Neuropsychopharmacology. 2013 May 21. Doi: 10.1038 / npp.2013.130.
Wang J, Fanous S, Terwilliger EF, Bass CE, Hammer RP Jr, Nikulina EM.
mohloli o moholo
1] Lefapha la Saense ea Motheo oa Bongaka, Univesithi ea Arizona College of Medicine, Phoenix, AZ, USA [2] Lenaneo la Neuroscience, Univesithi ea Arizona State, Tempe, AZ, USA.
inahaneloang
Matšoenyeho a taolo ea sechaba a etsa hore maikutlo a phehelle-khahlano ho li-psychostimulants, empa lits'ebetso tsa limolek'hule tse nts'etsopele ea maikutlo a sefapano li lula li sa hlaka. Motho a le mong ke neurotrophic factor (BDNF). Patlisiso e teng e bonehetse hore na sebaka sa phetoho ea moea o mongata (VTA) BDNF se ka eketsang nako ea maikutlo ka mor'a khatello e le 'ngoe ea khatello ea sechaba, eo hangata e hlahisang maikutlo a nakoana a sa feteng beke e le' ngoe.
ΔFosB, letšoao la limolek'hule tsa lemalla ntho, e ne e boetse e lekantsoe libakeng tsa mesifa ea mesocorticolimbic.
Lihlopha tse ikhethileng tsa likhoto tsa banna tse sa sebetseng tsa Sprague-Dawley li bile le ketsahalo e le 'ngoe ea khatello ea maikutlo ea taolo kapa ho sebetsana ka katleho, e lateloang ke phephetso ea XiUMX kapa 3 matsatsi hamorao. AMPH-sensitization ea sefapano e ne e bonahala ka 14 empa eseng matsatsi a 3 kamora khatello ea maikutlo. Ho kenella ka hare ho intra-VTA ea vector e amanang le vaerase (AAV-BDNF) ho bakile keketseho e habeli ea boemo ba BDNF ha e bapisoa le sehlopha se fumanang vaerase ea taolo (AAV-GFP), e nkile matsatsi a 14 bonyane.
Ntle le moo, ho hlahisoa ha BDNF ho VTA feela ho ekelitse ΔFosB ho li-nucleus accumbens (NAc) le cortex ea pele.
Matsatsi a leshome le metso e mene ka mor'a ts'oaetso ea vaerase, sehlopha se ikemetseng sa litoeba se ile sa hatelloa kapa sa sebetsana le ho ts'oaroa mme sa qholotsoa ka matsatsi a mane amphetamine (AMPH) 14 le 24 kamora khatello ea maikutlo. Likhoto tsa AAV-BDNF tse pepesitsoeng khatello ea kelello li bontšitse tšusumetso e telele ea sefapano mme e nolofalletsa maikutlo ho phephetso ea bobeli ea lithethefatsi. Immunohistochemistry e bonts'itse hore cHo kopana ha VTA BDNF e ntlafalitsoeng ka bongata, khatello ea maikutlo le AMPH li hlahisitse keketseho ea ΔFosB khetla ea NAc ha e bapisoa le lihlopha tse ling. Kahoo, ho phahamisoa ha VTA BDNF ho holisa tšusumetso ea maikutlo, ho nolofatsa maikutlo, le ho eketsa ΔFosB libakeng tsa mesocorticolimbic terminal. Kahoo, VTA BDNF e phahameng e ka ba sesosa sa kotsi ea kutloisiso ea lithethefatsi.
Neuropsychopharmacology e amohetse tlhahlobo ea pele ea sehlooho inthaneteng, 21 May 2013; Doi: 10.1038 / npp.2013.130.
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