Neurobiol Ithute Mem. 2016 Dec; 136: 127-138. Doi: 10.1016 / j.nlm.2016.10.002. Epub 2016 Oct 5.
Baker KD1, Reichelt AC2.
inahaneloang
Mathata a ho tšoenyeha le botena li atile haholo ho bacha le ho batho ba baholo. Leha ho na le bopaki bo ntseng bo eketseha ba hore tšebeliso e fetelletseng ea "mafura" a nang le mafura a mangata / tsoekere e phahameng e lebisa liphellong tse mpe tsa methapo ea kutlo, ha ho tsejoe hanyane ka litlamorao tsa lijo tse hlabosehang mehopolong ea maikutlo le molaong oa tšabo. Litekong tsa hajoale re hlahlobile litlamorao tsa ts'ebeliso ea letsatsi le letsatsi ea 2h ea lijo tse nang le mafura a mangata / tsoekere e phahameng (HFHS) nakong eohle ea bocha ka tšabo ea tšabo le boits'oaro bo ts'oanang le matšoenyeho ho likhoto tsa batho ba baholo. Likhoto tse pepesitsoeng phepong ea HFHS li bonts'itse ho fokola ha tšabo le ho eketsa boits'oaro bo ts'oanang le khatello ea maikutlo ha ho bapisoa le likhoto tse fepang lijo tse tloaelehileng. Likhoto tse fepehileng ke HFHS li bonts'itse liphetoho tse bakoang ke phepo ea mosebetsi oa prefrontal cortex (PFC) o fumanoeng ka polelo e fetotsoeng ea li-interneuron tsa "GABAergic parvalbumin-expression" inhibitory interneurons le "factor transcript" ΔFosB e bokellanang ho PFC ka lebaka la tšusumetso e sa foleng. Litlhahlobo tsa Immunohistochemical tsa PFC e bohareng li senoletse hore liphoofolo tse fepang lijo tsa HFHS li na le lisele tse fokolang tsa parvalbumin le maemo a eketsehileng a polelo ea FosB / osBFosB ka infralimbic cortex, sebaka se amehang ho kopaneng ha tšabo e felile. Ho ne ho e-na le tloaelo ea ho eketsa boits'ireletso ba mmele ba IBA-1, sesupo sa ts'ebetso ea microglial, ka infralimbic cortex kamora ho pepesetsoa lijo tsa HFHS empa polelo ea extracellular glycoprotein reelin e ne e sa amehe. Liphuputso tsena li bonts'a hore phepo ea HFHS nakong ea bocha e amahanngoa le phokotso ea "prefrontal" parvalbumin neurons le ts'oaetso e mpe ea ts'abo ha motho e moholo. Litholoana tse mpe tsa lijo tsa HFHS mokhoeng oa taolo ea ts'abo li ka fokotsa ts'oaetso ho batho ba batenya ho tlola nts'etsopele ea mathata a ho tšoenyeha.
LINKOTSO: Bocha; Ho felisoa; Tšabo; Ho Nona Haholo; Parvalbumin; Pele ho cortex
PMID: 27720810
DOI: 10.1016 / j.nlm.2016.10.002
;