Khatello ea kelello. 2014 Jan; 17 (1): 88-96. Doi: 10.3109 / 10253890.2013.850669. Epub 2013 Oct 31.
Poulin JF1, Laforest S, Drolet G.
inahaneloang
Thibelo le ho se sebetse hantle ho sebelisoa ka mokhoa o pharaletseng ho ithuta mokhoa oa karabo ea neuroendocrine ho khatello ea khatello ea maikutlo, empa litlamorao tsa boitšoaro ba mofuta ona oa khatello li lula li sa sebetse.
Thutong ena, re sebelisitse khetho ea sucrose le maze e phahameng ho ntlafatsa liphetoho tsa boitšoaro tse hlahisitsoeng ke matsatsi a 14 a thibelo ho likhoto. Re bone ho fokotseha ha khetho ea li-sucrose ho liphoofolo tse hatelletsoeng, haholo-holo sehlopheng se ikemetseng sa batho, empa ha ho phetoho ho boits'oaro ba ho tšoenyeha (joalo ka ha ho lekantsoe setulong se phahameng le se seng) matsatsi a mane kamora ho thibelo ea ho qetela.
Liphoofolong tsena tse ratoang ke batho ba bangata, re bone ho fokotseha ha polelo ea prroenkephalin mRNA ka har'a li-nucleus. Ho feta moo, re bone khokahano e matla pakeng tsa polelo ea enkephalin le khetho ea sucrose karolong ea khetla ea nucleus boemo bo tlase ba polelo ea pepephalin e amanang le khetho e tlase ea sucrose. Ho khahlisang, karohano ea karabo ea corticosterone e senoletse ho lieha hoa bolulo ho khutlisetsang sechaba se ikhethileng se batlang se le tlase, se fanang ka maikutlo a hore ho ba kotsing ea bofokoli bo bakoang ke khatello ea maikutlo ho ka amahanngoa le ho pepesetsoa nako e telele ea glucocorticoids.
Ho kenella ha ΔFosB ho boetse ho fokotsehile ho khetla ea "nucleus accumbens" ea batho ba ikhethileng ba tlase mme ntho ena e ngotsoeng e hlahisoa ho enkephalin neurons. Ha li kopantsoe hammoho, liphetho tsena li fana ka maikutlo a hore osFosB-Mediated downregulation ea enkephalin e bokellaneng ea li-nucleus e ka ba tlasa monyetla oa khatello ea maikutlo e sa feleng. Liteko tse ling li tla hlokahala ho tseba ho hlaka pakeng tsa liketsahalo tsena tse peli.
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