Ho khahlisoa ha FosB / DeltaFosB ka mekhoa e amanang le tsamaiso ea kelello nakong ea morphine ho itšetleha le ho tlosoa (2010)

• ¹Lefapha la Pharmacology, Sekolo sa Bongaka sa Univesithi, Murcia, Spain. [imeile e sirelelitsoe]

Ntho e hatisitsoeng DeltaFosB e kenyelletsoa ka har'a li-nucleus accumbens (NAc) ke lithethefatsi tsa tlhekefetso. Phuputso ena e ne e etselitsoe ho lekola liphetoho tse ka bang teng ponahalong ea FosB / DeltaFosB maemong a khatello ea khatello ea kelello le extrahypothalamic nakong ea ts'ebeliso ea morphine le ho intša.

Likhoto li ne li etsoa ho latela morphine mme ka letsatsi 8, li ne li kenngoa ka letsoai kapa naloxone. U sebelisa immunohistochemistry le blot bophirima, polelo ea FosB / DeltaFosB, tyrosine hydroxylase (TH), corticotropin-releasing factor (CRF) le pro-dynorphin (DYN) e lekantsoe ka li-nuclei tse fapaneng ho tloha tsamaisong ea khatello ea kelello litsing tse itšetlehileng ka morphine le ka mor'a morphine Ho ntša. Ntle le moo, re ithutile polelo ea FosB / DeltaFosB ho CRF-, TH- le DYN-neurons e ntle. FosB / DeltaFosB e qalile ka mor'a ts'ebetso ea morphine e sa foleng karolong ea parothellular ea hypothalamic paraventricular nucleus (PVN), NAc-shell, mookotaba oa bethe ea stria terminalis, amygdala e bohareng le A (2) noradrenergic karolo ea nucleus treususitarius (NTS- A (2). Ho itšetleha ka Morphine le ho tlosoa ho tlatselitse keketseho ea FosB / DeltaFosB-TH le FosB / DeltaFosB-CRF habeli ho NTS-A (2) le PVN, ka ho latellana, ntle le keketseho ea maemo a TH ho NTS-A (2) le polelo ea CRF ho PVN.

Lintlha tsena li bonts'a hore neuroadaptation ea lintho tse lemalloang, tse bonoang e le pokello ea FosB / DeltaFosB, ha e felle feela lipotolohong tsa moputso empa e ka boela ea hlaha libakeng tse ling tsa boko, joalo ka tsamaiso ea khatello ea kelello, tse reriloeng hore li amanang ka ho toba le bokhoba ba tahi. .