J Neurosci. 2015 Oct 7; 35 (40):13773-83. doi: 10.1523/JNEUROSCI.2083-15.2015.
Ntsu AL1, Gajewski PA1, Yang M2, Kechner ME1, Al Masraf BS1, Kennethy PJ3, Wang H1, Mazei-Robison MS1, Robison AJ4.
inahaneloang
Hippocampus (HPC) e tsejoa e bapala karolo ea bohlokoa ho ithuteng, mohato o itšetlehileng ka polasetiki ea synaptic; leha ho le joalo, mekhoa ea limolek'hule e bakileng sena ha e utloisisoe hantle. ΔFosB ke ntho e hatisang e kenang hohle bokong ka ho pepesehela lithethefatsi, khatello ea maikutlo le mefuta e meng ea lintho tse ling tse susumetsang mme e laola polasetiki ea synaptic le boitšoaro libakeng tse ling tsa boko, ho kenyelletsa le li-bokellase tsa nucleus. Re bonts'a mona hore ΔFosB e boetse e kenelletse libakeng tse katlase tsa HPC CA1 le DG ka ho ithuta ka sepakapaka le ho pepesetsoa tikoloho haufinyane. Morero oa thuto ea morao-rao e ne e le ho hlahloba karolo ea ΔFosB ho ithuta le ho hopola lintlha tse amanang le hippocampal. Re sebelisa phetisetso ea bongaka e tsamaeang le vaerase ho khutsisa tšebetso ea phetisetso ea ΔFosB ka ho hlahisa ΔJunD (moduleli ea seng a sa sebetse oa ΔFosB transcriptal function) kapa ho oxpxpress ΔFosB, re bonts'a hore HPC ΔFosB e laola ho ithuta le ho hopola. Ka ho khetheha, polelo ea ΔJunD ho HPC e ile ea sitisa ho ithuta le ho hopola ka betri ea mesebetsi e itšetlehileng ka hippocampal ho litoeba. Ka mokhoa o ts'oanang, kakaretso ea oFosB ho feta tekano le eona e sitisa ho ithuta. Polelo ea ΔJunD ho HPC ha e a ka ea ama matšoenyeho kapa moputso oa tlhaho, empa ΔFosB o ts'oaea ho feta tekano e entse hore motho a be le ts'ebetso ea ho tšoenyeha, a fana ka maikutlo a hore mayFosB e ka kena lipakeng tsa ho ikatisa ka hloko ho feta ho ithuta. Kamora nako, re fumane hore overexpression ea ΔFosB e eketsa masapo a methapo ea methapo ho lisele tsa piramite ea CA1, athe ΔJunD e fokolitse palo ea mefuta ea lesapo la mokokotlo le le holileng, e bonts'a hore ΔFosB e ka hlahisa litlamorao tsa eona ka boiphihlelo ba ts'ebetso ea synaptic ea HPC. Ka kopanelo, liphetho tsena li bontša ka kopanelo hore ΔFosB e bapala karolo ea bohlokoa ho HPC cellular morphology le ho ithuta le memori tse itšetlehileng ka HPC.
TLHALOSO EA SIGNIFICANCE:
Ho kopanngoa ha mehopolo ea rona e hlakileng ho etsahala kahare ho hippocampus, mme ke sebakeng sena sa boko moo lits'ebetso tsa limolek'hule le tsa cellular li ithutoang haholo. Rea tseba hore likhokahano pakeng tsa li-neuron tsa hippocampal li thehoa, li felisoa, li matlafatsoa le ho fokotsoa nakong ea ho ithuta, 'me rea tseba hore methati e meng ea ts'ebetso ena e kenyelletsa liphetoho phetisong ea mefuta e ikhethileng. Leha ho le joalo, lintlha tse ikhethileng tse amanang le ts'ebetso ena ha li utloisisehe ka botlalo. Mona, re bonts'a hore karolo ea transcript factor ΔFosB e kentsoe hippocampus ka ho ithuta, ho laola sebopeho sa li-synapses tsa hippocampal, mme e hlokahala bakeng sa tlhahiso ea memori, ho bula menyetla e mengata e mecha ea molao oa ho hippocampal transcriptal.
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LINKOTSO:
dendritic spines; hippocampus; ho ithuta; sengoloa; ΔFosB
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