Ho lebisa tlhokomelo ea Gene Regulator ka Moputso oa Bongoa Potoloho Eyed e le Kalafo
Bo-rasaense ba fumane mokhoa o thusang ho hlalosa ho tiea ha khatello ea kelello, tšoaetso ea ho tepella maikutlong le hore na basebetsi ba nang le bothata ba ho tepella maikutlo ba sebetsa joang. Liphuputso tse ncha, potolohong ea moputso oa mouse le botho ba motho, li hlahisitse letlooa le phahameng la theknoloji bakeng sa lik'hemik'hale tse matlafatsang ketso ea liphatsa tsa lefutso tsa lefutso moo, e bitsoang deltaFosB.
Sesebelisoa se matla sa limolek'hule - se bitsoang transcript factor - kahare ho li-neuron, deltaFosB e tima le ho tima liphatsa tsa lefutso tse ngata, e leng se hlahisang tlhahiso ea liprotheine tse etsang mesebetsi ea sele.
"Re fumane hore ho baka deltaFosB setsing sa potoloho ea moputso hoa hlokahala ebile ho lekane bakeng sa mamello; e sireletsa litoeba hore li se ke tsa ba le lefu le kang la khatello ea maikutlo kamora khatello ea maikutlo e sa foleng ea sechaba, "ho hlalositse Eric Nestler, MD, oa Mount Sinai School of Medicine, ea etelletseng pele sehlopha sa lipatlisiso, se neng se tšehelitsoe ke Setsi sa Naha sa Bophelo sa Setsi sa Bophelo bo Botle ba Kelello. (NIMH).
“Ho imeloa kelellong ho ka felisa lefu lena la ho ikhula sechabeng ka ho eketsa deltaFosB. Ho feta moo, deltaFosB e felile ka ho hlakileng bokong ba batho ba nang le khatello ea maikutlo. Kahoo, ho kenyelletsoa ha protheine ena ke phetoho e ntle e re thusang ho sebetsana le khatello ea maikutlo, ka hona re ts'epa ho fumana mekhoa ea ho e fokotsa ka bongaka, "ho eketsa Nestler, eo hape a tsamaisang projeke e ntseng e tsoela pele ea ho hlahloba likarolo.
Nestler le basebetsi-'moho ba tlaleha liphuputso tse susumelitseng ho tsoma Inthaneteng May 16, 2010 koranteng ea Nature Neuroscience.
“Patlo ena ea limolek'hule tse nyane (http://projectreporter.nih.gov/project_info_description.cfm?aid=7821642&icde=3502192) e eketsa liketso tsa deltaFosB e na le tšepiso bakeng sa ntshetsopele ea sehlopha se secha sa ho mamella-ho eketsa phekolo ea ho tepella maikutlo (http://www.nimh.nih.gov/health/topics/depression/index.shtml), ”Ho boletse motsamaisi oa NIMH Thomas R. Insel. "Morero, o tšehelitsoe ka chelete tlasa Molao oa Amerika oa Pholoso le Ts'ireletso hape oa 2009 (http://www.nimh.nih.gov/about/director/2009/nimh-and-the-recovery-act.shtml), ke mohlala o makatsang oa hore na lits'oants'o tsa litoeba li ka lateloa kapele joang 'me tsa fetoleloa lits'ebetsong tsa bongaka tse ka bang teng. ”
DeltaFosB e sebetsa haholoanyane mofuteng oa moputso, o bitsoang nucleus accumbens (sheba setšoantšo se ka tlase), ho feta karolo leha e le efe ea boko. Tšebeliso e sa feleng ea lithethefatsi tsa tlhekefetso - kapa esita le meputso ea tlhaho (http://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local&v2=1&ti=1,1&Search_Arg=101507191&Search_Code=0359&CNT=20&SID=1) joalo ka lijo tse fetelletseng, thobalano kapa boikoetliso - butle-butle li ka baka maemo a ntseng a eketseha a sengoloa sena sebakeng sa moputso. Nestler le basebetsi-'moho le eena ba bontšitse hore keketseho ena ea deltaFosB qetellong e ka lebisa liphetohong tse tšoarellang liseleng tse eketsang likarabo tse khotsofatsang linthong tse joalo, ho koetela moputso oa motho ka mong - ho lemalla.
Phuputso e ncha litabeng tsa litoeba le tsa batho ka mor'a lefu le tiisa hore moputso o tšoanang oa potoloho o senyehile ka tsela e tšoanang (le hoja e le ka tlase ho feta lithethefatsi tsa tlhekefetso) ka ho tepella maikutlong ka litla-morao tsa khatello ea kelello sebakeng sa deltaFosB.
Hangata bakuli ba tepeletseng maikutlo ha ba na tšusumetso le bokhoni ba ho fumana moputso kapa monate - mme ho tepella maikutlo le tahi hangata li tsamaea hammoho. Ha e le hantle, litoeba tse hlasetsoeng ke lefu la ho tepella maikutlong li bontša likarabo tse ntlafetseng ho lithethefatsi tsa tlhekefetso, bafuputsi ba fumane.
Empa ho tšoana ho fela moo. Hobane, ha ho e-na le phapanyetsano ea likhutsana le litlhapi tse fokolang mokhoeng oa boipheliso, bafuputsi ba fumane hore e boetse e sireletsa khatello ea maikutlo ea ho tepella maikutlong. Hoa bonahala hore khatello ea kelello e etsa hore motsoako oa khatiso o fetole motsoako o fapaneng oa cell cell nucleus accumbens - ho sebetsa ka mefuta e fapaneng ea li-receptor - ho feta ho sebelisa lithethefatsi le meputso ea tlhaho, mohlomong litlaleho tsa liphello tse sa tšoaneng.
Bafuputsi ba ile ba hlahloba ho sebetsa ha deltaFosB ka mohlala oa mouse oa ho tepella maikutlong (http://www.nimh.nih.gov/science-news/2006/mice-lacking-social-memory-molecule-take-bullying-in-stride.shtml). Hangata bakuli ba tepeletseng maikutlo ba tlohela ho kopana le sechaba, litoeba tse pepesetsoeng ke mabifi ka mouse e fapaneng ka ho fetisisa letsatsi le leng le le leng bakeng sa matsatsi a 10 hangata li hlōloa ke sechaba; ba qoba ka matla litoeba tse ling, esita le libeke tse seng kae hamorao.
Tse ling tsa lithuto tsa bohlokoa boemong ba moputso oa boko:
- Palo ea deltaFosB e bakoa ke khatello ea kelello e tsitsitseng kapa ho tiea ho hlaolela ho itšoara ha maikutlo ho tepella maikutlong. E ile ea loantša tšekamelo e matla ea ho ithuta setsoalle, kapa ho etsa hore ho be le phihlelo e matla ho litoeba tsohle.
- Ho qhekella ha deltaFosB ho ne ho hlokahala hore motho ea nang le bothata ba ho tepella maikutlo a fluoxetine (Prozac) a fetole khatello ea maikutlo e bakoang ke khatello ea maikutlo.
- Ho ikarola ha nako e telele ho tsoa molekong oa tikoloho ho fokotsehile maemo a deltaFosB, ho eketsa ts'oaetso ea ho itšoara joaloka maikutlo.
- Har'a mefuta e mengata ea liphatsa tsa lefutso e laoloang ke litlhapi tsa FosB, liphatsa tsa lefutso tse etsang protein e bitsoang AMPA receptor ke tsa bohlokoa bakeng sa ho mamella - kapa ho sireletsa litoeba tse tsoang khatellong ea maikutlo. Mokete oa AMPA ke protheine e nang le methapo e matlafatsang ketsahalo ea sele ha e tlama ho lik'hemik'hale messenger glutamate.
- Mesebetsi e eketsehileng ea li-neurons e bakoa ke ho utloisisa haholoanyane li-receptor tsa AMPA ho tlosa maikutlo a eketsehileng ho boitšoaro bo kang ba khatello ea maikutlo.
- Ho qhekelloa ha deltaFosB ho khutsisitse methapo ea kutlo le ho sirelletsoa khahlano le khatello ea maikutlo ka ho hatella kutloisiso ea AMPA receptors ho glutamate.
- Likokoana-hloko tsa lefu la ho qetela tsa lefu la bakuli ba tepeletseng maikutlo li ne li e-na le hoo e ka bang halofo feela ea FosB ea sefofane e le ea taolo, e fana ka maikutlo a hore karabo e mpe ea phekolo ea ho imeloa kelellong e ka 'na ea e-ba le tšoaetso e fokolang ea karolo e ngotsoeng ea ntho e ngotsoeng.
Lefapha la phosolo le fokotsehilengFosB mofuteng oa moputso o ka 'na oa thusa ho ikarabella bakeng sa tšusumetso e fosahetseng le moputso oa boitšoaro bo bonoang ke ho tepella maikutlong, ho boletse Nestler. Ho ho matlafatsa ho bonahala ho thusa motho hore a phehelle boitšoaro bo laoloang ke morero ho sa tsotellehe khatello ea maikutlo.
Tlhahlobo e phahameng ea theknoloji (http://www.nimh.nih.gov/science-news/2009/high-tech-robots-efforts-bear-fruit-thanks-to-nih-roadmap.shtml) bakeng sa limolek'hule tse matlafatsang DeltaFosB, tse tšehetsoang ke thuso ea Recovery Act, li ka lebisa tlhokomelong ea meriana e tla thusa batho ho sebetsana ka katleho le khatello ea kelello e sa foleng. Limolek'hule li ka 'na tsa sebelisoa e le li-tracers tse buang ka boko bokopi bo nahanang ho hlahloba tsoelo-pele ea bakuli ba tepeletseng ka ho bonahatsa liphetoho marakeng a FosB, ho boletse Nestler.
Morero oa NIMH ke ho fetola kutloisiso le phekolo ea mafu a kelello ka lipatlisiso tsa mantlha le tsa bongaka, ho bula tsela ea ho thibela, ho fola le ho phekola. Bakeng sa boitsebiso bo eketsehileng, etela Www.nimh.nih.gov.
Mabapi le Mekhatlo ea Sechaba ea Bophelo (NIH): NIH, lefapha la lipatlisiso tsa bongaka la naha, le kenyelletsa litsi le litsi tse 27 mme ke karolo ea Lefapha la Bophelo le Litšebeletso tsa Botho la US. NIH ke lefapha la mantlha la koporasi le tsamaisang le ho ts'ehetsa lipatlisiso tsa bongaka tsa mantlha, tsa bongaka le phetolelo, mme le ntse le batlisisa lisosa, kalafo le kalafo ea mafu a tloaelehileng le a sa tloaelehang. Bakeng sa tlhaiso-leseling e batsi ka NIH le mananeo a eona, etela http://www.nih.gov.
NIH… Ho Fetolela Tsebiso ho Bophelo ®
Mesebetsi e hlalositsoeng phalong ena e ntse e tšehetsoa ka molao oa American Recovery le Reinvestment Act (ARRA). Ho latalla tsoelo-pele ea mesebetsi ea HHS e tšehetsoang ka ARRA, etela www.hhs.gov/recovery. Ho latela litefiso tsohle tsa federal tse fanoeng ka ARRA, etela www.recovery.gov.
Tlhaloso:
DeltaFosB ka lipotolohong tsa moputso oa bokooa e kopana le botsitso ho khatello ea kelello le likarabo tse sithabetsang. Vialou V, Robison AJ, LaPlant QC, Covington III HE, Dietz DM, Ohnishi YN, Mouson E, Rush III AJ, Watts EL, Wallace DL, Iniguez SD, Ohnishi YH, Steiner MA, Warren B, Krishnan V, Neve RL, Ghose S, Beron O, CA Tamminga, Nestler EJ. NatNeurosci. Epub 2010 ka May 16.
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