Mol Medi. 2010 Aug;10(4):219-30.
mohloli o moholo
Lekala la Fishberg la Neuroscience le Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA.
inahaneloang
Bokhoba ba lithethefatsi bo tšoailoe ke liphetoho tsa nako e telele boits'oarong bo hlahisang, ka tsela e fapaneng, ho tloha liphatlalatsong tse fetotsoeng tsa mofuta oa liphatsa tsa lefutso kahare ho likarolo tse kang li-nucleus accumbens (NAc). Liphetoho tsena ho mongolo oa liphatsa tsa lefutso li hokahantsoe ke letoto le rarahaneng la liphetoho tsa histone tse potileng DNA tse bakang khatello kapa ts'ebetso ea polelo ea gene. Bopaki ba morao-rao bo supile khokahano ea phetoho ea polelo ea liphatsa tsa lefutso, e laoloang ke ntho e hatisang DeltaFosB, e fetolang sebopeho le tšebetso ea NAc seaplane sa li-spiny neurons ho laola boits'oaro bo ts'oanang le boits'oaro. Thutong ena, re tla tšohla khatelo-pele ea morao-rao kutloisisong ea rona ea molao oa chromatin ka koae, le litlamorao tsa taolo e joalo ho polasetiki e hlophisitsoeng le ts'ebetso ea eona e amanang le tšebeliso ea lithethefatsi.
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