Likhohlano tsa ho kopanela liphate ka likarabo tse susumelletsang batho ho ja mafura a li-hamsters tsa Syria (2015)

Basali ba na le menyetla e mengata ho feta banna ea ho bonts'a mathata a susumetsang (mohlala, anhedonia le matšoenyeho) ka likhetho tse fokolang tsa kalafo, le ho fetisa "lijo tsa boiketlo" tse mafura a mangata ho ntlafatsa litšitiso tse susumetsang. Ka bomalimabe, litlatsetso tsa methapo ea kutlo bakeng sa liphapang tsa thobalano ka tšitiso ea ts'usumetso le likarabo tsa bona ho mafura a phepo ha li utloisisoe hantle. Ho thusa ho koala likheo tsa tsebo ea mantlha, re lekotse karabelo ea boits'oaro le methapo ea kutlo ho mafura a phepo ka mokhoa oa hamster oa boits'oaro bo susumetsang ba basali. Mabapi le matlo a boiketlo ba sechaba, karohano ea sechaba e fokolitse drive ea hedonic tekong e ncha ea boits'oaro, teko ea lipatlisiso tsa khetho ea moputso (RIP). Phekolo ea Fluoxetine kapa desipramine bakeng sa 21, empa eseng 7, matsatsi a ntlafalitse ts'ebetso ea liteko tsa RIP. Tlhaloso ea Pharmacologic tekong ena e bontšitsoe ka ho se arabele diazepam, tracazolate, propranolol, kapa naltrexone. Tekong ea likhohlano tsa ho fepa / tsa ho lekola tse amanang le khatello ea maikutlo (AFEC), karohano ea sechaba e ile ea mpefatsa latency ea ho ja lijo tse hlabosehang haholo tlasa maemo a khatello ea maikutlo, empa eseng ka masakeng a lapeng. Ho arohana sechabeng ho boetse ho fokotsa boima ba 'mele, ho ja lijo le ho ba le takatso e matla ha ho ntse ho phahamisoa tšebeliso ea chelete, e lekiloeng ke ts'ebetso ea "caloric" le "calorimetry" e sa tobang. Ho feta moo, phepo e sa foleng ea mafura a mangata e ntlafalitse likarabo tsa anhedonic le ho tšoenyeha ka karohano, haholoholo ho basali. Boemong ba tšusumetso bo susumetsang ba basali, basali, empa eseng banna, ba bonts'itse phokotso e amanang le khatello ea maikutlo e amanang le khatello ea maikutlo maemong a Creb1 mRNA le phokotso e amanang le anhedonia maemong a ΔFosb mRNA. E tsamaellana le litlamorao tsa eona tsa ho imeloa kelellong le khatello ea maikutlo ho boitšoaro, ho fepa mafura a mangata ho phahamisa li-accumbal Creb1 le maemo a ΔFosb mRNA ho basali feela. Letšoao le leng la moputso o phahameng, Tlr4 mRNA, le ile la phahamisoa ho basali ka ho fepa mafura a mangata. Liphetho tsena li bonts'a hore karohano ea sechaba ea li-hamsters e fana ka mofuta o mocha oa li-comorbid anhedonia tse itšetlehileng ka thobalano, matšoenyeho le anorexia, le CREB e ikhethileng, ΔFosB le TLR4. Ho feta moo, liphetho li tiisa tlhahlobo e ncha bakeng sa katleho e sa foleng ea ho imeloa kelellong.

Copyright © 2015 Elsevier Inc. Litokelo tsohle li bolokiloe.