Dopamine neurons sebakeng sa ventral tegmental mollo ka potlako linthong tsa bacha ho feta batho ba baholo (2012).

J Neurophysiol. 2012 Sep; 108 (6): 1620-30. Epub 2012 Jun 20.
 

mohloli o moholo

Dept. ea Psychology, Univ. ea Illinois ho la Chicago, Chicago, IL 60607. [imeile e sirelelitsoe].

inahaneloang

Nako ea bocha e ka ba nako ea ho lemalla lithethefatsi. Ho likhoto, mosebetsi o phahameng oa ho thunya oa ventral qhekella sebakeng seo (VTA) dopamine neurons e bolela sekoloto se ntlafalitsoeng sa bokhoba ba ho lemalla. Morero oa rona e ne e le ho bona hore na dopamine neurons ba mafolofolo ho feta lilemong tsa bocha ho feta ho batho ba baholo le ho hlahloba mekhoa e tlisoang ke phapang e amanang le lilemo. VTA dopamine neurons e lelekoa Kapele ho bacha ho feta ho batho ba baholo joalo ka ha ho lekantsoe le rekotara ea extracellular ea vivo. Dopamine Ho thunya ha neuron ho ka aroloa hore e be mese ea nonbursting (spikes e le 'ngoe) le ts'ebetso ea ho phatloha (lihlopha tsa li-spikes tse phahameng haholo). Ts'ebetso e seng ea nyatso e ne e phahame ho bacha lilemong ha e bapisoa le batho ba baholo. Liketsahalo tsa ho phatloha khafetsa li ne li sa fapana lipakeng tsa lilemo, empa ho phatloha ho ne ho le telele ho bacha ho feta ho batho ba baholo. Ho phahamisitsoe dopamine neuron e kenang mocha likhoto e ile ea boela ea bonoa litlalehong tse kentsoeng ka seleng lisekeng tsa bongoaneng tsa vivo Re sebelisa lirekoto tse felletseng tsa lisele, re fumane hore thepa ea "membrane" e sebetsang le e sebetsang e ne e tšoana ho theosa le lilemo. Meetso ea li-cation tsa li-Hyperpolarization-activated cation le liteishene tse fokolang tsa calcium tsa matla a potasiamo le tsona li ka bapisoa ho theosa le lilemo. Ha rea ​​fumana karohano ho dopamine D2-class autoreceptor sebetsa ho theosa le lilemo, le ha ho fokotseha hoa mantlha ho bacha ho hlahisitse ts'ebetso ea autoreceptor e sa sebetse hantle ho khutsisang. neurons. Kamora nako, melapo ea "li-receptor-mediated spontaneous" e thabisang ea "li-circynaptic" tsa maqhubu e etsahetse maemong a tlase ho batjha; GABA (A) maqhubu a li-inhibitory-Mediated spontaneous inhibitory postynaptic currents a etsahetse ka linako tse tlase le maemong a manyane ho banyane. Qetellong, VTA dopamine neurons mollo Kapele lilemong tsa bocha, ho ka etsahala hobane molumo oa GABA o eketseha joalo ka likhoto fihlella ho ba motho e moholo. Ho phahama hona ha sekhahla sa ho thunya nakong ea bocha ho tsamaisana le eona ho emela nako e tlokotsing ea ho theha lithethefatsi tsa lithethefatsi.