Ho ntlafatsa tikoloho ho thibela kokoana-hloko ea ho itlhokomela le ho etsa liphetoho ho hlalosang ΔFosB ho ratane ea cortex le nucleus accumbens (2014)

Maemo a ntlafatsang tikoloho a na le litlamorao tsa bohlokoa tlokotsing ea lithethefatsi tsa tlhekefetso tse latelang. Mosebetsi oa hona joale o ile oa hlahloba hore na ho pepesetsoa nicotine ka molomo ho fana ka tikoloho e ntlafalitsoeng. Likhoto tsa Wistar li ne li beoa tikolohong e tloaelehileng (SE, likhoto tse 'ne ka kara e tloaelehileng) kapa ka EE nakong ea matsatsi a 60 kamora ho khoesoa. EE e ne e na le liphoofolo tse robeli tse kenngoeng ka har'a mekotla e meholo e nang le lintho tse fapaneng tse kang mabokose, lintho tsa ho bapala le thepa ea ho lahla e neng e fetoloa makhetlo a mararo ka beke.

Kamora nako ena, liphoofolo li ile tsa pepesetsoa nikotine bakeng sa libeke tsa 3, moo liphoofolo li ileng tsa khetha ka bolokolohi pakeng tsa metsi le tharollo ea nicotine (0.006% ka metsing). Tšebeliso ea mafura e ne e hlahlojoa letsatsi le letsatsi. ΔFosB immunohistochemistry karolong ea pele ea cortex le li-nucleus tsa nucleus le tsona li ile tsa etsoa.

Likhoto tsa sehlopha sa EE li jele tharollo e nyane ea nicotine (0.25 ± 0.04 mg / kg / letsatsi) ho feta likhoto tsa SE (0.54 ± 0.05 mg / kg / day). EE e ile ea eketsa palo ea lisele tsa ΔFos-immunoreactive (ΔFos-ir) tse bokellaneng li bokellana mantlha le khetla le mokokotlong oa pele, ha li bapisoa le liphoofolo tse maemong a tloaelehileng.

Leha ho le joalo, likhoto tse pepesitsoeng ke nikotine ho SE li bonts'a lisele tse phahameng tsa ΔFos-ir bokong li bokellana mantlha le khetla ho feta likhoto tse sa bonoeng. Ts'ebeliso ea Nikotine ha e a ka ea fetola lisele tsa ΔFos-ir libakeng tsena tsa boko ho liphoofolo tsa EE. Liphetho tsena li ts'ehetsa mohopolo oa tšusumetso e ka bang teng ea ts'ireletso ea EE mabapi le kutloisiso ea moputso le nts'etsopele ea boitšoaro bo lematsang ho nicotine.