Bafuputsi ba fumana tahi ea epigenetic ho mafu a neuropsychiatric
"Mosebetsi oa rona o hlahisa lits'oants'o tse ncha tsa ho utloisisa mathata a methapo ea pelo," ho boletse Emiliana Borrelli oa UCI.
Ho se sebetse ha lets'oao la dopamine ho fetola haholo ts'ebetso ea liphatsa tsa lefutso tse ka bang 2,000 bokong ba bokapele ba bokong mme e kanna ea ba sesosa sa mathata a itseng a rarahaneng a methapo ea pelo, joalo ka schizophrenia, ho latela bo-rasaense ba UC Irvine
Phetoho ena ea epigenetic ea mosebetsi oa mofuta in lisele tsa boko ba amohelang neurotransmitter ena e bontšitsoeng ka lekhetlo la pele hore dopamine e fokola e ka ama boits'oaro bo fapaneng mesebetsi ea 'mele e laoloa ke prefrontal cortex.
Phuputso, e etelletsoeng pele ke Emiliana Borrelli, moprofesa oa UCI oa microbiology & molecular genetics, o hlaha marang-rang koranteng Molecular Psychiatry.
"Mosebetsi oa rona o hlahisa tse ncha tse isang kutloisisong ea mathata a methapo ea pelo," ho boletse Borrelli. “Ho bonahala liphatsa tsa lefutso tse neng li hokahane le schizophrenia li itšetlehile ka ho lokolloa ha dopamine libakeng tse itseng bokong. Ho thahasellisang ke hore phuputso ena e bontša hore maemo a fetotsoeng a dopamine a ka fetola tšebetso ea liphatsa tsa lefutso ka mekhoa ea epigenetic leha ho se na liphatsa tsa lefutso tsa DNA. ”
Dopamine ke neurotransmitter e sebetsang ka har'a likarolo tse itseng tsa boko ho thusa ho tsamaisa mesebetsi ho tloha ho motsamao ho isa ho maikutlo. Liphetoho tsamaisong ea dopaminergic li tsamaellana le ho senyeha ha kelello, motor, lihormone le maikutlo. Ho fetela ho ho saena ha dopamine, ho etsa mohlala, ho fumanoe e le sesosa sa matšoao a lefu la neuropsychiatric.
Borrelli le sehlopha sa hae ba ne ba batla ho utloisisa hore na ho tla etsahala eng haeba ho thibeloa ho saena ka dopamine ho sitisoa. Ho etsa sena, ba ile ba sebelisa litoeba tse neng li haella dopamine li-receptors ho li-neuron tsa midbrain, tse ileng tsa ama haholo dopamine synthesis le tokollo.
Bafuputsi ba fumane hore phetoho ena ea phetoho ea methapo ea methapo e fetotsoe haholo liphatseng tsa lefutso ho li-neuron tse amohelang dopamine libakeng tsa khubung ea bokong, ka kotloloho mokokotlong oa pele. Borrelli o itse ba bone ho fokotseha ho makatsang ha mefuta ea lipapatso tsa mofuta oa 2,000 sebakeng sena, hammoho le keketseho e pharalletseng ea liphetoho tsa liprotheine tsa mantlha tsa DNA tse bitsoang histones - haholoholo tse amanang le ts'ebetso ea gene e fokotsehileng.
Borrelli o boetse a hlokometse hore ts'ebetso ea dopamine receptor-ikiwa e lebisitse ho boits'oaro bo kang ba kelello maikutlong a feto-fetohang le hore kalafo ea nako e telele le activator ea dopamine e khutlisitse ho supa kamehla, e supa mokhoa o mong o ka bang oa kalafo.
Bafuputsi ba ntse ba tsoela pele ka mosebetsi oa bona ho fumana leseli le eketsehileng liphatseng tsa lefutso tse fetotsoeng ke lets'oao le sa sebetseng la dopamine.
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