Neuropsychopharmacology. 2014 Apr 29. Doi: 10.1038 / npp.2014.98.
Velázquez-Sánchez C1, Ferragud A1, Moore CF1, Everitt BJ2, Sabino V1, Cottone P1.
inahaneloang
Ho susumetsoa ke tšobotsi eo hangata e bonahatsoang hangata ho batho ba lemaletseng lithethefatsi, empa hape le ho batho ba nang le tšenyo e kholo litabeng tsa boitšoaro. Leha ho le joalo, hore na ho potlakisa ho rera ho fepa pele ho sa laoleheng ha ho tsejoe. Phuputsong ena re fane ka maikutlo a hore ho na le tšekamelo e phahameng ea ho susumetsa motho kapele mme e fana ka monyetla oa ho ba tsietsing ea ho lemalla lijo.
Bakeng sa morero ona, re koetlisitse likhalase tsa banna ho fepa likhoto tsa Wistar ka mokhoa o fapaneng oa ts'ebetso ea litheko tse tlase tsa karabelo (DRL) ho khetha likhoto tse phahameng le tse sa tsamaeeng letho. Ka mor'a moo, re ile ra lumella likhoto tse tlase le tse phahameng haholo hore li itaole Lijo tse matlafatsang haholo (Sehlopha se tsebahalang) kapa se jang kamehla (Sehlopha sa Chow) mekhahlelong ea 1 h letsatsi le leng le le leng, tlasa tekanyo e behiloeng (FR) 1, FR3, FR5, le tlasa kemiso e tsoelang pele (PR) ea likhakanyo.
Ntle le moo, re ile ra leka ho qhekelloa ha lijo ka har'a likhoto tse tlase le tse phahameng haholo ka ho lekanya lijo tse jeoang moqoqong, karolo e bulehileng ea liteko tse bobebe / tse lefifi.
Kamora nako, re ile ra lekanya polelo ea sengoloa sa criptionFosB khetla le karolo ea bohlokoa ea li-nucleus tse tšoaeang li-liphetoho tsa neuroadaptive kamora ho pepeseha ha lithethefatsi tse lemalloang.
Tlhahiso-leseling eo re e fumaneng e bonts'a hore ho qhekella ke mokhoa o supang nts'etsopele ea boitšoaro bo joalo ba bokhoba ba lijo, ho kenyelletsa: i) ho ja lijo tse ngata, ii) khothatso e phahameng ea lijo, le iii) lijo tse qobelloang, ha likhoto li fuoa monyetla oa ho fumana lijo tse matla haholo. lijo tse monate.
Ntle le moo, re bonts'a hore tlatsetso ea ts'ebeliso ea litheko tsa lijo lithutong tse phahameng tse potlakileng e tšoauoa ka polelo e eketsehang ea transcript factor criptionFosB ho khetla ea nucleus accumbens.
Liphetho tsena li paka hore ho iketelletsa pele ho fana ka matla a ho eketseha ha lijo tse matlafatsang tse sa laoleheng.
Neuropsychopharmacology e amohetse peview inthaneteng, 29 April 2014. Doi: 10.1038 / npp.2014.98.
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