Neuropharmacology. 2014 Feb; 77: 224-33. Doi: 10.1016 / j.neuropharm.2013.09.019.
Lazenka MF1, Selley DE1, Sim-Selley LJ2.
inahaneloang
Tsamaiso e phetoang ea Δ (9) -tetrahydrocannabinol (THC) e hlahisa boikemelo le ho theoha hoa mofuta oa li-cannabinoid mofuta oa li-1 receptors (CB₁Rs) bokong, empa boholo ba liphetoho tsena lia fapana har'a libaka. Li-CB₁R literekeng le litlamong tsa eona li hlahisa boholo bo tlase le nts'etsopele e potlakileng ea ho ikemisetsa le ho theola melao. Mekhoa ea limolek'hule e fanang ka phapang ena e itšetlehileng ka libaka ha e tsejoe. Ntho e tsitsitseng ea ho ngoloa, osFosB, e kenngoa tšebetsong ka mor'a ts'ebetso e pheta-phetoang ea THC mme e ka tsamaisa li-CB₁R. Ho bapisa ka kotloloho boemo ba tikoloho ea ΔFosB induction le ho nyahama ha CB₁R le ho theoha hoa litheko, litoeba li ile tsa tšoaroa ke THC (10 mg / kg) kapa koloi bakeng sa matsatsi a 13.5. CP55,940-stimated [(35) S] GTPγS autoradiography and immunohistochemistry li ile tsa etsoa ho lekanya boikemisetso ba CB₁R le ho theoha ha maemo, ka ho latellana, 'me polelo ea ΔFosB e lekantsoe ke immunoblot. Boikemisetso ba CB₁R ba bohlokoa le ho fokotseha hoa eona ho etsahetse ka kotloloho ea pele, amygdala ea morao le hippocampus; Tjello e fumanoe amygdala ea basomedial, 'me ha ho liphetoho tse ileng tsa bonoa libakeng tse setseng. ΔFosB e kentsoe kahare ho cortex ea pele, caudate-putamen, li-nucleus accumbens le lateral amygdala. Kamano e arohaneng ea tikoloho lipakeng tsa polelo ea ΔFosB le boikemisetso ba CB suchR e fumanoe, hoo libaka tse nang le ts'ebetso e kholo ea ΔFosB li sa kang tsa bonts'a boikemisetso ba CB₁R le libaka ntle le tlhahiso ea ΔFosB li neng li e-na le boikemisetso bo boholo, libaka tse setseng li bonts'a maemo a mahareng a bobeli. Dun immunohistochemistry ho striatum e bonts'itse ts'ebelisano-'mōtoana ea CB₁R ka bobeli le ΔFosB ka liseleng le lisele tse nang le ₁FosB tse ntle tsa CB₁R. Polelo e susumetsoang ke THC ea ΔFosB e ne e le sieo ho litoeba tsa CB₁R tsa ho kokota. Lintlha tsena li fana ka maikutlo a hore liphofu tse ngotsoeng tsa ΔFosB li kanna tsa thibela takatso ea CB₁R le / kapa hore tlhahiso ea ΔFosB e ka fokotsoa ke takatso ea CB₁R.
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