Tšebeliso ea likokoana-hloko tse nang le lithethefatsi li eketsa Matla a Macha a Dendritic ho Khetha Nucleus Accumbens Neurons (2016)

Neuropsychopharmacology. 2016 Mar 16. Doi: 10.1038 / npp.2016.39.

Bine ea lipina1, Bubula N2, Li D2, Przybycien-Szymanska MM2, Bindokas VP3, Vezina P1,2.

inahaneloang

Ho pepesetsoa khafetsa ka amphetamine ho lebisa ho maemo a kopanyang le maikutlo a kopaneng. Mona re lekotse tlatsetso ea li-envirles tsa neuronal ka har'a li-nucleus accumbens (NAcc) ho mekhoa ena. Liphoofolo tse pepesitsoeng Amphetamine IP kapa sebakeng sa ventral tegmental (VTA) li bonts'itse karabelo ea sensomotor e khahlisang ha li qholotsoa le amphetamine libeke hamorao. Litsela ka bobeli tsa ho pepeseha le tsona li phahamisitse maemo a ΔFosB ho NAcc. Tšobotsi e 'ngoe ea li-neuron tsena tsa ΔFosB +, leha ho le joalo, e senotse hore amphetamine ha e na tšusumetso ho dendritic spine density kapa size, ho bontša hore li-neurons tsena ha li tsamaee ka liphetoho ho dendritic spine morphology e tsamaeang le polelo ea maikutlo a sa kopaneng. Liteko tse ling li bonts'a hore na li-neurons tsa NAcc li kenya letsoho joang ho hlahisa maemo a amanang. Mokhoa oa ho ithuta oa khethollo o ne o sebelisetsoa ho pepesa likhoto ho IP kapa VTA amphetamine e kanna ea ba Paired kapa ea sa lefelloang ka tšimo e bulehileng. Joalokaha ho lebelletsoe, ha ho bapisoa le Controls, likhoto tsa Paired tse tsamaisitsoeng IP amphetamine kamora moo li bonts'itse karabelo ea locomotor ha e qholotsoa le letsoai naheng e bulehileng, e le phello e tsamaeang le keketseho ea li-neurons tsa c-Fos + morafong oa Nacc. Tšobotsi e 'ngoe ea lisele tsena tsa c-Fos + e senotse hore likhoto tse ferekantsoeng li bonts'itse keketseho ea methapo ea methapo ea methapo le methapo ea methapo ea boholo bo bohareng ho NAcc. Ka lehlakoreng le leng, likhoto tse paired pejana tse neng li pepesitsoe VTA amphetamine ha li a bonts'a boemo ba boemo bo phahameng kapa polelo ea boemo ba c-Fos +. Ka kopanelo, liphetho tsena li hlahisa karolo ea li-neuron tsa c-Fos + ho medical NAcc le liphetoho tse potlakileng ho morphology ea methapo ea tsona ea dendritic polelong ea maemo a ts'oaroang ke tšusumetso ea maikutlo a amphetamine.

 

PMID: 26979294