Ho lemalla Moferefere. 2019 Aug 1: e12814. Doi: 10.1111 / adb.12814.
van de Wetering R1, Schenk S1.
inahaneloang
Ho pepesetsoa lithethefatsi khafetsa ho etsa hore ho be le liphetoho tse ngata tse phetoang, tseo tse ling tsa tsona e bileng teng tlhabollo ea ts'ebeliso ea lithethefatsi. Morero oa bohlokoa oa ho etsa lipatlisiso tsa bokhoba ba tai chi ke ho khetholla liphetoho tse ka fetolang phetoho ea tšebeliso ea lithethefatsi ho isa lithethefatsing. Ho bokellana ho sa feleng ha karolo ea phetisetso, ∆FosB, kamora ho pepesetsoa lithethefatsi khafetsa ho fana ka mokhoa oa ho fihlela sepheo sena. Liteko li entsoe ka likhoto tsa monna tse holofetseng tsa thobalano Sprague-Dawley. Litlamorao tsa boits'oaro bo pharaletseng ba 3,4-methylenedioxymethamphetamine (MDMA) mabapi le litekanyetso tsa immunohistochemical tsa ho bokellana ha ∆FosB libakeng tsa boko ba 12 li ne li bapisoa le sehlopha se laoloang, sa lithethefatsi. Lihlopha tse ling li ile tsa etsoa pele ke MDMA (0.0 kapa 10.0 mg / kg, ip, hang ka letsatsi bakeng sa matsatsi a 5), le phello ea activomotor-activating ea MDMA (200 μg / side) microinjected bilaterally libakeng tsa boko tse khethiloeng motheong oa ∆FosB Liphetho li ile tsa khethoa hamorao. Tsamaiso ea MDMA e ile ea eketsa haholo polelo ea ∆FosB ka har'a nucleus e bokellanang mantlha, ventromedial le dorsomedial caudate-putamen, anterior cingulate, prelimbic, infralimbic, and orbitof Pambal cortex, le bobeli le bohareng ba basystdala, empa eseng ka hare ho patrolatal kapa dorsolateral caud putamen. Keketseho ea khetla ea li-nucleus accumbens e ne e le ngata empa e ne e se bohlokoa ho latela khalemelo ea lipalo bakeng sa lipapiso tse ngata. Phekolo ea MDMA e ntlafalitse hyperactivity e hlahisitsoeng ke MDMA ha e tsamaisoa feela ka har'a li-nucleus accumbens kapa medial, empa eseng ea morao-rao, ea caudate-putamen, e bonts'a sephetho sa ∆FosB. Lintlha tsena li bapisoa hantle le liphetho tse latelang khafetsa ho pepesetsoa lithethefatsi tse ling tsa tlhekefetso mme li ts'ehetsa mohopolo oa liphetoho tse tloaelehileng tsa neuroplastic kamora ho pepesetsoa lithethefatsi khafetsa.
LINKOTSO: MDMA; temallo; phetisetso e matla; infusion ea lehae; boits'oaro; ΔFosB
PMID: 31373119
DOI: 10.1111 / adb.12814
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