Neurotoxicol Teratol. Sengoloa se ngotsoeng; e fumaneha ho PMC 2009 September 1.
E hatisitsoe ka mokhoa o qetelle o hlophisitsoeng e le:
E hatisitsoe Inthaneteng 2008 April 22. doi: 10.1016 / j.ntt.2008.04.002
Moetso oa khatiso oa ho qetela oa mohatisi o fumaneha ho Neurotoxicol Teratol
Sheba lihlooho tse ling ho PMC hore Qotsa sehlooho se hatisitsoeng.
inahaneloang
Mekhoa ea neural e ikarabellang bakeng sa tlokotsi e ntlafatsang ea bosholu ba ho qala ts'ebeliso e mpe ea lithethefatsi ha e hlake. Re ile ra etsa lipatlisiso hore na phapang ea lilemo dopamine neurotransication e ka re hlalosetsa litlamorao tsa cocaine tse ntlafalitsoeng ka hara rat ea periadolescent. Ts'usumetso ea motlakase motlakase oa mesifa ea morao-rao ea matsatsi a 28 (PN28) le PN65 rats elicited dopamine ho nts'etsopele ea li-nucleus tsa caudate le nucleus accumbens mantlha pele le ka morao ho 15 mg / kg cocaine ip Extracellular dopamine concentrations ka PN65 ho feta PNNNNUMX ho latela PN28 ho PNXNPNNNXX 20 le 60Hz li-stimulus le li-nucleus tsa PN65 li bokellana ka mora ts'usumetso ea 60Hz. Cocaine e ile ea eketsa litefiso tsa dopamine tse khothalelitsoeng ke 20 Hz hlohlelletsa 3-fold ho motho e moholo, empa e batla e le 9-fold in periadolescent caudate. Sekhahla sa tokollo ea Dopamine se ne se le tlase ho periadolescent caudate le ha ho tlosoa ka botlalo ho dopamine ho ne ho tšoana le ha batho ba baholo. The periadolescent caudate e fihletse maemo a batho ba baholo ba tumello ka ho lefella V e tlase, max ka botsitso bo phahameng bo phahameng. Taolo e matla ea dopamine ea extracellular dopamine ka karolelano ea boemo bo phahameng ba ho phahamisa / ea ho lokolla periadolescents e lebisitse keketseho e kholo kamora cocaine. Ho li-nucleus accumbens, ho lokolloa ha dopamine le V, max li ne li le tlase ho periadolescents ho feta batho ba baholo, empa tšebelisano-'mōtoana e amanang le koae le eona e ne e tšoana. Ho se leka-lekane ha dopamine neurotransication ho dorsal striatum ho ka mpefatsa likarabo tse matla ho li-psychostimulants litekatsong tsa bocha 'me ho fana ka tlhahiso ea mokhoa oa ho beha kotsing ea batho ba lilemong tsa bocha bokhobeng ba lithethefatsi.
Keywords: Nts'etsopele, bokhoba, voltammetry, dopamine neurotransication, cocaine, bocha
khutsufalitsoeng
- PN
- post-natal (lilemo)
- [DA]p
- mahloriso a dopamine e lokollotsoeng ka matla a ho hlohlelletsa
- [DA], max
- kholo ka ho fetisisa evoke dopamine mahloriso
Mongolo o botlaaseng ba leqephe
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