Physiol Behav. 2012 Jun 6; 106 (3): 332-6. doi: 10.1016 / j.physbeh.2012.03.020.
mohloli o moholo
Univesithi ea Florida, College of Medicine, Lefapha la Psychiatry, Mokhatlo oa Bokooa oa McKnight, Gainesville FL 32610, United States. [imeile e sirelelitsoe]
inahaneloang
Le ha li na le karolo e nyane feela ea methapo ea kutlo tikolohong eo, li-interneuron tsa cholinergic ka har'a dorsal striatum li bonahala li bapala karolo ea bohlokoa ho laoleng mekhoa e fapaneng ea boits'oaro, karolo e 'ngoe, ka ho sebelisana ha bona le litsamaiso tsa mesolimbic dopamine (DA). Tlhahlobisong ena, re hlalosa lithuto tse fanang ka maikutlo a hore ts'ebetso ea li-interneuron tsa cholinergic ho li-nucleus accumbens (NAc) le likhakanyo tsa cholinergic sebakeng sa ventral tegmental (VTA) li ama boits'oaro ba phepo. Liphuputsong tsa vivo microdialysis ho likhoto li senotse hore ho emisoa ha lijo ho amana le ho phahama ha maemo a acetylcholine (ACh) ho NAc. Ts'ebetso ea ACh e tla hatella phepo, 'me sena se boetse se amahanngoa le keketseho ea pokello ea synaptic ea ACh. Ho feta moo, re tšohla hore na, ntle le karolo ea bona pheletsong ea lijo, li-interneuron tsa cholinergic ho NAc li bapala karolo ea bohlokoa ho emiseng tšebeliso ea lithethefatsi. Sistimi e 'ngoe ea cholinergic e amehang likarolong tse fapaneng tsa boits'oaro ke ponelopele e tsoang ho nuclei ea pedunculpontine ka kotloloho ho VTA. Ts'ebetso ea sistimi ena e ntlafatsa boits'oaro ka ho kenya tšebetsong sistimi ea DA ea mesolimbic, mme ho hanyetsa li-receptor tsa ACh ho VTA ho ka fokotsa boits'oaro ba lithethefatsi. Kamora nako, re bua ka karolo ea ho bokella ACh ho tloheng ha lithethefatsi le tse khahlisang. Liphuputso li senola hore li-accumbens ACh lia eketseha nakong ea ho tlohela lithethefatsi tse fapaneng tsa tlhekefetso (ho kenyeletsoa cocaine, nicotine le morphine). Ho phahama hona ha maemo a kantle ho lisele tsa ACh, hammoho le ho fokotseha ha maemo a kantle ho lisele tsa DA, ho lumeloa hore ho tlatsetsa ho boemo bo fetohelang, bo ka bonts'ang e le boits'oaro bo amanang le ho tlohela lithethefatsi. Khopolo ena e boetse e sebelisitsoe lipatlisisong tsa ho ja ho tlōla le / kapa "ho lemalla lijo," mme liphetho li fana ka maikutlo a ho se leka-lekane ho ts'oanang maemong a DA / ACh, a amanang le boits'oaro ba boits'oaro bo joalo ka lithethefatsi. Ka kakaretso, li-neuron tsa cholinergic li bapala karolo ea bohlokoa ho fetoheng ha lijo le lithethefatsi, hammoho le likarolo tse fapaneng tsa boitšoaro le lithethefatsi tse amanang le lithethefatsi.
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