Bokhoba ba Bacha: Cocaine le Nicotine li Matlafatsa Likamano tsa Dopamine Ho Boko ba Bacha, Kotsi e Eketsehang. phosphorylation ea eIF2α (2016)

Mar 1, 2016 Ka Stephanie Kossman

Lithethefatsi li ama boko ba bocha bo ntseng bo hola joang? Potso ena e makalitse bo-ramahlale ka mashome a lilemo, empa ntlha e le 'ngoe e ntse e le' nete - bacha ba kotsing ea ho lemalla joala. Hangata bo-rasaense ba e hlalositse maemong a sechaba, joalo ka khatello ea lithaka, kapa taba ea hore batsoali ba tsubang hangata ba khona ho tsosa bacha ba tsubang. Empa tse peli tse ncha lipampiri, hatisoa hammoho in Life, pheha khang ea hore lebaka le bile le tlhaho le ho feta.

Bo-rasaense ba kile ba sebelisa biology ho hlalosa bacha ba lemaletseng joala, empa ha e so sebelisoe joalo ka lebaka la ts'ebeliso e mpe ea lithethefatsi. "Ho batho, bocha, e leng nako e pakeng tsa lilemo tsa bocha le lilemo tse mashome a mabeli, ke nako ea ho ba le ts'oaetso e matla ea litlamorao tsa lithethefatsi tse lemalloang, empa lithuto tse fetileng li ile tsa sokola ho hlalosa hore na hobaneng," ho boletse mongoli e moholo Mauro Cosa-Mattioli, ho a tsebiso ea boralitaba. "Lithuto tsa rona li tšehetsa mohopolo oa hore taolo ea synthetiki ka eIF2 e kanna ea ba sesosa sa motheo."

Lithuto tse peli tse arohaneng li hlahlobile karolo ea elF2 α, molek'hule e laolang tlhahiso ea liprotheine tse ikarabellang bakeng sa khokahano lipakeng tsa li-neuron. Phuputsong e 'ngoe, litoeba tsa bocha le tsa batho ba baholo li ile tsa kenngoa ka tharollo ea saline kapa lethal dose e fokolang ea cocaine. Bafuputsi ba fumane feela litoeba tsa bocha tse fuoeng koae tse nang le phokotso ea ts'ebetso ea eIF2cy, e ileng ea fella ka liphetoho taolong ea protheine e matlafatsang khokahano lipakeng tsa methapo e tsamaisang dopamine.

"Puisano ena e kholo lipakeng tsa li-neurone tse nang le dopamine e fana ka maikutlo a monate ho feta ho sebelisa sethethefatsi mme e khothaletsa boits'oaro bo amanang le bokhoba," ho boletse mongoli ea etelletseng pele Wei Huang. “Ke tekanyetso e phahameng feela ea k'hok'heine e lebisitseng karabong e tšoanang ho litoeba tsa batho ba baholo, e leng se bontšang hore bacha ba na le moeli o fokolang oa liphello tsa k'hok'heine methapong ena.”

Bafuputsi ba ile ba boela ba khona ho netefatsa litholoana tsa bona ka ho fetola tlhahiso ea liprotheine tse laoloang ke eIF2cy ho litoeba tsa batho ba baholo le ba lilemong tsa bocha, ka tsela e nepahetseng ba etsa hore litoeba tsa batho ba baholo li bonahale ka tlhaho ea bongoana le litoeba tsa bongoaneng. Ka ho etsa joalo, bafuputsi ba bone liphetho tse fapaneng ho tloha karolong ea pejana ea thuto. Litoeba tsa lilemong tsa bocha, tseo hona joale li nang le likarolo tsa protheine ea batho ba baholo, ha lia ka tsa bontša phetoho mesebetsing ea elF2 α le ho hanyetsa ho eketsehileng ha koae. Limpho tsa batho ba baholo le tsona li ile tsa ameha haholoanyane.

“Ho a makatsa e le kannete hore ka ho qhekella lits'ebetso tse potileng eIF2cy ka tsela ena, re ka nchafatsa ts'ebetso ea boko. Sena se ka ba le ts'episo ea bohlokoa bakeng sa ho nts'etsapele kalafo tse ncha tsa bokhoba ba lithethefatsi le mathata a amanang le ona, "ho boletse Costa-Mattioli.

Phuputso ea bobeli e ngotsoeng pampiring e hlalositse liteko tse tšoanang, hammoho le nikotine ho fapana le koae. Hape, bafuputsi ba ile ba hlokomela litlamorao tse tšoanang. Re sebelisa monahano o sebetsang oa matla a phello ea matla, thuto e boetse e bontšitse phapang ea mofuta oa motho e bonts'ang li-eIF2cy. Ba fumane hore phapang ena e ka eketsa kapa ea fokotsa likarabo tsa basebelisi ba nicotine meputsong.

Mongoli ea etelletseng pele Andon Placzek o re: "Seo re se fumaneng se sebetsa hantle litleliniking kaha li supa sepheo sa ho lemalla litoeba litoeba, hammoho le bopaki bo tšoanang bo tšehetsang ho tsoa liphuputsong tsa ho nahana ka boko ho batho ba lemaletseng batho." Maikutlo a rona a macha a ka thusa ho ruta bacha ka likotsi tsa lithethefatsi tsa boithabiso. sebelisa le ho etsa liteko, ho nyahamisa boits'oaro bona ka lebaka leo. Ba ka thusa ho sibolla mokhoa o mocha oa ho loants'a bokhoba ho bacha le ho batho ba baholo, ka mohlala ka ho fetola tšebetso ea eIF2cy bokong. ”

Mohloli: Huang W, et al. Taolo ea phetolelo ea elF2 α phosphorylation e laola ho ba kotsing ea litlamorao tsa testaptic le boits'oaro ba koae. eLife. 2016; Placzek A, et al. Taolo ea phetolelo ea nicotine-evoke synaptic potentiation ho litoeba le likarabo tsa methapo ea kutlo ho batho ba tsubang ke elF2 α. eLife. 2016.

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