Ho lemalla Moferefere. 2015 Nov 24. Doi: 10.1111 / adb.12330.
Gao P1, Limpens JH2, Spijker S3, Vanderschuren LJ2,4, Voorn P1.
inahaneloang
Phetoho ho tloha tloaelo ho ea ho ts'ebeliso e mpe ea lithethefatsi ho nahanoa hore e ka etsahala ka lebaka la ho ts'oaroa hoa lithethefatsi khafetsa ho lebisang ho liphetoho tse bang teng methapong ea boko e kenyang maikutlo le kelello. Motheong oa li-neuroadaptations tse joalo li fetoha liphetoho puong ea liphatsa tsa pele tsa lefutso (IEGs) tse kenelletseng molemong oa mongolo, polasetiki ea synaptic le ho saena lipakeng. Leha ho le joalo, ha ho tsejoehale hantle mabapi le hore na mekhoa ea polelo ea IEG e fetoha joang nakong ea boits'oaro bo telele ba lithethefatsi.
To hlahisa thuto, ka hona, a bapisa litlamorao tsa 10 le 60 ea ho itšireletsa ha koae le ho itlama ka polelo ea 17 IEGs libakeng tsa boko tse kenyelletsang boits'ebetsong, e leng dorsal striatum, ventral striatum le medial prefrontal cortex (mPFC).
Polelo e eketsehang ka mor'a ho itlhokofatsa ka koae e fumanoe bakeng sa 6 IEGs ka har'a dorsal le ventral striatum (c-fos, Mkp1, Fosb / ΔFosb, Egr2, Egr4, and Arc) le 10 IEGs ho MPFC (6 IEGs and SNGs in ASNNS dNBDS, ASNNXDEfs in ASBNSNFDS. , Homer1, Sgk1 le Rgs2). Tse hlano ho tsena tsa 10 IEG (Egr2, Fosb / ΔFosb, Bdnf, Homer1 le Jun) le Trkb ho mPFC li ile tsa amohela boikemelo ba nako e telele ba ho ipusa.
Habohlokoa, ha ho liphapang tse kholo tse fumanoeng pakeng tsa mekhoa ea polelo ea IEG kamora matsatsi a 10 kapa 60 ea ho itaola ka koae, ntle le Fosb / ΔFosb ho dorsal striatum le Egr2 ho mPFC, athe palo ea cocaine e fumanoeng ka nako e ngoe le e 'ngoe e ne e ka bapisoa le ho itaola ka nako e khuts'oanyane le ka nako e telele.
Liphetoho tsena tse tsitsitseng polelong ea IEG, ka hona li amahanngoa le boits'oaro bo tsitsitseng ba ho itaola ho fapana le kakaretso e felletseng ea koae. Kahoo, tšusumetso e tsitsitseng ea taolo ea IEG nakong ea boits'oaro ba nako e telele ea cocaine e ka tsosa liphetoho tsa neuroplastic tse tlamang ts'ebeliso e mpe ea lithethefatsi.
LINKOTSO: Ts'ebetso ea cocaine; dorsal striatum; liphatsa tsa lefutso tsa pele; preortal cortex; ventral striatum
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