Neurosci Lett. 2015 Dec 3. pii: S0304-3940 (15) 30290-1. Doi: 10.1016 / j.neulet.2015.11.052
Zhang Q1, Liu Q2, Li T2, Liu Y2, Wang L3, Zhang Z4, Liu H4, Hu M5, Qiao Y6, Niu H7.
inahaneloang
Patlisiso lilemong tse leshome tse fetileng e bontšitse hore NMDA receptor (NMDAR) e na le karolo ea bohlokoa ho polasetiki ea opiate-induction leural le boits'oaro. Ntle le moo, maemo a eketsehang a liprotheine tse kang FosB (FosB / ΔFosB) a fumanoe a amana le boits'oaro ba morphine ba ho tlohela. Leha ho le joalo, kamano pakeng tsa NMDAR le FosB / ΔFosB libakeng tse amehang tsa boko nakong ea ho khaotsa morphine ha e tsejoe haholo. Thutong ena, re ikemiselitse ho etsa lipatlisiso ka maemo a NMDAR le maemo a FosB / ΔFosB libakeng tse ngata tsa boko le hore na li amana le likarolo tse tebileng tsa boko nakong ea ho thibeloa ha morphine. Quantunative immunohistochemistry e ile ea amoheloa ho ea leka liteko tsa NMDAR le FosB / ΔfosB nakong ea ho tlosoa ha morphine ho litoeba. Manane a eketsehang a NMDAR le FosB / ΔFosB a fumanoe sekepeng sa nucleus accumbens (AcbC), nucleus accumbens shell (AcbSh), karolo e bohareng ea amygdaloid nucleuscapsular (CeC), sebaka sa ventral tegmental (VTA) le cingrate cortex (Cg). Ho ngola habeli-immunofluorescence ho bontšitse hore NMDAR e ile ea ngoloa le Fos / ΔFosB libakeng tsena tse hlano. Liphetho tsena li fana ka maikutlo a hore libaka tse fapaneng tsa "phenotypic" li pakeng tsa NMDAR le Fos / ΔFosB nakong ea ho tlosoa ha morphine, joalo ka khothatso (AcbC, AcbSh), limbic (CeC, VTA) le molaoli oa tsamaiso ea (Cg), 'me e kanna ea ba liphofu tsa mantlha tsa NMDAR le Fos / ΔfosB e amang boits'oaro ba morphine.
LINKOTSO: Liprotheine tsa FosB; Receptor ea NMDA; tsamaiso ea maoto le matsoho; morphine; tlosa
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