Tlhahlobo ea thobalano e fetola tlhahiso ea AMP ea mokelikeli oa motlakase oa D1 mokokotlong oa hamster ea Basyria (2004)

Synapse. 2004 Jul;53(1):20-7.

Bradley KC1, Mullins AJ, Meisel RL, Watts VJ.

inahaneloang

Lithethefatsi tsa tlhekefetso li hlahisa liphetoho tsa nako e telele ho dopamine neurotransication le ho ts'oaroa ha li-intracellular signaling. Liphetoho tse tšoanang ho ts'ebetso ea neuronal li kopantsoe le boitšoaro bo susumetsang. Ho hlahloba mekhoa ea methapo ea kutlo e ka tlase ho li-neuroadaptations tsena tse latelang boiphihlelo ba botona le botšehali, ho bokelloa ha cyclic AMP kamora ho hlohlelletsa D1 dopamine receptors, G-protein, le adenylate cyclase ho ile ha bapisoa le li-nucleus tsa li-nucleus le li-nucleus tsa caudate tsa hamsters tsa basali tse se nang tsebo le tse latelang tsa boitšoaro ba thobalano. Ho hlohlelletsa ka kotlolloho cyclase ea adenylate ka forskolin kapa ka tsela e sa tobang ka ts'ebetso ea liprotheine tsa G-GPp (NH) p e hlahisitse keketseho e thehiloeng ho litekanyetso ho theheng ha cyclic AMP ho li-nucleus tsa li-nucleus le li-nucleus tsa caudate, ntle le litlamorao tsa boiphihlelo ba thobalano ka mehato ena. Ketsahalo e ikhethileng ea D1 receptor e eketsang ts'ebetso ea Gpp (NH) p-e khothalletsang adenylate cyclase ts'ebetsong ea li-nucleus accumbens le caudate nucleus ea liphoofolo tsohle. Ho khahlisang, ts'usumetso ena e ile ea matlafatsoa le ho feta feela ka likarolo tse tsoang li-bokong tsa li-nucleus, empa eseng ho tsoa ho caudate nucleus, ea li-hamsters tse nang le boiphihlelo ka thobalano ha li bapisoa le karabelo ea basali ba sa tsebeng letho. Liphetho tsena li bonts'a hore boiphihlelo ba thobalano bo ka nolofatsa mesolimbic dopamine pathways le hore maikutlo ana a hlaha ka keketseho ea ho saena hoa D1 receptor-mediated.