Protein Kinase G e laola ho lokolloa ha Dopamine, ho hlalosana ha ΔFosB le mosebetsi oa ho hlahisa libaka ka morao ka mor'a Ts'ebetsong ea Ts'ebetso ea Cocaine: Ho kenngoa ha Dopamine D2 Receptors (2013)

Neurochem Res. 2013 Apr 13.

Lee DK, Oh JH, Shim YB, Choe ES.

mohloli o moholo

Lefapha la Saense ea Tlhaho, Univesithi ea Naha ea Pusan, 63-2 Pusandaehak-ro, Kumjeong-gu, Pusan, 609-735, Korea.

inahaneloang

Protein kinase G (PKG) activation e kentsoe letsoho taolong ea polasetiki ea synaptic bokong. Phuputso ena e ile ea etsoa ho tseba ho nka karolo ha li-receptor tsa PKG tse amanang le PKG taolong ea tokollo ea dopamine, polelo ea osBFosB le ts'ebetso ea locomotor ho arabela ho pepeseha khafetsa ha cocaine. Liente tse phetoang khafetsa tsa k'hok'heine (2 mg / kg), hang ka letsatsi matsatsi a supileng a latellanang, keketseho ea cyclic guanosine monophosphate (cGMP) le likhakanyo tsa extracellular dopamine ho dorsal striatum. Thibelo ea neuronal nitric oxide synthase (nNOS), cGMP kapa PKG le ts'ehetso ea li-receptor tsa D2 li fokolitse keketseho e phetoang khafetsa e bakoang ke cocaine ea likhahla tsa dopamine. Liphetho tse tšoanang li fumanoe ka ho kopanya nNOS, cGMP kapa PKG inhibition ka ho hlasimolla li-receptor tsa D20. Ho ts'oana le tlhaiso-leseling ena, thibelo ea PKG, tšusumetso ea receptor ea D2, le ho kopanya thibelo ea PKG le tšusumetso ea li-receptor tsa D2 ho fokolitse keketseho e phetoang khafetsa e bakoang ke cocaine ho polelo ea osBFosB le ts'ebetso ea locomotor.

Liphumano tsena li fana ka maikutlo a hore taolo ea li-receptors tsa D2 ka ts'ebetso ea PKG ka mor'a ho ts'oara khafetsa koae e ikarabella bakeng sa tokollo ea dopamine le ho boloka liphetoho tsa nako e telele ho polelo ea gene litsing tsa dopamine le gamma-aminobutyric acid neurons ea dorsal striatum, ka ho latellana. Keketseho ena e ka tlatsetsa phetohong ea boits'oaro ho arabela khafetsa ho pepesoa le koae.