Khopolo-taba. 2016 Oct 29; 335: 20-9. Doi: 10.1016 / j.neuroscience.2016.08.022.
Li L1, Qiao C.2, Chen G3, Qian H4, Hou Y5, Li T6, Liu X7.
inahaneloang
Tšebeliso e sa feleng ea litlatsetso tse ngata tsa psychomotor e lebisa tlhokomelong ea boits'oaro, ka lebaka la eona e arolelana mekhoa e tloaelehileng ka ho oela hape, bafuputsi ba bangata ba sebelisa mohlala oa eona oa phoofolo ho hlahloba mekhoa ea methapo ea kutlo. Boithuto ba morao-rao bo bontšitse hore li-N-methyl-d-aspartate receptors (NMDARs) li na le tšusumetso ho maikutlo a susumetsang a kelello a psychomotor. Leha ho le joalo, ts'ebetso ea li-NMDAR tse nang le GluN2B le li-Cascade tsa bona tse tlase tse fumanehang moqoqong le phihlello ea maikutlo a boitšoaro ho methamphetamine (METH) ha e so ka e hlahlojoa. Thutong ena, 2.5, 5, le 10mg / kg ifenprodil, inhibitor e ikhethileng ea GluN2B, e sebelisitsoe ho hlahloba ts'ebetso ea li-receptors tsena ka mekhahlelo e fapaneng ea maikutlo a boitšoaro ho METH ka litoeba. Joale, ho sebelisoa blot bophirima, Ras, pERK1 / 2 / 1, le maemo a ΔFosB ho preortal cortex (PFc), li-nucleus accumbens (NAc), le caudate putamen (CPu) li fumanoe. Liphetho tsa boits'oaro li bonts'itse hore lethalinyana le tlase haeba le kenella ho fumana le ho fana ka maikutlo a boits'oaro ho TOTH haholo. Tlhahlobo ea blot ea Bophirimela e senoletse hore ente ea pele ea ente ea lethathamo le tlase la lethathamo la tse fumanehang e fumanehang ka bongata REP, PERK2 / 1 / ERK2 / 1, le li-protein tsa ΔFosB ho CPu. Leha ho le joalo, kalafo ea pele ho polelo e amme feela liphetoho tsa Ras le pERK2 / 1 / ERK2 / 1 maemong a CPu.
Ho feta moo, tsamaiso ea METSI e sa foleng e ile ea eketseha boemo ba pERK1 / 2 / ERK1 / 2 ho NAc. Qetellong, li-NMDAR tse nang le GluN2B li kenya letsoho ho fumana le ho fana ka maikutlo a boits'oaro ho METH ka litoeba. Ntle le moo, karolo ea phihlello e kanna ea kopanngoa le papali ea Ras-ERK1 / 2-ΔFosB ho CPu ha karolo ea polelo e ka laoloa ke papali ea Ras-ERK1 / 2 ho CPu.
LINKOTSO: N-methyl-d-aspartate receptor; maikutlo a boits'oaro; caudate putamen; ifenprodil; methamphetamine; li-nucleus
PMID: 27544406
DOI: 10.1016 / j.neuroscience.2016.08.022
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