha ho le joalo, maemong a nepahetseng, e kanna ea ba ea lithaka kapa maemong a itseng a fetohileng, bacha ba ea litabeng tsa tikoloho le ha ho le kotsi kapa ho ka ba kotsi. Mabapi le ho laola tšusumetso e mpe, ho haella ha taolo ea pele ho ka baka bokhoni bo fokolang ba taolo ea maikutlo, ho hlahisang likarabo tse amehang 'li sa nkuoe' 'me li hlahise tlhahiso e matla ea maikutlo.

Khabareng, le ha bacha ba bonts'a ho phahamela ho arabela ka mokhoa o lumellanang le liphetoho tse thehiloeng boitšisinyong, likarabo tsena li ikhethile haholo lipakeng tsa liphapang tse fapaneng. Ho bonolo ho lebala hore bacha ba bangata ba etsa liqeto tse bohlale, 'me ha ba na bothata ba ho laola maikutlo a bona. Leha ho le joalo, re lumela hore nako ea bocha ke nako ea bophelo e joalo, e lumellanang le maikutlo a teng hajoale ka 'sefefo le khatello ea maikutlo' (Arnett, 1999), sesosa sa kotsi sa maikutlo a phahameng. Karolo ena ea bophelo, e kopantsoe le mabaka a bonts'ang phapang e kang phapang ea motho ka mong pherekanong ea maikutlo kapa maikutlo, kapa maemo a boemo bo kang botsitso ba likamano tsa lelapa kapa tsa lithaka, e ka ba mohloli o mong oa kotsi ea ho ba le maikutlo a tebileng a bonoang nakong ea bocha.

Ho ea mohlala oa methapo ea boitšoaro ea bongoaneng

Re thehile mohlala oa tlhaho o bonts'ang liphetoho tsa boko tse ipapisang le mekhoa ea bongoana e nahanang ho se ts'oanehe ha maikutlo le tšusumetso ea ho batla boits'oaro bo ikhethileng nakong ena (Casey, Getz, et al., 2008; Casey, Jones, & Hare, 2008). Mohlala ona o susumetsoang ke matla o hlahisa ho se leka-lekane pakeng tsa khokahano ea tšebetso le tšebetso ea methapo ea boko e bohlokoa maikutlong le maikutlong a susumetsang (mohlala, likarolo tse ikhethileng tsa litho tsa maoto ho kenyelletsa le amygdala le ventral striatum) ha li bapisoa le lits'ebetso tsa boko tse tsamaisang taolo ea kelello le ho susumetsa (mohlala, senepe sa pele-pele) ua bona Setšoantšo sa 1. Kholo e tsitsitseng ea likarolo tsa maoto le matsoho ha li bapisoa le lets'oao le sa le monyane pele, ho ikarabella bakeng sa boitšoaro bo ikhethileng ba maikutlo le bo susumetsang bo tšoanang le ba bocha. Sena se fapane le mehla ea bongoana, moo lits'ebetso tsa boko ka bobeli li sa ts'oaneng, le ho ba motho e moholo, ha ts'ebetso tsa boko ka bobeli li tsofetse - mme maemong ka bobeli, e leka-lekane haholoanyane tšusumetsong ea bona ea boitšoaro. Karolo e latelang e tla bua ka lipatlisiso tse matla tse hlalosang nts'etsopele ea sebopeho, sebopeho, le tšebetso ea methapo ea boko le taolo ea pele le tšebelisano ea tsona, le hore na ho ba le seabo ha ho leka-lekana ha lits'ebetso tsena ho ka lebisa ho boits'oarong bo khahlisang maikutlong le bocheng bo amanang le bohlankana.

Setšoantšo sa 1 

Mohlala oa boits'oaro bo ntlafalitsoeng bo khothalletsoang le bo thehiloeng mothating oa ho kena bohlankaneng. Pholo-pele ea nako ea libaka tse tlasa subcortical joalo ka amygdala le ventral striatum (khubelu e khubelu), e kopantsoe le nako ea ho fetoloa hoa nako ea libaka tsa preortal cortical (mola o moputsoa), e bolela esale pele ...

Re tla shebana haholo le lits'ebetso tse tharo tsa boko tse sebetsang tseo mesebetsi ea tsona e matla e bohlokoa maikutlong a bongoana, maiketsetso, le boitšoaro bo laoloang ke kelello. Mochine oa amygdaloid, e leng sehlopha sa li-nuclei tse fumanehang mokokotlong oa medial temporous, o bapala karolo ea bohlokoa ho hlahiseng tlhahisoleseling ea bohlokoa ba tlhaho (Aggleton, 2000; Davis le Whalen, 2001; LeDoux, 2000), ho kenyelletsa le tšusumetso ea maikutlo e tšosang, lits'oso tse ka bang teng, le lits'oaetso tse bonts'ang maikutlo a batho ba bang. Sebapali sa bobeli se thata ho poteng ena ke "ventral striatum" e leng karolo ea basal ganglia e nang le li-nucleus accumbens (NAcc). NAcc e kenya letsoho tšebetsong ea ho etsa liqeto ka ho supa tebello le phihlello, mme e sebeletsa ho susumetsa boitšoaro bo susumetsoang ka khokahano le cortex ea pele (Mok'hadinale, Parkinson, Hall, & Everitt, 2002; Delgado, 2007; Schultz, 2006). Kamora moo, cortex ea pele-pele e bile le ts'ebetso mesebetsing e mengata e hlokolosi ea ts'ebetso ho kenyelletsa ts'ebetsong ea taolo ea kelello, taolo ea maikutlo, ho etsa liqeto tse bohlale le ho utloisisa lintho tse rarahaneng (Casey, Galvan, & Hare, 2005; Miller & Cohen, 2001; Ochsner le Gross, 2005). Ke ho leka-lekana pakeng tsa kholo ea bokhabane ba amygdala le NAcc, e amanang le PFC, eo re lumelang hore e hlahisa tloaelo ea boits'oaro bo sa tsotelleng ba maikutlo le taolo ea moputso lilemong tsa bocha.

Ho lekola kholo e fapaneng ea kholo ea libaka tsa maoto le tsa pele

Ntle le lingoliloeng tse sebetsang, ho na le bopaki bo bonts'ang kholo e fapaneng ea kholo ea methapo ea methapo ea maoto joalo ka ha e bapisoa le libaka tsa pele, tse ka buuoang haholo bongoaneng. Bopaki ba ho tsoela pele ho faola ha li-cortical synapses hantle pele ho nts'etsopele bo thehiloe ho li-primates le batho ba se nang botho (Rakic, Bourgeois, Eckenhoff, Zecevic, le Goldman-Rakic, 1986; Huttenlocher, 1997), ka karohano e kholo ea tikoloho e fumanoeng bokong ba motho (Huttenlocher, 1997) joalo ka ha libaka tsa kutlo tsa "cortical sensory" le "subcortical" li kenella ho pruning ea matla pele ho feta libakeng tse hloahloa tsa odara e phahameng. Khopolo-taba ena ea nts'etsopele ea cortical e lumellana le mosebetsi oa MRI oa anatomical o bonts'ang khafetsa oa lintho tse putsoa libakeng tse pele tsa pele tse tsoelang pele ho tloha bocheng (mohlala, Giedd et al., 1999) e amanang le libaka tse haufi. Li-amygdala le li-nucleus tsena li boetse li bonts'a liphetoho tsa anatomical nakong ena ea bophelo empa ho isa tekanyong e nyane. Boitekong ba MRI bo nang le sebopeho, litekanyo tsa bohlooho tsa bokoto ha lia ka tsa boleloa esale pele ke lilemo, ho fapana le libaka tsa pele tse boletsoeng esale pele ka mokhoa o fosahetseng ka lilemo (Sowell et al., 2002). Mabapi le ntlafatso ea nako ea bokhoni ba amygdala, tlhahlobo ea volumetric ea amygdala ea motho e bontšitse sebaka se fokotsoang haholo sa phetoho ea boholo ba libaka tse amanang le libaka tsa 4-18Giedd et al., 1996). Ha li kopantsoe hammoho, liphumano tsena li fana ka maikutlo a tsoelopele ea nako ea pele ea cortex ea mantlha e haufi le libaka tsena tse matla.

Mohlala oa rona o ts'oana le mefuta e meng ea bongoana ea bongoaneng (Nelson, Leibenluft, McClure, & Pine, 2005; Steinberg, 2008). Leha ho le joalo, mohlala oa hona joale o fapane hobane o leka ho ikarabella bakeng sa liphetoho tsa bocha ts'ebetsong ea litakatso le litakatso tse fapaneng, mme o totobatsa tšebelisano e matla lipakeng tsa lits'ebetso tsa boko le tsa cortical bokong ka kakaretso. Qetellong, mohlala oa hajoale o kopanya se fumaneng ho tsoa ho bana, bacha le batho ba baholo hore a ikarabelle bakeng sa tlhaho ea liphetoho tsa bocha tsa bocha, mme o kenyelletsa karolo ea bohlokoa ea phapano ea motho ka mong molemong oa karabelo ea boitšoaro le bokong.

Mekhoa ea methapo ea kutlo e matlafatsang boikemisetsong ba tikoloho

Mekhoa ea ts'ebetso ea neuroimaging e sebetsang e lumella tekanyo e sa senyeheng ea ts'ebetso ea boko ba tikoloho ha lithuto li etsa mesebetsi e etselitsoeng ho khetholla lits'ebetso tsa kelello tsa thahasello. Ho neuroscience e sebetsang, bafuputsi ba sebelisitse mekhoa ea ho hlahisa marang-rang a libaka tsa boko tse shebahalang li arabela ka mokhoa o ikhethileng molemong oa takatso ea takatso le boiphetetso, ho kenyelletsa le amygdala, ventral striatum, midbrain nuclei, medial and lateral preortalal cortices (Adolphs, 2002; Kober et al., 2008). Motho a ka sheba setšoantšo sa nts'etsopele sa nts'etsopele ho bona hore na ho bokellana ha likarolo tsa maikutlo le tse khothatsang tse fetohang e le mosebetsi oa nts'etsopele, boitšoaro le liphapang tsa motho ka mong.

Liteko tse 'maloa tsa morao-rao tsa tlhahlobo-leseling li hlokometse mofuta oa ho arabela ka mokhoa o ikhethileng ho litakatso tse sa tsitsang tsa tikoloho nakong ea bocha. Mosebetsi oa pele oa sehlooho sena o tlalehiloe hore bacha ba bonts'a karabelo e tšepahalang ea maikutlo a sefahleho, ho kenyelletsa le lifahleho tse tšosang (Baird et al., 1999). Liteko tsa morao-rao tse kenyeletsang sehlopha sa batho ba baholo ba bapisang sehlopha li tlalehiloe hore bacha ba phahamisitse ponahalo e kholo ea maikutlo a sefahleho ho batho ba baholo ba seng ba sa sebetse (Guyer et al., 2008a; Monk et al., 2003). Leha ho le joalo, ho lokela ho hlokomeloa hore phello ena ha e e-so bonoe kamehla, joalo ka Thomas le basebetsi-'moho (2001) ho tlalehiloe keketseho ea karabelo ea amygdala ho se nke lehlakore ho amanang le sefahleho se tšabehang mohlaleng oa pele ho lilemo tsa bocha, litlamorao tse fapaneng le tse bonoang ho batho ba baholo. Ntle le moo, ho na le bopaki bo bong ba hore karabelo ea amygdala ho bacha e ka ikemela ka mokhoa o ikemetseng, kaha bacha le bona ba bonts'a ts'ebetso ea amygdala e thabileng mabapi le sefahleho se sa nke lehlakore (Williams, et al., 2006), e lumellanang le se bonoang ho batho ba baholo (Somerville et al., 2004).

Haufinyane tjena, lipatlisiso li shebile ho latela liphetoho lipotsong tsa neural ho maikutlo a maikutlo nakong ea phetoho ho kena, nakong ea bocha le ho tsoa bohlankaneng (Casey, Tottenham, Liston, & Durston, 2005) molemong oa ho fumana litlamorao tse sa amaneng nakong ena ea bophelo. Ka ho leka batho ba pakeng tsa lilemo ho tloha bongoaneng ho fihlela ho ba batho ba baholo, ho ile ha bonoa hore boholo ba karabelo ea amygdala bo ne bo le kholo haholo ho bacha lilemong ha bo bapisoa le bana bana le batho ba baholo, ba bonts'itseng ho ts'oaroa ha amygdala ho latela maikutlo a sefahleho (Hare et al., 2008, bona Setšoantšo sa 2A). Lithuto tsena le tse ling li lebisitse qetong ea nakoana ea hore bacha ba bonts'a mokhoa o fetelletseng oa karabelo ea amygdala ponahalong ea sefahleho sa bana le batho ba baholo (Somerville, Fani, & McClure-Tone, ho boralitaba). Leha ho le joalo, mekhoa ena ha e nahanoe e sa sebetse ponahalong ea sefahleho, joalo ka ha ho bontšitsoe meputso e meng e meholo e kang ho siuoa ha moputso o moholo oa chelete ho hlahisa likarabo tse kholo tse sa lekanyetsoang ho bacha ba lilemong tsa bocha le batho ba baholo.Ernst, et al., 2005).

Setšoantšo sa 2 

(A) Karabelo ea Amygdala ponahalong ea sefahleho sa maikutlo e ne e le kholo haholo ho bacha ho feta bana kapa batho ba baholo. E fetotsoe ho tsoa Hare et al., 2008, Likokoana-hloko tsa likokoana-hloko. (B) Karabelo ea nyutlelie ea ho fumana moputso o moholo oa chelete e ne e le haholo ...

Mekhoa ea ts'ebetso ea ts'ebetso ea ts'ebetso ea morao-rao e boetse e lekotse botebo ba neural ba bokhoni bo ntlafalitsoeng ba bacha ho lithahasello tsa takatso ea lijo ka ho sebelisa phapang ho mesebetsi e amanang le tšusumetso e amanang le ts'usumetso, moo khetho ea boits'oaro ea lithuto e khethileng ho hloloa kapa tahlehelo ea chelete le / kapa boholo ba moputso. Liteko tsena li shebile tšebetso ea "ventral striatum" e amehang ho putsa tebello le ho ithuta ho motho ka mong (Delgado, Nystrom, Fissell, Noll, & Fiez, 2000; Knutson, Adams, Fong, & Hommer, 2001; O'Doherty, Deichmann, Critchley, & Dolan, 2002) le phoofolo (Schultz, Dayan, le Montague, 1997). Mots'eanong le basebetsi-'moho (2004) lekile karolo ea bacha nakong ea papali ea papali ea papali ea chelete eo ba ka e hlolang kapa ba lahleheloa ke chelete tekong e 'ngoe le e' ngoe, ba ntse ba hlahloba mesebetsi ea neural ho e lokisa. Ha ba bapisa liteko tsa tahlehelo ea tahlehelo le tahlehelo, barupeluoa ba neng ba le lilemong tsa bocha ba ile ba khetha likarolo tse tšoanang le tsa bongo ho se neng se bontšitsoe pele ba sebelisa mosebetsi o le mong ho batho ba baholo.Delgado, et al., 2000), ho kenyelletsa mosebetsi o phahamisitsoeng ho "ventral striatum" Ho khahlisang, mokhoa oa "" "oa" nako ea moputso oa karabelo o atolositsoeng ka nakoana ho bacha ho bapisoa le batho ba baholo (Fareri, et al., 2008), ho fana ka tlhahiso ea ho fetelletsana hoa nakoana litabeng tsa ho hira melemo ea litheko ho fumana meputso. Re sebelisa mosebetsi o mong oa papali ea chelete, Ernst le basebetsi mmoho (2005) lekanya ts'ebetso ea neural le likarabelo tse ikhethileng tsa karabo ho hlolang le tahlehelo nakong ea ho hlahlojoa ha fMRI. E amanang le batho ba baholo, bacha ba tlaleha ho eketseha hoa thabo e tlisoang ke thabo ha ba hapa moputso o moholo, 'me liteko tsena tse kholo tsa meputso li ile tsa hlahisa likarabo tse fetelletseng tsa neural ka har'a NAcc. Ha li kopantsoe, liteko tsena tse peli li tšehetsa taba ea hore bacha ba bontša boikemisetso bo matla ba ho amohela litheko, ka bobeli mabapi le boits'oaro le likarabo tse tsoang ho batho ba bang (cf Bjork, et al., 2004).

Boithuto bo tsoang laboratoring ea rona bo ile ba lekola liphetoho phetohong ea neural ho litekanyetso tsa takatso ea lijo ho barupeluoa ba lilemo tse fapaneng ho hlahloba liphetoho tsa karabelo ea neural ho li susumetsa nakong ea phetoho ho kena le ho tsoa bongoaneng. Galvan le basebetsi mmoho (2006) e tlalehiloe ka likarabo tsa neural baneng, lilemong tsa bocha le ho batho ba baholo nakong ea moputso oa ho ithuta paradigm e lefang litšusumetso tse nyane, tse mahareng le tse kholo. Bacha le batho ba baholo, NAcc e bonts'itse ts'ebetso e ntseng e eketseha e le ts'ebetso ea sephetho sa moputso, ka meputso e meholo e phahamisang ts'ebetso e kholo ea NAcc (bona Setšoantšo sa 2B). Bana ba bontšitse karabelo e sa kopaneng ea NAcc, ho se na phapang ea ts'ebetso ho pholletsa le maemo a phahameng, a mahareng le a phahameng moputso. Leha ho le joalo, ho NAcc, bacha ba bontšitse keketseho karabong ena e thehiloeng ho boholo, ka matlafatso e kholo ho arabeleng moputso o moholo oa chelete o amanang le bana le batho ba baholo. Hypersensitivity ena ea biolo ea ho fana ka moputso ho dolescents e bontšitsoe lithutong tse 'maloa tse eketsehileng (Ernst et al., 2005; May et al., 2004) hape e fana ka maikutlo a ho sebetsa ka botlalo ho karabelo ea Nacc ea bongoana ha e bapisoa le bana, ka mekhoa eohle ea karabelo e tšoanang le ea batho ba baholo, empa e le ka mokhoa o fetelletseng.

Mekhoa ea brain ea taolo e tlase ea taolo ea likarabo ho litekanyetso tsa bohlasoa ho bacha

Phetoho e 'ngoe ea bohlokoa sebopeho sa boko e etsahala ka har'a lipampiri tsa lintho tse tšoeu, likhahla tsa li-axel tsa myelinated tse tsamaisang matšoao a neural lipakeng tsa boko (Cascio, et al., 2007). Ho fapana le taba ea bohlooho, litsela tse tšoeu li bonahala li ntse li eketseha ka boholo, letsoalo le boits'oaro ho tloha lilemong tsa bocha le ho ba motho e moholo.Schmithorst, Wilke, Dardzinski, le Holland, 2002; Snook, Paulson, Roy, Phillips, & Beaulieu, 2005). Ho khahlisang haholo ke ho ts'epahala ha lipampiri tsa taba tse tšoeu lipakeng tsa likarolo tse sa sebetseng le bokong ba pele, kaha litsela tsena li ka tsamaisa puisano lipakeng tsa maikutlo le lipallo tse tsamaeang pele le libaka tse laoloang pele (Hare le Casey, 2005; O # x00027; Doherty, 2004; Pessoa, 2008; Phelps, 2006).

Mosebetsi o ntseng o hola oa bokellana ho fana ka maikutlo a hore ts'ebetso ea ts'ebetso ea litaba tse tšoeu tsa subcortical-cortical white pathways ho sa tsotelehe tsa lilemo li amana le boitšoaro le litšobotsi tsa botho tse amanang le moputso le ts'ebetso ea maikutlo. Kim le Whalen (2008) haufinyane tjena li bonts'itse hore matla a khokahano pakeng tsa amygdala le "cortex" ea li-activation tsa pele li bolela matšoao a fokolang a ho tšoenyeha lithutong tsa batho ba baholo ba phetseng hantle, tumellanong le litlaleho tse fetileng tse supang tsela e ts'oanang ea amygdala-PFC (Johansen-Berg et al., 2008). Mohlomong khokahano lipakeng tsa sebopeho le botho e ka hlalosa ho se tšoane hoa boits'oaro bona bongoaneng, moo khokahano ea litaba tse tšoeu e shebahalang e le mahareng le e fapaneng hara batho ka bomong.

Ho sebelisa mohlala oa nts'etsopele, Liston le basebetsi-'moho (2006) e tlaleha hore lipampitšana tse 'maloa tse tšoeu li bonts'itse phetiso e tsoelang pele ho nako ea bocha, ho kenyelletsa le lipampitšana pakeng tsa cortex ea pele le prerial. Ho lipampitšana tse hlahlojoang, ke kholo feela ea tsela ea "ventral frontostriatalway" e boletsoeng esale pele taolo e ntle ea tšusumetso, e lekantsoeng ka boikitlaetso mosebetsing o sa tsamaeng letho (Liston, et al., 2006). Ha li kopantsoe hammoho, lithuto tsena li fana ka bopaki bo makatsang ba hore litsela tse tšoeu tsa cortical-cortical white li ntse li tsoela pele ho fetoha ka sebopeho lilemong tsa bocha le hore katleho ea taolo ea kelello, ka karolo e 'ngoe e its'etleha ho kholo ea likhokahano tsa frontostriatal. Sena se kanna sa bakoa ke bokhoni ba ho laola litšusumetso ha o shebana le meputso e ka ba teng. Boithuto ba nako e tlang bo amanang le thepa ea lipampitšana tsa litaba tse tšoeu ho litšoaneleho tsa botho le bokhoni ba kelello bo teng mehlaleng ea nts'etsopele li ka lumella kutloisiso e kholo ea karolo ea khokahano e holimo-tlase le tlase botebong ba boits'oaro bo susumetsoang ke maikutlo.

Lithuto tse tšohliloeng karolong e fetileng li bonts'a hore bacha ba ka bonts'a "ts'usumetso e matla" lithahasellong tse ling tsa tikoloho. Setšoantšo se felletseng haholoanyane sa kholo ea maikutlo a bongoana e nahana ka tšebelisano pakeng tsa lits'ebetso tse amehang le taolo bokong ha ho hlokahala hore li hatelle, li hlokomolohe, kapa li thibele karabelo litakatsong tsa maikutlo. Taolo ea kelello e ka hlalosoa e le bokhoni ba ho boloka kelello e lebisitsoeng ho sepheo ha motho a e-na le tlhaiso-leseling, 'me nts'etsopele ea eona le likarolo tsa neural li buisanoa nako e telele ho sengoloeng se seng bukeng ena (Luna et al, makasine ona). Leha ho le joalo, taolo ea kelello e bohlokoa hape ho ts'ebetsong maikutlong le ts'usumetso, hobane ho thata haholo ho bacha ho boloka taolo ea kelello ha ba shebane le maikutlo a tšusumetso kapa a susumetsang maikutlo (Eigsti et al., 2006). Ha barupeluoa ba phetseng hantle ba botsoa hore ba hatelle likarabo tsa bona tse amanang le litheko tsa tikoloho, ts'ebetso e ntlafalitsoeng hangata e bonoa li-cortices tse tsamaeang ka maoto le tsa kalafo.Ochsner le Gross, 2005; Urry et al., 2006). Ho bokelloa ha mongolo oa cortex ea ventromedial prefrontal ho ka sebetsa e le ponelopele ea neural bakeng sa maloetse a kelello a kang khatello ea maikutlo (Johnstone et al., 2007), ketsahalo eo e phahamisoang nakong ea bohlankana. Khokahano pakeng tsa lits'ebetso tsa maikutlo le temoho e sehlohlolong sa mohlala oa rona, mme re tiisa hore bacha ba bonts'a mokhoa o sa leka-lekanang oa mesebetsi ea neural e ka amanang le bofokoli ba boitsoaro bo sitisang karabelo ea maikutlo ka katleho.

Liphuputso tse sebetsang haholoanyane tsa neuroimaging lia hlokahala ho hlakisa tšebelisano lipakeng tsa maikutlo le taolo e laoloang bohlankeng ba bocha, empa lithuto tsa pele li fane ka leseli la bohlokoa lipuisanong tsena. Phuputso e entsoeng ke Khoele le basebetsi-'moho (2003) bapisa liketsahalo tsa neural tsa bacha ba kenang lilemong tsa bocha le ba baholo ha ba ntse ba talima maikutlo a tšosang le a sa nke lehlakore. Ha ba ntse ba shebile lifahleho, barupeluoa ba neng ba shebelletse feela kapa ba ile ba botsoa hore ba tlohele ho sheba sefahleho, 'me ba lekanye maikutlo a bona. Tekanyetso ea boemo ba maikutlo e ne e nahanoa hore e hloka phetoho ho tsepamise maikutlo hole le sebopeho sa sefahleho, e re ho eketsoe ntlafatso ea lits'ebetso tse laoloang boteng ba maikutlo a maikutlo. Batho ba baholo ba ile ba bokella "cortex" ea pele ho pele, e fumanehang sebakeng sa boemo bo tlase haholo ho feta ba lilemong tsa bocha nakong ea liteko tse hlokang ho fetoha hoa tlhokomelo, ha ho hlahisoa lifahleho tse tšosang. Bangoli ba fetoletse ho fumana sena e le sesupo sa bokhoni ba batho ba baholo ba ho bokella libaka tsa pele ho tsa pele hore ba se ke ba tsepamisa maikutlo lipakaneng tsa kahare, athe bacha ba hapile ts'ebetso ena ka mokhoa o sa sebetseng. Ho shebella ha sebaka sa pele sa ts'ebetso ea pele ea ts'ebetso hoa khahla ebile ho ka bontša phapang e kholo lipakeng tsa paradigm ena le tse hlahisitsoeng likarolong tse qetellang. Mohlala, boitekong bona, ts'ebetso e ne e sa tsamaellane le mofuta ofe kapa ofe oa boits'oaro ba ho nyahama, ho bolelang hore bacha ba ka sebelisa mekhoa e fapaneng ea kelello ho phethela mosebetsi o amanang le batho ba baholo. Ho tla ba bohlokoa mosebetsing oa nako e tlang ho kenyelletsa sampole e nang le boits'oaro bo botle le tse nang le tšebetso e hlophisitsoeng ho theosa le lilemo (ho ka etsahala ho supa tšebetso ea kelello e teng) ho nts'etsapele ho hlalosoa ha litlamorao tsa tsoelopele (joalo ka Schlaggar et al., 2002).

Hare le basebetsi mmoho (2008) Ntle le moo, e lekoa hore na ho na le mekhatlo e lipakeng tsa subcortical limbic le frontal tse kentsoeng taolong ea kelello. Ts'ebetso ea puisano e sebetsang e bonts'a sebaka sa "cortex" ea ts'ebetso ea mantlha ea semmuso le ho fokotsa nako ea karabelo nakong ea tlhahlobo. Ha ba hlahloba kamano ena ho fihlela nts'etsopele, bacha ba hirile cortex ea pele ea bongoaneng ea batho ba baholo. Ka mantsoe a mang, thuto ena e ile ea hokahanya kamano pakeng tsa ho hira ea cortex ea pele ea boemo bo holimo, ho fetelletsa litaba tsa Amygdala le ts'ebetso e liehang - mme mokhoa ona e ne e le tšobotsi ea bacha. Ka kakaretso, liphuputso tsena li fana ka maikutlo a hore khokahano ea tšebetso ea maoto le methapo e thusa ho fana ka taolo ha motho a e-na le maikutlo, 'me bacha ba bontša ho hloaea matsoho le ho khetholla pele. Ho se leka-lekane hona ho sebetsang ho fella ka ho se sebetse hantle ho etseng ketso e lebisitsoeng ho sepheo moo ho nang le litakatso tsa maikutlo.

Ha a bapisa liphetho tsena molemong oa ts'ebetso ea ts'ebetso ea ts'usumetso, Galvan o boetse a tlaleha ho haptjoa ha Orbitofrontal cortex (OFC) mohlaleng o kenyelletsang bana, bacha le batho ba baholo. OFC ke karoloana ea "cortex" ea mantlha e bontšitsoeng ho batho ba baholo ho emela maemo a tšohanyetso le taolo ea thibelo e thibelang litšusumetso tse amanang le moputso (Daw, O # x00027; Doherty, Dayan, Seymour, & Dolan, 2006; Galvan, et al., 2005;; bona Rolls, 2000 bakeng sa tlhahlobo). Galvan le basebetsi-mmoho ba tlalehile hore lilemong tsa bocha, OFC e ile ea eketseha ha e amoheloa moputso oa chelete (Galvan et al., 2006), joalo ka se hlokometsoeng litlalehong tsa pejanaMay et al., 2004). Ntle le moo, bacha ba bonts'itse mekhoa ea ts'ebetso ea OFC e neng e ts'oana le bana ho feta batho ba baholo, ho fapana le boholo ba ts'ebetso ea NAcc, hore lilemong tsa bocha ho ne ho tšoana le ba baholo. Ts'ebetso e khelosang tikoloho ho OFC e tlalehiloeng ke Galvan le basebetsi mmoho le NAcc e sebetsa e le sesupo sa ts'ebetso ea ho se sireletsehe hoa boko (Durston, et al., 2006), e fana ka bopaki bo eketsehileng ho se sireletseheng ho sebetsang ha cortex ea pele nakong ea lilemo tsa bocha e amanang le mokhoa oa pejana le o tsepameng oa tšebetso ea NAcc e hlokometsoeng lilemong tsena.

Qetellong, lits'ebetso tsa subcortical tse bohlokoa bakeng sa ts'ebetso ea moputso, ho kenyelletsa le ventral striatum le amygdala, li bontša likarabelo tse matla mabapi le maikutlo le moputso oa likhahla tse khahlisang tse amanang le bana le batho ba baholo. Likarabo tse feteletseng tsa neural libakeng tsena li tšehetsa mohlala o boletsoeng pejana, moo lipontšo tsa maoto le litheko li leng kholo ka tsela e sa lekanang lilemong tsa bocha. Ho fapana le ho phahama ha likarabo tsa khatello ea maikutlo le tšusumetso tse tlisoang ke ts'ebetso ea mokokotlo, ts'ebetso ho cortex ea pele e bonts'a mokhoa o fapaneng oa tsoelo-pele. Mohlala oa rona o ts'ehetsa hore "cortex ea pele" e fetoha tlholeho ea morao-rao ka nako ea morao-rao, e ts'ehetsoang ke datha ea sebopeho le ts'ebetso e sa tsoa hlalosoa. Sebetsa ho fihlela joale se tšehetsa haholo taba ea hore cortex ea pele e ntse e sebetsa maemong a bosa nakong ea lilemo tsa bocha, 'me e fana ka taolo e tlase taolong bakeng sa libaka tse tlasa hanyane tsa batho ba baholo. Keketseho e matla ea likarabo tse ikhethileng ho likaroloana tse ikhethang tsa tikoloho, e entsoe ka tsamaiso e sa laoleheng ea kemiso, e kanna ea ikarabella bakeng sa liphetoho mokhoeng oa bocha, mme e ka ikarabella bakeng sa tlhoro e sa tsejoeng ea ho batla tšusumetso le boits'oaro maikutlong hangata bo bonoang ho bacha.

Phapang e fapaneng le e 'ngoe e khetholla karabelo ea khokahano ea subcortical-cortical

Liteko tse sa tsoa hlalosoa li fana ka maikutlo a hore bacha ba bontša ho arabela ka mokhoa o ntlafalitsoeng ho lithahasello tsa tikoloho, hammoho le likarabo tse fokotsang tsa pele ho maemo maemong a hlokang taolo ea kelello. Leha ho le joalo, tlhaiso e bonolo ea lintlha tsa data tse tala tse emelang karabo ea amygdala ho Setšoantšo sa 2A, 'me karabelo ea li-bokellase e bontšoa ho Setšoantšo sa 2B, e bontša ka ho hlaka hore ho na le phapano ea motho ka mong karabong tsena. Ho conceptualization ea rona, bohlankana ka bo bona ke sesosa sa ts'ebetso ea 'ho se leka-lekane' ho sebetsang ho boletsoeng pele, empa lintlha tse ling tse fapaneng li ka sebetsa hape e le babuelli ba matla ba karabelo ea subcortical-cortical (Bona. Setšoantšo sa 3). Liphapang tse joalo ka bomong li ka ba sebopeho se tsitsitseng sa botho, phapang lipapisong tsa methapo ea methapo, liphetoho tse laoloang ke tlhaho ea lihormone kapa litlamorao tse ling tsa boroetsana, le maemo a bophelo, a kang boemo ba motho sechabeng.

Setšoantšo sa 3 

Boemeli bo rerileng ba lilemo le liphapang tsa motho ka mong e le lintlha tse ka bakang kotsi ea ho bolela esale pele boitšoaro bo botle ba maikutlo le bo kotsi ho bacha.

Bohlokoa ba liphapang tsa motho ka mong e le moetapele oa 'ho leka-lekana' ho marang-rang a subcortical-cortical a bontšitsoe maemong a liteko a mangata, ho kenyelletsa le liteko tse ling tse hlalositsoeng pele. Hare le basebetsi mmoho (2008) e bonts'itse hore karolo e kholo ea karohano karabong ea amygdala ho maikutlo a mabe e tlalehiloe ke liphapang tsa batho ka bomong ba sa tsotelleng lilemo, e lumellanang le litlaleho ho batho ba baholo ba bontšang hore matšoenyeho a etsa hore motho a be le moea o mong o fapaneng le oa methapo ea methapo (Etkin et al., 2004; Somerville et al., 2004; Stein et al., 2007). Mabapi le ts'ebetso ea ts'usumetso, Galvan le basebetsi-mmoho ba bonts'itse hore ho theosa le lilemo, karohano e kholo ea karabelo literekeng tse lebelletsoeng tsa moputso o moholo e boletsoe ke monyetla oa nnete oa ho etsa boits'oaro bo kotsi (Galvan et al., 2007). Lithuto tsena li fana ka bopaki ba pele ba hore phapang ea motho ka mong, eo hangata e sa lekanoang, e ka bapala karolo ea bohlokoa ho arabeleng maikutlo a neural ho lithahasello tse amanang le tšusumetso ho bacha, 'me likarolong tse qetellang re tla hlahloba mehloli e meng ea tlhabollo eo. e ka boela ea fetola litlamorao tsena. Puisano ea liphapang tse fapaneng tsa motho ka mong, ho kenyelletsa ho fapana ha thepa ea neurotransmitter ho nts'etsopele (haholo bakeng sa tsamaiso ea dopaminergic) e ka fumaneha sengoloeng se seng bukeng ena (Wahlstrom et al., Makasine ona).

Karolo ea li-hormone tsa gonadal tšebetsong e sebetsang le e khothalletsang bokong ba bocha

Mohloli o mong o ka bang le tšusumetso ho "ho leka-lekana 'ha karabelo ea subcortical-cortical ke liphapang tsa motho ka mong maemong a lihormone tsa" pubertal ". Nakong ea bocha ho na le keketseho e kholo ea li-hormone tsa gonadal tse potolohang, tse qetellang li lebisa tšebetsong ea thobalano ea thobalano (Spear, 2000). Litlamorao tsa 'mele oa Gonadal bokong li hlalositsoe e le mekhoa ea "mokhatlo" eo li-hormone tsa thobalano li bakang liphetoho tse sa feleng litsamaisong tsa neural tse fetolang boitšoaro, kapa mekhoa ea "activative" eo ho eona lihormone tsa thobalano li nang le ts'usumetso ea liphetoho tse mpe mme litlamorao li fetoha hang ha li-steroid li. li tlositsoe (Cooke et al., 1998). Morero o ntseng o atile ke hore litlamorao tse mpe tsa li-hormone tsa thobalano nakong ea bocha li ka ts'oaroa ho potoloha hoa li-neural ho kenella ts'ebetsong ea li-hormone, tseo ka nako e 'ngoe li lumellang kholo le boits'oaro ba boits'oaro bo botle ba thobalano le bohlolaRomao, Richardson & Sisk, 2002; Sisk & Zehr, 2005; Steinberg, 2008). Ka mantsoe a mang, lilemo tsa bocha e ka ba nako e mahlonoko bakeng sa lihormone tsa gonadal ho susumetsa litlamorao tsa mokhatlo, tse tsamaisang boitšoaro ba bophelo le ho ikatisa - mme mohlomong, boits'oaro bo khahlisang maikutlo le bo susumetsang ka tekanyo e kholo.

Litorphphism tsa thobalano li tlalehiloe ka phetoho ea lefatše ka sebopeho sa boko (Giedd et al., 1997) hammoho le li-trajectories tse fapaneng bakeng sa phetiso ea amygdala le striatum (Caviness et al., 1996; Giedd et al., 1997, Schumann et al., 2004). Kahoo, liphetoho tse bang teng maemong a lihormone li ka ba teng tlhahisong ea boko nakong ena ea bophelo le liphetoho tsa boits'oaro bo amanang le eona. Ho bashanyana (lilemo tsa 8 - 15yrs), litekanyetso tsa basal tse phahameng tsa testosterone tse amanang le ho eketseha ha molumo ho amygdala (Neufang et al., 2009). Phuputso ena ea morao-rao e bonts'a hore li-hormone tsa gonadal li kanna tsa ba le litlamorao ho ts'ebetso ea libaka tse bontšitsoeng li amohela litaba tse hlasimolohileng maikutlong. Hobane bocha ke nako eo ka eona litekanyo tsa lihormone li phahamisoang (Norjavaara et al., 1996), ho ka etsahala hore lihormone tsena li sebetse e le mohato oa bohlokoa phapusing ea maikutlo le maikutlo a khothalletsang boits'oaro le boits'ireletso ho bacha.

Boithuto ho bacha bo boetse bo bontša khokahano lipakeng tsa liphetoho tsa lihormone le boits'oaro ba sechaba. Ho bashanyana ba lilemong tsa bocha, maemo a tlase a testosterone le testosterone a neng a fokotseha butle ka nako ea mots'eare a ne a e-na le maemo a mangata a ho tšoenyeha, khatello ea maikutlo le mathata a ho tsotella ho sa natsoe ka tsoelo-pele ea mafu, ha a le banana ba lilemong tsa bocha, o fokotseha ka sekhahla ka testosterone nakong ea letsatsi e kopantsoeng le boitšoaro bo boholo bo sitisang (Granger et al., 2003). Ho bashanyana le banana ba lilemong tsa bocha, ho eketseha ho matla ha li-hormone tsa gonadal ho amana le kamano e matla le lithaka tse ipehang kotsing (Vermeersh et al., 2008a; Vermeersh et al 2008b) le puso e phahameng ea sechaba (Schaal et al., 1996) e fana ka maikutlo a hore tikoloho ea sechaba le li-hormone tsa gonadal li ka sebelisana ho bolela ho se tšoane ho itseng ho khothatsong le boits'oarong ba sechaba.

Le ha ho ka ba le kamano lipakeng tsa li-hormone tse feto-fetohang tse susumetsang boitšoaro, ho bohlokoa hape ho nka karolo ea liphatsa tsa lefutso tsa gonadal, tse sebetsang ka ho potoloha li-hormone tsa gonadal. Phuputso ea morao-rao (Perrin et al., 2008) e bontsitse phapang ea palo e tšoeu ea taba ho bashemane ba lilemong tsa bocha e ne e sa kenngoe feela ka maemo a testosterone empa ka genetic polymorphism ho mofuta oa androgen receptor (AR), hoo bashanyana ba nang le mofuta o mokhuts'oane oa AR ba nang le lipalo tse phahameng tsa testosterone ba bile le keketseho e kholo litabeng tse tšoeu molumo ho feta tse nang le mofuta o molelele oa AR. Sena se fana ka maikutlo a karolo ea bohlokoa ea liphatsa tsa lefutso ho utloisisa litlamorao tsa tšebetso le mokhatlo.

Tšusumetso ea lithaka ts'ebetsong e anngoeng le e khothalletsang bokong ba bocha

Kamano le lithaka e nka taba ea bohlokoa haholo bocheng (Steinberg, 2005), ho e fana ka mohloli o ka thusang lipakeng tsa liphetoho lipakeng tsa boits'oaro bo khothatsang le bo khothalletsang. Ka lehlakoreng le leng, bacha e le sehlopha ba ka bonts'a maikutlo a ntlafalitsoeng a mekhoa e metle ea boithabiso, haholo-holo e hlahisoang ke lithaka, ha e bapisoa le batho ba baholo le bana. Ntle le moo, liphapang tse fapaneng le tsa batho ba bang ka maikutlo a lithaka li ka sebetsa ka ho khetheha ho khetholliseng boitšoaro ba bacha.

Boithuto ba morao-rao bo lekile ho utloisisa tšusumetso ea lithaka mabapi le karabelo ea boitšoaro bo bobe le litloaelo tse tsoang ho mekhoa e loketseng e lumellanang. Grosbras et al. (2007) ho tlalehiloe bacha ba neng ba hanana le tšusumetso ea lithaka ba ne ba ena le tšebetso e fokolang ea dorsal premotor cortex ha ba ntse ba shebelletse ho sisinyeha ha matsoho le sefahleho se bohale, ho fapana le ba hanyetsang tšusumetso e mpe ea lithaka. Sena se khothalelitse batho ba amehileng haholo ka khatello ea lithaka ba ka ba le keketseho ea ho hlophisoa ha makoloi ho sisinyeha ka bohale mme ba ka lebisa tlhokomelo e eketsehileng ha ba shebella leseli le sa hlokeng maikutlo. Guyer le al. (2008b) e tlaleha hore bacha ba lilemong tsa bocha ba sebelisanang le lithaka tse phahameng le tse tlase tse kenang moqoqong oa ho qoqa le ba bang ba ne ba e-na le ts'ebetso e kholo ho maqhubu a nyutlelie, hypothalamus, hippocampus le insula ho bapisoa le lithaka tse phahameng tse phahameng. Likarolo tsena kaofela, ntle le ts'ebetso, li bile le keketseho e amanang le lilemo bakeng sa ho fana ka tlhahiso ea likarolo tse lumellanang le moputso ho lithaka tse lakatsehang sechabeng. Liphumano tsena li hlahisa lits'ebetso tsa moputso tse boletsoeng pejana e le li ka arolelanang bofokoli ba litšebelisano tsa kahisano nakong ea bohlankana.

Ka bobeli lithuto tsena li lekile ho hlakisa motheo oa neural oa ts'usumetso ea lithaka ts'ebetsong ea likamano, leha ho le joalo li na le bokhoni ba tsona ba ho tsebisa likarabo tsa neural nakong ea lipuisano tsa sebele tsa sechaba. Ka mantsoe a mang, nakong ea liteko tseo re sa tsoa buisana ka tsona, barupeluoa ha ba lumele hore ba hlile ba kena lipakeng le lithaka. Mosebetsi ho batho ba baholo o lekile ho etsisa litšebelisano tsa 'nete tsa bophelo ba kahare ho skena sa fMRI le ho lekanya likarabo tsa neural ho kenyeletsong le ho khetholloeng ha sechaba (Eisenberger et al., 2003; Somerville et al., 2006). Hona joale, mosebetsi o ntse o tsoela pele oa ho ntšetsapele lipuisano tseo ho tsona bacha ba ithutang kapa ba nang le phapanyetsano ea sebele ea sechaba, 'me e tla ba ho khahlisang ho lekola tlatsetso ea libaka tsa boko meputsong le meputsong e nepahetseng bakeng sa ho loants'a boitšoaro ba sechaba le ho lekola sephetho sa litšebelisano tsa lithaka.

Caveats le meeli

Patlisiso e sa tsoa hlalositsoe, e entsoeng haholo lilemong tse hlano tse fetileng, e nkile mehato e makatsang bakeng sa ho khetholla maikutlo le karabelo mohopolong oa bongoaneng. Leha ho le joalo, ho lokela ho bontšoa hore palo ea liteko mabapi le sehlooho sena e ntse e fokola haholo mme ho lokela ho nkuoe tlhokomeliso ha ho etsoa liqeto tse sa utloahaleng ho bona. Boithuto bo eketsehileng bo nang le mehlala e meholo ea sampuli bo reretsoe ho hlakisa ka botlalo sebopeho sa tšebelisano ea maoto le maobane pele ho kamano ea bona le boits'oaro ba bongoaneng. Ntle le moo, ho leka bana, bacha le lithuto tsa batho ba baholo tekong e le 'ngoe ho bohlokoa bakeng sa ho khetholla liphetoho tse sa tsamaellanang, hobane bacha ba lebelletsoe ho fapana le lihlopha ka bobeli. Sena ha se lekolwe hangata tekong e le 'ngoe.

Mabapi le ts'ebetso ea bohato ba boqhetseke le bohlong ba banyane lilemong tsa bocha, bopaki bo fetohile hantle ho ts'ehetsa mohopolo oa hore litsamaiso ka bobeli li bonts'a karabelo e fetelletseng ea bongoaneng. Ho utloisisa moputso oa bongoana le boits'oaro ba maikutlo, mekhoa ea taolo ea pele e lokela ho tsotelloa, empa liteko tse fokolang li hlahlobe karolo ea karolo ea pele ho ho laola mekhoa ena. Ntle le moo, liteko tse ngata li buile ka likarabo tsa pele le ka mokhoa o sa nepahalang ho latela hore na sebaka se itseng se kahare ho cortex ea pele se ne se sebetsa ebile se buisana ka litaba tsa sona. Cortex ea pele ke sebaka se seholo sa boko se nang le likarolo tse ngata tsa tlhaho tse fapaneng tsa ts'ebetso, boqapi, liphetho le liphetho. Mosebetsi oa nako e tlang, ho batho ba baholo le ba lilemong tsa bocha, o kanna oa lumella kutloisiso e kholo ea karohano ea mantlha le kamano ea bona ea tšebetso ea maqhubu le ea boqapi nakong ea kholo.

Nahanisisa

E amanang le batho ba baholo le bana, bacha ba etsa boitšoaro bo kotsi bo sa ts'oaneng, bo ka lebisang liphellong tse mpe tse fapaneng tse kenyelletsang tlhekefetso ea lithethefatsi, thobalano e sa sireletsehang, likotsi le ho ipolaea. Bongata ba boits'oaro bona bonyane bo arotsoe ka karabelo ea maikutlo le maikutlo, ekaba boitšoaro bo sa lokelang ba ho lebisa tseleng e kotsi ea meputso e ka bang teng, kapa sephetho sa ho ba le ts'usumetso e mpe joalo ka ho intša kotsi le ho ipolaea. Boitšoaro bo amanang le maikutlo le ts'usumetso bo hokahane haufi le likotsi tsena, mme ho utloisisa karolo ea ho theha lits'ebetso tsa boko ho hokahaneng le boits'oaro bona ho bohlokoa haholo ho bophelo bocha.

Lithuto tsa sebopeho sa batho tsa sebopeho le tšebetso li se li qalile ho hlakisa liphetoho tse ngata tse etsahalang bokong ka nako ena ea bophelo, le kamano ea bona le boits'oaro ba bongoana. Mothating ona, ho bonahala eka likarolo tse fapaneng tsa likarolo tse sa tsotelleng le tse nang le moputso seterekeng, tse amanang le libaka tse laoloang kamora nako moqoqong oa "cortex" ea pele, li ka lebisa ho liphetoho tsa boitšoaro tsa bongoaneng tse bonts'ang maikutlo a ntlafalitsoeng a kutloisiso ea tikoloho ntle le boits'oaro bo nepahetseng. thibelo. Phapang e ngata ea motho ka mong e boetse e bonahala e le bohlokoa bakeng sa ho bolela kotsi e kholo bakeng sa profil ena ea boits'oaro, e sa tsoa qala ho hlahlojoa ka matla. Lits'ebetso tse hloahloa tsa maikutlo le meputso tse tlohetsoeng ho sa laoloe ke litsamaiso tsa taolo ea pele e kanna ea ba "nebalance" ea bohlokoa e lebisang ho boitsoaro bo sa bonahaleng, bo ikhethang ba bocha. Re tšepa hore mosebetsi o tsoelang pele tšimong ena o tla ntlafatsa kutloisiso ea rona ea nako ena e khahlang le e rarahaneng ea bophelo.

lumela hore baa fokola

Mosebetsi ona o tšehelitsoe ke lithuso tsa NIH DA007274, 50-MH079513, R01 DA018879, R01 MH73175, lelapa la Mortimer D. Sackler, le Letlole la Dewitt-Wallace.

Mongolo o botlaaseng ba leqephe

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References

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