J Psychopharmacol. 2016 Mots'eanong 4. pii: 0269881116645300.
Mosebetsi oa Buenrostro-Jáuregui M1, Ciudad-Roberts A.2, Moreno J2, Munoz-Villegas P2, López-Arnau R2, Ho phatlalatsa D2, Escubedo E3, Camarasa J2.
inahaneloang
Methylenedioxypyrovalerone (MDPV) ke cathinone ea maiketsetso e sa tsoa hlaha e le sethethefatsi sa tlhekefetso. Morero oa thuto ena e ne e le ho etsa lipatlisiso tse mabapi le maikutlo a locomotor a hlohlellelitsoeng ke MDPV ho litoeba tsa bocha, le liphetoho tse amanang le neuroplastic bokong ba li-nucleus le striatum ka polelo ea deltaFosB le CREB. Teko ea boits'oaro e ne e na le mekhahlelo e meraro: Karolo ea 1: regimen ea maemo le MDPV (0.3 mg / kg / letsatsi bakeng sa matsatsi a mahlano) kapa saline; Phase ea II: ho phomola (matsatsi a 11); Phase III: phephetso le MDPV (0.3 mg / kg), cocaine (10 mg / kg) kapa letsoai ka letsatsi 16 bakeng sa lihlopha tsena ka bobeli. Litlatsetso li pepesitsoe khafetsa MDPV e eketsang ts'ebetso ea locomotor ka 165-200% kamora MDPV e mpe kapa tsamaiso ea koae ka mor'a nako ea phomolo ea matsatsi a 11, e bonts'ang maikutlo a ho susumetsa a MDPV ka boeona le ho cocaine. Tlhaloso bakeng sa ketsahalo ena e kanna ea ba mokhoa o tloaelehileng oa ts'ebetso lipakeng tsa li-psychostimulants tsena tse peli. Ntle le moo, phephetso ea MDPV e hlahisitse maemo a holimo a litoeba tse maemong a MDPV ha li bapisoa le litoeba tsa MDPV-naive, mohlomong ka lebaka la taolo ea tsela ea cAMP. Ka mokhoa o ts'oanang, ho pepesetsoa hoa MDPV ho bakile keketseho e phehellang polelo ea striatal ea deltaFosB; tekanyetso ea pele ea MDPV le eona e hlahisitse keketseho e kholo ponts'ong ea tlatsetso ea ntho ena e ngotsoeng. Boithuto bona ke bopaki ba pele ba hore ho pepesetsoa lethalinyana le tlase la MDPV nakong ea bohlankana ho etsa hore motho a be le boits'oaro 'me ho fana ka motheo oa neurobiological bakeng sa kamano lipakeng tsa MDPV le cocaine. Re kholoa hore, e ts'oanang le cocaine, CREB le deltaFosB li bapala karolo ea bohlokoa ba maikutlo a boitšoaro.
LINKOTSO:
CREB; MDPV; koae; deltaFosB; tlhokomeliso
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