Neurotoxicol Teratol. 2019 Sep 7; 76: 106834. Doi: 10.1016 / j.ntt.2019.106834.
Dow-Edward D1, MacMaster FP2, Peterson BS3, Niesink R4, Andersen S5, Mabele BR6.
inahaneloang
Nako ea bocha ke nako ea ho hlophiseha ho hoholo hoa neural e etsang hore motho a be monyetleng oa ho ba kotsing le monyetla oa ho theha psychopathology. Ho hola ha lipotoloho tse fapaneng tsa methapo nakong ea bocha ho latela boholo ba boiphihlelo ba motho 'meleng le kelellong. Sena se etsahala ka ts'ebetso ea polasetiki eo e leng sebopeho sa tšebetso ea methapo ea kutlo ho arabela litlhoko tsa tikoloho, liphetoho tsa 'mele le boiphihlelo. Nakong ea bocha, tloaelo ena e fetela kamorao ho liphetoho tsa sebopeho le tšebetso tse hlahisitsoeng ke liphatsa tsa lefutso le li-epigenetic le liphihlelo tsa pele ho tsoalo le nakong ea pelehi. Plasticity e kenyelletsa phetoho ea likhokahano pakeng tsa li-neurons ka ho sebelisa bokhoni ba nako e telele (LTP) (e fetolang bokhoni ba synaptic), synaptogenesis, ho hlaha ha axonal, ho pheta-pheta dendritic, neurogeneis le ho hira (Skaper et al., 2017). Leha bopaki bo matla haholo ba tšebetso ea polasetiki bo tsoa lipatlisisong tsa methapo ea kutlo, liphuputso tsa morao tjena li bontšitse hore nakong ea bocha, maikutlo a sechaba, maikutlo le maikutlo li fetola sebopeho le tšebetso ea marangrang a fanang ka likarolo tsena tsa boits'oaro. E 'ngoe le e' ngoe ea likhokahano tsena tsa neural e bonts'a ts'oaetso ea ts'oaetso ea polasetiki e nang le boiphihlelo nakong ea linako tse mahlonoko tse etsahalang lipotolohong tse fapaneng le libakeng tse fapaneng tsa boko ka nako e itseng ea kholo. Tlaleho ena e tla akaretsa mehlala e meng ea boikoetliso bo etsahalang nakong ea bocha le bopaki bo bong ba hore boko ba bongoana bo arabela ka mokhoa o fapaneng ho susumetsa ha bo bapisoa le batho ba baholo le bana. Seboka sena sa puisano, "Boiphihlelo nakong ea bocha bo bopa kholo ea boko: ho tloha ho li-synapses le marang-rang ho ea ho boits'oaro bo tloaelehileng le ba mafu" e etsahetse nakong ea Kopano ea selemo le selemo ea Developmental Neurotoxicology Society / Teratology Society e Clearwater Florida, Phuptjane 2018. Likarolo li tla hlalosa ho butsoa ha boko nakong ea bocha joalo ka ha ho ithutiloe ka theknoloji ea ho nka litšoantšo, ho bontša kamoo polasetiki e bopang sebopeho sa boko ka ho sebelisa mehlala ea maemo a ts'oaetso joalo ka lefu la Tourette le lefu la tlhokomelo ea ho se tsotelle, le tlhahlobo ea litsamaiso tsa mantlha tsa limolek'hule ameha polasetiking ena le kamoo lintho tse ling tse atisang ho sebelisoa hampe li fetolang kholo ea boko. Karolo ea li-stimulants tse sebelisoang kalafo ea tlhokomelo e fokotsang hyperactivity disorder (ADHD) ka har'a polasetiki ea potoloho ea meputso e ea hlalosoa. Qetellong, tlhaiso-leseling ea kliniki e khothalletsang kutloisiso ea tšusumetso ea lithaka mabapi le boitšoaro bo kotsi ho bacha e fana ka bopaki ba ho rarahana ha mesebetsi eo lithaka li e etsang ho etsa liqeto, ketsahalo e fapaneng le eo ho motho e moholo. Liphuputso tse entsoeng ka boqhetseke li senotse hore ts'ebetso ea marang-rang ea marang-rang ke ho ba teng ha lithaka ka linako tse ling tsa ho etsa liqeto e ikhethile ho mocha. Kaha nts'etsopele e tloaelehileng ea boko e itšetleha ka boiphihlelo bo fetolang maqhama a sebetsang le a sebopeho lipakeng tsa lisele tse lipakeng tsa marang-rang le marang-rang ho fetola boitšoaro, babali ba ka tsebisoa ka mefuta e mengata ea mekhoa e tloaelehileng ea ntlafatso e ka utsuoang.
LINKOTSO: Kholiso ea boko ba bongoaneng; Likamano tsa kelello / Boitšoaro; MRI / fMRI; Plasticity
PMID: 31505230
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