Funct ea lijo. 2019 Apr 17;10(4):1985-1998. doi: 10.1039/c8fo02118j.
Reichelt AC 1, Gibson GD , Abbott KN , Hare DJ .
inahaneloang
Polasetiki ea boko ke ts'ebetso e nang le likarolo tse ngata e ipapisitseng le li-neurons le li-extracellular matrix (ECM), ho kenyeletsoa le matlooa a perineuronal (PNNs). Ka har'a medial prefrontal cortex (mPFC) li-PNN li potile haholo-holo li-parvalbumin (PV) tse nang le li-interneuron tsa GABAergic mme li bohareng ba taolo ea methapo ea pelo. Ntle le nts'etsopele ea botena, lijo tse nang le mafura a mangata le tsoekere e ngata (HFHS) le tsona li amahanngoa le liphetoho lipolotiking tsa boko le boits'oaro ba maikutlo ho batho. Ho lekola ho ameha ha mantlha ha li-PNN le polasetiki ea cortical ho mPFC mokhoeng oa boitšoaro bo tlositsoeng ke boitšoaro (ntlheng ena ho tsebahala ka sechaba), re pepesitse likhoto tsa bocha (matsatsi a kamora ho hlaha P28-P56) ho lijo tse tlatselitsoeng ke HFHS. Ho liphoofolo tse fepehileng tsa P56 HFHS le lits'oants'o tse lumellanang le lilemo li fuoe li-chow tse tloaelehileng li ile tsa matlafatsoa le ho sebelisana le libaka tsa li-PNN le li-PV neurons ho prelimbic (PrL) le infralimbic (IL) le libaka tsa anterior cingulate (ACC) tsa PFC li ile tsa hlahlojoa ke fluorescence e habeli ea immunohistochemistry. Polelo ea osBFosB e ile ea hlahlojoa hape e le tekanyo ea ts'ebetso e sa foleng le boits'oaro ba ho lemalla boitšoaro. Ts'ebeliso ea lijo tsa HFHS e fokolitse palo ea li-neuron tsa PV + le li-PNN sebakeng sa infralimbic (IL) sa mPFC ka -21.9% le -16.5%, ka ho latellana. Le ha li-neuron tsa PV + le li-PNN li ne li sa fokotsehe haholo ho ACC kapa PrL, liperesente tsa PV + le PNN tse hlalosang li-neuron li ile tsa eketsoa libakeng tsohle tse lekiloeng tsa mPFC ho likhoto tse fepetsoeng ke HFHS (+ 33.7% ho + 41.3%). Sena se bontša hore palo ea li-neuron tsa PV tse setseng ke tse lika-likelitsoeng ke li-PNN, tse ka fanang ka ts'ireletso khahlano le mFFC-dysregulation e bakoang ke ho ja ea HFHS. Polelo ea osBFosB e bonts'itse keketseho ea makhetlo a 5-10 (p <0.001) sebakeng se seng le se seng sa mPFC, e ts'ehetsa khopolo-taba ea hore phepo ea HFHS e baka ho se sebetse ha mPFC le likhaello tsa boitšoaro tse latelang. Lintlha tse hlahisitsoeng li bonts'a mochini o ka bang le ts'ebeliso ea methapo ea pelo le karabelo ho likhaello tse ikhethileng tsa phepelo ea sechaba ka lebaka la phepelo ea hypercaloric bocheng.
PMID: 30900711
DOI: 10.1039 / c8fo02118j
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