Ho Kopana pakeng tsa Phatlalatso ea Amphotamine-Boikemisetso ba ho Ikamahanya le Boits'oaro le Cdk5 / p35 Mosebetsi ho Dorsal Striatum (2015)

Behav Neurosci. 2015 Dec 21.

Mlewski EC, Arias C, Paglini G.

inahaneloang

Sensitization ho psychostimulants e susumetsoa ka matla ke tikoloho eo ho eona ho sebelisoang moriana 'me ha ho tsejoe hanyane ka mochine oa limolek'hule o laolang tšebetso ena. Phekolo e sa foleng le li-psychostimulants e bontšitsoe ho nyolla polelo ea cyclin-wate kinase 5 (Cdk5) ho striatum, e le mofuta o tlase oa sepheo sa ΔFosB. Phuputso ena e entsoe ka mokhoa oa ho sekaseka liphetoho tsa methapo e meng e hlahisang maikutlo a tlhaselo ea amphetamine. Ho fihlela sena, likhoto tsa periadolescent li ile tsa fuoa saline kapa 4 mg / kg amphetamine tikolohong ea NOVEL kapa HOME. Kamora letsatsi la 1, lithuto li ile tsa phephetsoa ka koloi kapa 2 mg / kg amphetamine maemong a ts'oanang moo ba amohetseng taolo ea pele ea moriana. Ketsahalo ea locomotor le maemo a polelo a p35 le Cdk5 tšebetso ea li-synaptosomes tsa dorsal striatum li ile tsa hlahlojoa.

Polelo ea boitšisinyo ba boitšoaro e bonoe feela maemong a NOVEL. Ho feta moo, ke liphoofolo feela tse koetlisitsoeng le tse lekiloeng maemong a NOVEL tse bonts'itseng litekanyetso tsa protheine ea p35 le ts'ebetso ea Cdk5. Liphumano tsa rona li fana ka bopaki bo hlakileng ba boits'oaro le li-neurochemical tsa kopano e ikhethang pakeng tsa ts'ebetso e eketsehang ea p35 le Cdk5 ho dorsal striatum le polelo ea maikutlo a amphetamine-boitšoaro, ho re lumella ho fana ka tlhahiso ea p35 e le letšoao la biochemical la boits'oaro. sensitization to amphetamine.