Funct ea lijo. 2019 Apr 17;10(4):1985-1998. doi: 10.1039/c8fo02118j.
Reichelt AC 1, Gibson GD , Abbott KN , Hare DJ .
inahaneloang
Brain plasticity ke ts'ebetso e kopaneng e itšetlehileng ka li-neurons le li-extracellular matrix (ECM), ho kenyelletsa le li -ineine tsa perineuronal (PNNs). Ka medial prefrontal cortex (mPFC) PNNs haholo li pota-potile ka potlako li-spiking parvalbumin (PV) - li-interneurons tsa GABAergic 'me li bohareng ba taolo ea methapo ea kutlo. Ntle le nts'etsopele ea botenya, lijo tse nang le mafura a mangata le tsoekere e ngata (HFHS) li boetse li amahanngoa le liphetoho lipakeng tsa bongoana le boits'oaro ba maikutlo ho batho. Ho hlahloba ho kenella ha PNNs le ho hlonama ka polasetiki ho mPFC khafatsong ea boiketlo ba boits'oaro (tabeng ena ho amoheloa sechabeng), re senoletse likhoto tsa bongoaneng (matsatsi a ho beleha P28-P56) ho lijo tse tlatselitsoeng ke HFHS. Sebakeng sa P56 HFHS liphoofolo tse fepehileng le li-control tse tsamaeang le lilemo li filoe maemo a tloaelehileng li ile tsa khothaletsoa le ho kopanngoa ha li-PNN tse nang le li-neurons tsa PV sebakeng sa prelimbic (PrL) le infralimbic (IL) le anterior cingulate (ACC) libaka tse tlase tsa PFC li hlahlobiloe ke habeli fluorescence immunohistochemistry. Polelo ea ΔFosB e boetse ea hlahlojoa e le mokhoa oa ho ikoetlisa ho sa feleng le boits'oaro ba boits'oaro. Tšebeliso ea lijo tsa HFHS e fokolitse palo ea li-neuron tsa PV + le li-PNN sebakeng sa infralimbic (IL) sa mPFC ka -21.9% le -16.5%, ka ho latellana. Le ha li-neurons tsa PV + le PNN li ne li sa fokotsehe haholo ho ACC kapa PrL, liperesente tsa PV + le PNN tse buang ka tšohanyetso li ile tsa eketseha libakeng tsohle tse lekiloeng tsa MPFC ho likhakanyo tsa phepo ea HFHS (+ 33.7% ho + 41.3%. Sena se bontša hore palo ea li-neurons tsa PV tse setseng ke tse pota-potiloeng ke li-PNN, tse ka fanang ka tšireletso e itseng khahlano le HFHS mysF-dysregulation. Polelo ea osBFosB e bontšitse keketseho ea makhetlo a 5-10 (p <0.001) sebakeng se seng le se seng sa mPFC, e ts'ehetsa khopolo-taba ea hore phepo ea HFHS e baka ho se sebetse ha mPFC le likhaello tse latelang tsa boitšoaro. Lintlha tse hlahisitsoeng li bonts'a mochini o ka bang le ts'ebeliso ea methapo ea pelo le karabelo ho likhaello tse ikhethileng tsa phepelo ea sechaba ka lebaka la phepelo ea hypercaloric bochenge.
PMID: 30900711
DOI: 10.1039 / c8fo02118j
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