J Neurosci. 2018 Jun 27;38(26):5913-5924. doi: 10.1523/JNEUROSCI.0296-18.2018
Aleyasin H1, Flanigan ME1, Golden SA2, Takahashi A1,3, Menard C1,4, Pfau ML1, Multer J1, Pina J1, McCabe KA5, Bhatti N1, HOD GE6, Heshmati M1, RL Rate7, Nestler EJ1, Heller EA8, Russo SJ9.
inahaneloang
Palo e ntseng e hola ea lithuto e kenyelletsa meputso ea boko ka boits'oaro bo mabifi. Leha ho le joalo, mechini ea lisele le limolek'hule tse kahare ho libaka tsa meputso ea boko tse fokotsang matla a mabifi hammoho le tšusumetso ea tsona ha lia nkuoa. Mona, re batlisisa tšusumetso e ikhethileng ea mofuta oa sele ea ΔFosB, sengoloa sa sengoloa se tsejoang ho laola meputso e mengata le boits'oaro bo susumetsang, bo sebetsang ho nucleus accumbens (NAc), sebaka se ka sehloohong sa moputso, ho mabifi a banna litoeba. Re bontša hore ΔFosB e eketsehile ka ho khetheha ho dopamine D1 receptor (Drd1) -e hlahisa li-spiny neurons tse mahareng (D1-MSNs) ho NAc kamora ho kopana khafetsa. Ho kenella ka bongata ha ΔFosB ka mokhoa o ikhethileng ho D1-MSNs ea NAc ho matlafatsa boits'oaro ntle le ho ama khetho ea moelelo o patiloeng ka mabifi sebakeng sa maemo a khethiloeng (CPP). Ka lehlakoreng le leng, ΔFosB e kenella ka har'a D2-MSNs e fokotsa nako e sebelisitsoeng ho lekola moelelo o mabifi nakong ea CPP ntle le ho ama matla a mabifi ka bonngoe. Lintlha tsena li tšehetsa ka matla karolo e ikhethileng ea mofuta oa sele bakeng sa ΔFosB ho NAc ho hlophiseng moputso oa pefo le pefo.TLHOKOMELISO SIGNIFICANCE Boitšoaro bo bohloko bo amahanngoa le mathata a mangata a amanang le neuropsychiatric mme a ka ferekanya batho ba amehileng hammoho le bahlaseluoa ba bona. Boithuto bo bontšitse mokhoa o nepahetseng oa ho matlafatsa o tlasa boitšoaro bo mabifi bo arolelanang likarolo tse ngata tse tloaelehileng le bokhoba ba lithethefatsi. Mona, re hlahloba karolo e ikhethileng ea karolo ea selefouno e amanang le tšusumetso e amanang le temallo. Re fumane hore polelo ea ΔFosB e khothalletsa boitšoaro bo mabifi, litlamorao tse sa amaneng le litlamorao tsa moputso oa bompoli. Ho fumana hona ke mohato oa pele oa bohlokoa ho khetholla lipheo tsa kalafo bakeng sa phokotso ea boits'oaro bo mabifi ho pholletsa le mafu a mangata a amanang le neuropsychiatric.
LINKOTSO: mabifi; mofuta oa sele e itseng; tšusumetso; li-nucleus accumbens; ΔFosB
PMID: 29891732
PMCID: PMC6021989
DOI: 10.1523 / JNEUROSCI.0296-18.2018
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