Int J Neuropsychopharmacol. 2016 Nov 4. pii: pyw097. doi: 10.1093 / ijnp / pyw097.
Lafragette A1,2, Bardo MT3, Lardeux V1,2, Solinas M1,2, Thiriet N4,2.
inahaneloang
LITLHAHISO:
Ho pepesetsoa ha nakoana tikolohong e ntlafalitsoeng (EE) ho bontšitsoe ho fokotsa litlamorao tsa locomotor tse hlahisoang ke ente ea khafetsa ea cocaine le ho fetola maemo a liprotheine a baselini le a koae ka ho felletseng ka har'a transense factor delta-FosB (ΔFosB) maemong ohle a litoeba. Thutong ena, re ikemiselitse ho supa hore na profil ea ΔFosB e hlahisoang ke EE le cocaine e ka tšoana kapa ea fapana ho ea ka libaka tsa boko le mofuta oa sele.
LITLHAHISO:
Re sebelisitse litoeba ho hlahisa protheine ea eGFP ho li-neuron tsa D1 receptoritive (D1R (+)) ho tseba hore na ΔFosB e hlahisoang ke li-ente tsa EE kapa tsa cocaine (5X15mg / kg) e tla ba teng ka bongata bo ikhethileng ba li-neuron libakeng tse 'maloa tse tlase tsa striatum. le cortex ea pele.
LIKOTSO:
Re fumane hore: ho pepesetsoa hoa XEUMX) ho kenyelletsa ts'ebetso ea ts'ebeliso ea koae, e netefatsang seo re se fumaneng nakong e fetileng; 1) ho pepeseha hoa EE ka bo eona ho eketsa ho bokellana ha ΔFosB haholo ho D2R (-) lisele tse karolong ea khetla ea li-nucleus accumbens (NAc) le dorsal striatum (DSt), athe NAc Core, ΔFosB e ipokella ka bobeli D1R (+ ) le li-neuron tsa D1R (-); 1) tikolohong e tloaelehileng (litoeba), litoeba tsa koae li etsa hore ho bokelloe ulationFosB ka mokhoa o ikhethileng liseleng tsa D3R (+) ho NAc, DSt le infralimbic cortex; 1) litlamorao tsa EE le koae ka ho bokellana ha ΔFosB li ne li thibetsoe ka ho kopantsoe ha tsona.
CONCLUSIONS:
Ka kakaretso, liphetho tsena li fana ka maikutlo a hore phokotso ea ts'ebetso ea EE e bakiloeng ke litla-morao tsa cocaine e kanna ea hlaha litlamorao tse peli tse fapaneng ho ΔFosB lits'ebetsong tsa methapo ea methapo e bohareng ea methapo ea methapo e tsamaeang ka kotloloho.
LINKOTSO: Tikoloho e ntlafalitsoeng; maikutlo a boits'oaro; koae; li-neuron tse bohareng le tse bohareng; ΔFosB
PMID: 27815415
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