Neuropharmacology. 2016 Nov; 110 (Pt A): 135-42. Doi: 10.1016 / j.neuropharm.2016.07.009.
Morais-Silva G1, Alves GC2, Marin MT3.
inahaneloang
Ho lemalla joala ke bothata bo tebileng ba bophelo bo botle ba sechaba bo ntseng bo hloka kalafo e sebetsang ea meriana. Ntho ea bohlokoa ho nts'etsopele le ho boloka lefu lena ke ho qaloa ha neuroadaptations tseleng ea boko ba mesocorticolimbic holim 'a tlhekefetso e sa feleng ea ethanol. Ka kakaretso, li-neuroadaptations tsena ha li sebetse hantle 'me li ama litsamaiso tse ngata tsa methapo ea kutlo le limolek'hule tse ikhethang. E 'ngoe ea limolek'hule tsena ke ΔFosB, ntho e fetoleloang e fetotsoeng kamora tšebeliso e mpe ea lithethefatsi. Boitlhotlhollo ba boitšoaro bo botle ke mohlala oa bohlokoa thutong ea li-neuroadaptations tse amanang le bokhoba. Mesebetsi ea morao-rao e bontšitse karolo ea ho se leka-lekane ha glutamatergic neurotransication matšoao a fumanoang ho batho ba lemalloang. Ka kutloisiso ena, kalafo e nang le N-acetylcysteine, tlhahiso ea l-cysteine e sebetsang ka ho khutlisetsa likhakanyo tsa extarynaptic tsa glutamate ka ts'ebetso ea antiporter ea cystine-glutamate, e bonts'itse liphetho tse matlafatsang kalafong ea ho lemalla. Kahoo, mohlala oa phoofolo oa maikutlo a boitšoaro o ile oa sebelisoa ho lekola litlamorao tsa kalafo ea N-acetylcysteine ts'ebetsong ea phetoho ea boitšoaro le ea limolek'hule tse hlahisoang ke tsamaiso e sa feleng ea ethanol. Linta tsa Switzerland li ne li le tlas'a matsatsi a 13 a taolo ea ethanol ea letsatsi le letsatsi ho susumetsa maikutlo a boitšoaro. Lihora tse peli pele ho tsamaiso e ngoe le e 'ngoe ea ethanol le tlhahlobo e' ngoe ea liphoofolo, liphoofolo li ile tsa fuoa liente tsa N-acetylcysteine tse kenang kahare. Hang ka mor'a seboka sa ho qetela sa tlhahlobo, mehopolo ea bona e ile ea tlosoa bakeng sa ΔFosB le cystine-glutamate antiporter quanuction. Ho ile ha fumaneha hore kalafo ea N-acetylcysteine e thibetse sensanization-ethisol-sensitization ea boitšoaro, keketseho ea litaba tsa inFosB ka cortex ea pele, le phokotso ea eona ea li-nucleus accumbens. Liphetho li bontša ts'ebeliso ea N-acetylcysteine e ka hlahang matsatsing a amanang le ethanol.
LINKOTSO: Bokhoba ba tahi; Glutamate; N-acetylcysteine; Li-bokella tsa nyutlelie; Pele ho cortex; xct antiporter
PMID: 27401790
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