Nucleus accumbens NMDA e amohelang matla a ho laola li-amphetamine ho etsa hore batho ba khone ho tšoaea sefahleho le marulelo a fapaneng .FosB e bua ka phihlelo ea ho kopanela liphate ka likhoto tsa banna (2015)

2015 Sep 21;101:154-164. doi: 10.1016/j.neuropharm.2015.09.023.

Belo LN1, Mofuta oa PW1, Casey GR2, Webb IC2, Coolen LM3.

inahaneloang

Boiphihlelo ba botona le botšehali ho likhoto tsa banna tse lateloang ke nako ea ho itlopa joala bo baka tšusumetso ho moputso oa d-Amphetamine (Amph), o pakahatsoa ke khetho e atolositsoeng ea sebaka (CPP) bakeng sa tekanyetso e tlase ea Amph. Ntle le moo, boiphihlelo ba thobalano bo etsa hore ho be le polasetiki ea neural ka hare ho nucleus accumbens (NAc), ho kenyelletsoa ho kenella ho deltaFosB, e phethang karolo ea bohlokoa phihlelong ea kutlo ea moputso oa Amph.

NMDA receptor subunit NR1 e boetse e ntlafalitsoe ke ho ruruha, empa bohlokoa ba tšebetso ea li-receptor tsa NMDA litlamorao tsa ts'usumetso ea thobalano ha li tsejoe.

Mona, re hlahlobe tšusumetso ea infusions-NAc MK 801 infusions mabapi le boiphihlelo ba botona ba botona le botšehali ba NAc deltaFosB le polelo ea cFos, hammoho le ho nyalanya- le Amph-indised CPP litlamong tsa banna ba baholo.

Ho leka 1, banna ba ile ba fumana MK 801 kapa saline ho NAc nakong e ngoe le e ngoe ea matsatsi a 4 a latellanang a ho ts'oaroa kapa ho sebetsana mme ba ile ba lekoa bakeng sa Amph CPP le boiphihlelo ba deltaFosB 10 kamora moo.

Intra-NAc MK 801 nakong ea boitšoaro ba thobalano e thibetse keketseho ea boiphihlelo ho Amph CPP le polelo ea NAc deltaFosB ntle le ho ama boits'oaro.

Ho teko ea 2, litlamorao tsa intra-NAc MK 801 ho CPP e kenyellelitsoeng ho popelong li ile tsa hlahlojoa ke infra-NAc infusions ea MK 801 kapa saline pele ho mating ka matsatsi a maemo. Intra-NAc MK 801 ha e-ea ama CPP e kenyellelitseng botsitso.

Ka mor'a moo, ho ile ha hlahlojoa litla-morao tsa intra-NAc MK 801 mabapi le ho itšireletsa ka tšireletso ea cFos. MK 801 e thibetse polelo ea cFos ea ho kopanya le ho qaptjoa ha NAC khubung le mokokotlong.

Ka bobeli, liphetho tsena li fana ka bopaki ba hore ts'ebetso ea receptor ea NAc NMDA nakong ea boitšoaro ba thobalano e bapala karolo ea bohlokoa ho kopantseng tlhoko ea cFos le polelo ea deltaFosB le boiphihlelo bo latelang bo susumetsang tšusumetso ea sefofane sa Amph.