Ho lemalla Moferefere. 2015 Sep;20(5):941-55. doi: 10.1111/adb.12223.
Vazquez-Sanroman D1, Leto K2,3, Cerezo-Garcia M4, Carbo-Gase M1, Sanchis-Segura C1, Carulli D2,3, Rossi F2,3, Miquel M1.
inahaneloang
Leha taba ea hore lintlha tse 'maloa li tšehelitse karolo ea "cerebellum" lipuisanong tse sebetsang ka mora ts'ebeliso ea nako e telele ea koae, sebopeho sena sa boko se ne se hlokomolohuoe ebile se qheletsoe ka thoko ho potolohang ke lithethefatsi tse lemalloang. Thutong e teng hona joale, re fuputse litlamorao tsa kalafo e sa foleng ea koae ka polasetiki ea limolek'hule le sebopeho ka har'a cerebellum, ho kenyelletsa BDNF, D3 dopamine receptors, ΔFosB, Glu2 AMPA receptor subunit, liphetoho tsa sebopeho ho Purkinje neurons mme, qetellong, tlhahlobo ea matlooa a li-perineuronal (PNNs) ka har'a li-neuron tsa "proion" tsa "mesal", ho tsoa ha vermis ea cerebellar. Maemong a liteko a hona joale ao kalafo ea koae e ileng ea phetoa ka makhetlo a mangata a lateloang ke nako ea ho khaotsa libeke tsa 1 le phephetso e ncha ea cocaine, liphetho tsa rona li bonts'itse hore cocaine e bakile kholo e kholo ea maemo a proBDNF le polelo ea eona ho Purkinje neurons, ka polelo ea BDNF e holileng tse sa fetoheng.
Hammoho le sena, litoeba tse phekoloang ka koae li bontšitse ntlafatso e kholo ea maemo a li-receptor a D3. Ka bobeli ΔFosB le AMPA receptor Glu2 subunit li ile tsa matlafatsoa ho liphoofolo tse tšoaroang ke koae. Prunning ea bohlokoa ho Purkinje dendrite arborization le phokotso ea boholo le segokanyipalo sa Purkinje boutons tse ikopanyang le li-neurons tse tebileng tsa cerebellar tse tsamaeang le keketseho e itšetlehileng ka koae ho proBDNF. Litlamorao tse amanang le cocoaine li supa ho senyeha hoa ts'ebetso ea "Purkinje", joalo ka ha ho bonts'oa ke ts'ebetso e tlase liseleng tsena.
Ntle le moo, menyetla ea ho nchafatsoa leha e le efe ho li-synkes tsa Purkinje e bonahala e fokotsehile ka lebaka la ho eketseha ha likarolo tsa matrix tsa extracellular ho li-PNN tse potolohileng methapo ea kutlo ea nyutlelie.
LINKOTSO: BDNF; cerebellum; koae; litoeba; sensitization; ΔFosB
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