Cell Mol Neurobiol. 2008 Feb; 28 (2): 157-72. Epub 2007 Nov 28.
mohloli o moholo
Lefapha la Neuropharmacology, Setsi sa Sechaba sa Tloho ea Lithethefatsi, Univesithi ea Peking, 38, Xue Yuan Road, Setereke sa Hai Dian, Beijing, 100083, China.
inahaneloang
Bokhoba ba lithethefatsi, bo khetholloang ka litekanyetso tse phahameng tsa ho oela hape, bo bonoa e le mofuta oa ho hloka taolo ea neuroadaptive. Kaha tsela ea extracellular-regated kinase (ERK) e bohlokoa haholo ho neuroplasticity bokong ba batho ba baholo, ho utloisisa karolo eo tsela e e bapalang ho bohlokoa ho utloisisa molek'hule o tlasa ts'ebeliso ea lithethefatsi le ho khutla hape.
Mona, re lekola lingoliloeng tse fetileng tse shebaneng le litlamorao tsa ho pepesehela cocaine, amphetamine, Delta (9) -tetrahydrocannabinol (THC), nicotine, morphine le joala ho lets'oao la ERK ho mesocorticolimbic dopamine system; liphetoho tsena tsa ho saena tsa ERK ho nahanoa hore li kentse letsoho litlamong tse khahlisang tsa lithethefatsi le phelisong e mpe ea nako e telele e bakoang ke ts'ebeliso e mpe ea lithethefatsi.
Joale re buisana ka litlatsetso tse ka bang teng tsa tsela ea ho emisa ea ERK e hlahisoang ke ho pepesetsoa hoa lithethefatsi tsa tlhekefetso le mekhoa ea tikoloho eo pele e neng e entsoe ka lithethefatsi. Kamora nako, re pheha khang ea hore kaha ts'ebetso ea ERK ke ts'ebetso ea bohlokoa ea limolek'hule tsa ho khutlisetsa thatohatsi ea sebaka se ikemetseng le taolo ea lithethefatsi, ho qhekella ha pharmacological tseleng ea ERK ke leano le ka sebelisang kalafo bakeng sa ho lemalla lithethefatsi.
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