Genese Brain Behav. 2013 Jun 22. Doi: 10.1111 / gbb.12060.
E bile LE, Hedges VL, Vialou V, Nestler EJ, Meisel RL.
mohloli o moholo
Univesithi ea Minnesota, Lefapha la Neuroscience, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN, 55455, USA.
inahaneloang
Boitšoaro bo susumetsoang, bo kenyeletsang boiphihlelo ba botona le botšehali, bo kenya tšebetsong sistamine ea mesolimbic le ho hlahisa liphetoho tse tšoarellang molek'hule le sebopeho ka har'a li-nucleus accumbens. Ntlha ea phetisetso ΔFosB e hokahantsoe ho arola likarolo tsa polasetiki ena tse itšetlehileng ka boiphihlelo.
Patlisiso e fetileng ka laboratoring ea rona e bonts'itse hore ΔFosB e matlafatsang ho bokaholimo ba nyutlelie ea basali ba basali ba maSyria augges bokhoni ba boiphihlelo ba thobalano bo ka etsa hore ho be le thatohatsi ea sebaka. Ha ho tsejoe, leha ho le joalo, hore na transcript ea ΔFosB-mediated ho li-bokellase tsa nucleus e hlokahala bakeng sa litlamorao tsa boits'oaro ba moputso oa thobalano.
Ka hona re sebelisitse vaerase e amanang le adeno ho overexpress ΔJunD, molekane ea matla ea tlamang oa ΔFosB ea fokotsang phetisetso ea ΔFosB e kopantsoeng le tlholisano ea heterodimerizing le ΔFosB pele a tlama libakeng tsa papatso ka mefuta ea sepheo, bokong ba li-nucleus.
Re fumane hore overexpression ea ΔJunD e thibetse ho etsoa ha sebaka se khethiloeng ka mor'a liphihlelo tsa khafetsa tsa thobalano. Litlaleho tsena, ha li kopane le liphuputso tsa rona tsa pele, li fana ka maikutlo a hore ΔFosB e hlokahalang ebile e lekane bakeng sa polasetiki ea boitšoaro ka mor'a phihlelo ea thobalano. Ho phaella moo, liphello tsena li tlatsetsa ho lingoliloeng tsa bohlokoa le tse ntseng li hōla tse bontšang tlhokahalo ea maikutlo a fokolang a ΔFosB a nucleus accumbens bakeng sa ho ikamahanya le maemo ho itšetlehile ka tšusumetso e ntle ea tlhaho.
Sengoliloeng sena se sirelelitsoe ka molao oa bongoli. Litokelo tsohle li sirelelitsoe.
;