Liphetoho tsa liphatsa tsa lefutso ka hare ho nucleus accumbens le striatum ka mor'a phihlelo ea thobalano (2005)

Genese Brain Behav. 2005 Feb;4(1):31-44.

Bradley KC, Boulware MB, Jiang H, Doerge RW, Meisel RL, Mermelstein PG.

mohloli o moholo

Lefapha la Neuroscience, Univesithi ea Minnesota, Minneapolis, MN 55455, USA.

inahaneloang

Boiphihlelo ba thobalano, joalo ka tšebeliso ea lithethefatsi khafetsa, bo hlahisa liphetoho tsa nako e telele ho kenyelletsa sensitization ho li-nucleus bokellanang le dorsal striatum. Ho utloisisa hamolemo mekhoa ea limolek'hule e neng e theha maqhubu a morao ho thobalano, re sebelisitse mokhoa oa DNA oa ho khetholla liphatsa tse fapaneng tse hlalositsoeng lipakeng tsa li-hamsters tsa basali ba nang le thobalano le bootsoa kahare ho li-nucleus tse bokellaneng le dorsal striatum. Bakeng sa libeke tsa 6, e tona e ts'oeroeng e ne e beoa terakeng ea lapeng ea halofo e le 'ngoe ea li-hamsters tsa basali tse emisitsoeng. Bekeng ea bosupa, lihlopha tse peli tsa liteko li ile tsa aroloa, 'me halofo e le' ngoe e ne e pentiloe le e tona e ntšusumetsang. Ha ho bapisoa le liphoofolo tse tsosang takatso ea botona le botšehali, li-hamsters tse nang le tsebo ea thobalano tse amohelang e motona ka beke 7 li bonts'itse keketseho ea palo e kholo ea mefuta. Ka lehlakoreng le leng, li-hamsters tsa basali tse nang le thobalano tse sa amohelang monna ea tsosang ka beke ea 7 li bontšitse phokotso polelo ea mefuta e mengata.

Bakeng sa liphetoho tse tataisang le mefuta ea liphatsa tsa lefutso tse laoloang ke maemo a liteko, datha li ne li ts'oana ho potoloha li-nucleus accumbens le dorsal striatum. Leha ho le joalo, mefuta e khethehileng e bonts'ang liphetoho lipuong e ne e sa fapana. Liteko tsena, har'a tsa pele tsa ho hlahisa mofuta o laoloang ke boitšoaro ba basali ba thobalano, li tla fana ka leseli ho mekhoa eo ka eona boits'oaro le lithethefatsi tsa tlhekefetso li susumetsang liphetoho tsa nako e telele litseleng tsa mesolimbic le nigrostriatal dopamine.