Am J Drug Alcohol Abuse. 2019;45(3):264-275. doi: 10.1080/00952990.2019.1569667.
Mohloli T1, Le Sueur-Maluf L1, Prearo L2, Conte R3, Viana MB1, Ho fetisoa IC4.
inahaneloang
LITLHAHISO:
Karolo ea libaka tse ikhethileng tsa likhoerekhoere tse amehang bothateng ba tšebeliso ea lino tse tahang, joalo ka amygdala, hippocampus le preortalal cortex, e hlahile e le taba e khahlang lilemong tsa morao tjena. Leha ho le joalo, karolo e bapaloang ke libaka tsena hangata e ferekanngoa ke mefuta e fapaneng, har'a tsona ke mekhoa ea joala e hlahisitsoeng ke lihlooho.
LIPOTSO:
Phuputso e teng hona joale e netefalitse litlamorao tsa ho ja ho sa feleng tsa ethanol (litekanyetso tse 20) ho ts'ebeliso ea 'mele ea DeltaFosB (DeltaFosB-ir) ho amygdala, hippocampus le preortalal cortex ea likhoto tse bonts'a khetho e phahameng le e tlase ea ethanol.
LITLHAHISO:
DeltaFosB-ir e hlohlellelitsoe ke ts'ebeliso e sa foleng ea ethanol e nang le phihlello ea libotlolo tse peli ea mofuta oa 20% oa ethanol ho likhoto tsa banna tsa Wistar e lekantsoe. Ho ile ha hlahlojoa lihlopha tse tharo tsa liphoofolo: taolo (n = 6), khetho e tlase (n = 8) le khetho e phahameng (n = 8) bakeng sa ethanol, tse peli tsa morao-rao li arotsoe ka mokhoa oa tsona oa tšebeliso ea boithatelo ea tharollo ea joala.
LIKOTSO:
Ho ja ka mokhoa oa Ethanol maemong a holimo ho likhoto ho ile ha eketsa DeltaFosB-ir karolong e bohareng ea amygdala, CA1 le CA3 libakeng tsa hippocampus mme ea fokotsa DeltaFosB-ir sebakeng sa prelimbic cortex le anterior cingrate cortex. Ka lehlakoreng le leng, lithetleng tse tlase tse sa rateheng, ho ja ho sa feleng tsa ethanol ho fokotsehile DeltaFosB-ir ho amygdala ea medial, basolateral amygdala, gyrus ea meno le anterior cingates cortex.
CONCLUSIONS:
Liphetho tse teng hona joale li fana ka maikutlo a hore mekhoa e fapaneng ea tšebeliso ea joala e amana le sebopeho se ikhethileng sa DeltaFosB-ir likarolong tsa boko tse etsang karolo ea bohlokoa taolong ea boitšoaro le ho etsa liqeto, e leng amygdala, hippocampus le preortalal cortex.
LINKOTSO: Bothata ba tšebeliso ea joala; DelunFosB immunoreactivity; amygdala; tsamaiso e sa khaotseng ea ethanol; hippocampus; preortal cortex
PMID: 30849242
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