J Neurophysiol. 2012 Sep;108(6):1620-30. doi: 10.1152/jn.00077.2012.
mohloli o moholo
Lefapha la Cellular le Molek'hule ea Molek'hule, Univesithi ea Rosalind Franklin, North Chicago, Illinois, USA. [imeile e sirelelitsoe]
inahaneloang
Nako ea bocha e ka ba nako ea ho lemalla lithethefatsi. Ho litoeba, mosebetsi o phahameng oa ho thunya oa "ventral tegmental area" (VTA) dopamine neurons o bolela esale pele molato o ntlafalitsoeng oa ho lemalla. Morero oa rona e ne e le ho bona hore na li-neurop tsa dopamine li mafolofolo ho feta lilemong tsa bocha ho feta ho batho ba baholo le ho hlahloba mekhoa e tlisoang ke phapang e amanang le lilemo. VTA dopamine neurons e ile ea fofa kapele ho bacha ho feta ho batho ba baholo joalo ka ha ho lekantsoe le liphatlalatsong tsa extracellular tsa vivo. Ho thunya ha neurop ea dopamine ho ka aroloa hore e be mese ea nonbursting (spikes e le 'ngoe) le tšebetso ea ho phatloha (lihlopha tsa li-spikes tse phahameng haholo. Ts'ebetso e seng ea nyatso e ne e phahame ho bacha ha e bapisoa le batho ba baholo. Liketsahalo tsa ho phatloha khafetsa li ne li sa fapana lipakeng tsa lilemo, empa ho phatloha ho ne ho le telele ho bacha ho feta ho batho ba baholo. Lenane le phahamisitsoeng la dopamine neuron le thunya ho litoeba tsa bocha le lona le ile la bonoa litlalehong tse kentsoeng ka seleng lisekeng tsa bongoaneng tsa v vivo. Re sebelisa lirekoto tse felletseng tsa lisele, re fumane hore thepa ea "membrane" e sebetsang le e sebetsang e ne e tšoana ho theosa le lilemo. Meetso ea li-cation tsa li-Hyperpolarization-activated cation le liteishene tse fokolang tsa calcium tsa matla a potasiamo le tsona li ka bapisoa ho theosa le lilemo. Ha rea fumana phapang ea ts'ebetso ea dopamine D2-class autoreceptor ho theosa le lilemo, le ha ho fokotseha hoa motheo ho bacha ho hlahisitse ts'ebetso ea autoreceptor e sa sebetse hantle ho khutsiseng li-neurons. Kamora nako, melapo ea "li-receptor-mediated spontaneous" e thabisang ea "li-circynaptic" tsa maqhubu e etsahetse maemong a tlase ho batjha; GABA (A) maqhubu a li-inhibitory-mediated spontaneous inhibitory postynaptic currents a etsahetse ka linako tse tlase le maemong a manyane ho banyane. Qetellong, VTA dopamine neurons e tuka ka potlako bocheng, ho ka etsahala hobane molumo oa GABA o eketseha ha likhoto li fihla ho batho ba baholo. Ho phahama hona ha sekhahla sa ho thunya nakong ea bocha ho tsamaisana le eona ho emela nako e tlokotsing ea ho theha lithethefatsi tsa lithethefatsi.
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