Behav Brain Res 2011 Mar 1; 217 (2): 354-62. Epub 2010 Nov 9.
Greenwood BN, Foley TE, Le TV, PV e matla, Lilyridge AB, Day He, Fleshner M.
Lefapha la Tlhaho ea 'Mele e Akaretsang, Setsi sa Neuroscience, Univesithi ea Colado, Boulder, CO, USA. [imeile e sirelelitsoe]
inahaneloang
Tsela ea moputso oa mesolimbic e bohlokoa ho mafu a kelello a amanang le khatello ea maikutlo mme ke sepheo se ka bang teng sa polasetiki e ka tlas'a khatello ea khatello e hlahisoang ke boikoetliso bo iphetahatsang ba boithaopo. Ha ho tsejoe, leha ho le joalo, hore na likhoto li fumana phihlello ea nako e telele ea mabili a tsamaeang e le moputso, kapa haeba moputso oa boikoetliso o phetoang ka boithaopo o hlahisa liphetoho tsa polasetiki ho mesolimbicvuzo neurocircuitry. Lithutong tsa hajoale, motho e moholo ea lilemong, likhofu tsa Fischer 344 tse tona li lumelletse ho fihlella ka boithatelo ho mabili a matha bakeng sa libeke tsa 6, empa eseng libeke tsa 2, li fumane lebili le tsamaeang le moputso, joalo ka ha le lekantsoe ke maemo a ratang sebaka (CPP). E tsamaellana le litlaleho tsa pele le data ea boits'oaro, libeke tsa 6 tsa ho tsamaisoa ke mabili li eketsehile ΔFosB / FosB immunoreactivity ho nucleus accumbens (Acb). Ntle le moo, tekanyo e lekanyelitsoeng ho li-hybridization e ile ea senola hore libeke tsa 6 tsa mabelo a matha, ha li bapisoa le matlo a lutseng, ho eketseha ha li-tyrosine hydroxylase (TH) mRNA ka har'a sebaka sa karo-karolelano ea (VTA), litekanyetso tse eketsehang tsa delta opioid receptor (DOR) mRNA ho Acb khetla, le litekanyo tse fokotsehileng tsa dopamine receptor (DR) -D2 mRNA moqomong oa Acb. Liphetho li bontsa hore ho ikoetlisa khafetsa ka boithaopo hoa putsa ebile ho fetola sengoloa sa gene ho mesolimbicvuzo neurocircuitry. Litholoana tse itšetlehileng ka nako ea wheelchair tse tsamaeang le CPP li khothaletsa hore ha libeke tsa lebelo li ntse li tsoela pele, litlamorao tse thabisang tsa ho tsamaea ka mabili a boithatelo li ka lieha ho fetoha moetong o sa sebetseng ka hona ho fana ka tšehetso e matla bakeng sa CPP. Ho ba le polasetiki ho bonoeng ho ka kenya letsoho mekhoeng eo ka eona boikoetliso bo fokotsang likotsi le ho teba ha mathata a tlhekefetso ea lithethefatsi, ho fetola thepa ea litheko tsa tlhekefetso, le ho thusa ho sebetsana ka katleho le khatello ea maikutlo.
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