La 20 Mphalane, 2014 ho tsa bongaka /
Ka nako ea lilemo tse 10, ho bile le liketsahalo tse mpe tsa lithethefatsi tse 1,580 United States le linaheng tse ling tse 21 tse bonts'ang mathata a taolo e bakang bakuli, ho kenyeletsoa le 628 ea ho becha ha methapo ea maoto, linyeoe tse 465 tsa khatello ea maikutlo le linyeoe tse 202 tsa ho reka ka thata. Kakaretso e kenyelletsa liketsahalo tsa 710 tse amanang le lithethefatsi tsa dopamine receptor agonist (tse sebelisoang ho phekola lefu la Parkinson, syndrome ea leoto le sa foleng le hyperprolactinemia) le liketsahalo tse 870 bakeng sa lithethefatsi tse ling.
Mathata a ho se laolehe a sa tloaelehang le a matla, a kenyeletsang papali ea papali ea chelete, hypersexuality le mabenkele a qobelloang, ho tlalehiloe ho bakuli ba sebelisang lithethefatsi tsa dopamine receptor agonist. Dopamine receptor agonist lithethefatsi, e leng activate dopamine li-receptors, li ngotsoe khafetsa 'me ho bile le litlhaloso tse fetotsoeng tsa limilione tse 2.1 lekoteng la bone la 2012.
Bangoli ba ile ba sekaseka litlaleho tse bohloko tsa ketsahalo ea lithethefatsi bakeng sa lithethefatsi tse tšeletseng tsa dopamine receptor agonist tse rekisoang US. lithethefatsi litlaleho tsa ketsahalo ho tloha ka 2003 ho isa ho 2012 li nkile polokelongtshedimosetso e mpe ea Setsi sa Tlaleho ea Liketsahalo tse Ntle tsa US Food and Drug Administration.
Litlaleho tsa 710 (karolo ea 44.9 lekholong) ea lithethefatsi tsa dopamine receptor agonist li etsahetse hara bakuli ba lilemo tse 55 le ba neng ba le boholo ba banna (liperesente tse 65.8). Hoo e ka bang halofo ea liketsahalo tse tlalehiloeng li etsahetse United States. Meriana e ne e laetsoe haholo bakeng sa lefu la Parkinson liketsahalong tse 438 (karolo ea 61.7 lekholong) le lefu la leoto le se nang phomolo liketsahalong tse 169 (liperesente tse 23.8).
“Seo re se fumaneng se tiisa le ho atolosa bopaki ba hore lithethefatsi tsa dopamine receptor agonist li amana le mathata a tebileng a ho laola maikutlo; mekhatlo e ne e le bohlokoa, boholo ba litlamorao e ne e le kholo mme litlamorao li bonoe bakeng sa lithethefatsi tsohle tse tšeletseng tsa dopamine receptor agonist. … Hajoale, ha ho le e 'ngoe ea litlhare tsa dopamine receptor agonist tse amohetsoeng ke FDA tse nang le litemoso tse ngotseng ka monyetla oa nts'etsopele ea mathata a matla a ho laola maikutlo e le karolo ea tlhaiso-leseling eo ba fanang ka eona. Lintlha tsa rona, le tlhaiso-leseling e tsoang lithutong tsa pejana, li bonts'a tlhoko ea litemoso tsena tse hlahelletseng, "Thomas J. Moore, AB, oa Setsi sa Mekhoa e Sireletsehileng ea Phekolo ea Meriana, Alexandria, Va., Le basebetsi mmoho ba ngotse JAMA Kahare Meriana sehlooho.
Tlhalosong e amanang le ena, Joshua J. Gagne, Pharm.D., Sc.D., oa Brigham le Sepetlele sa Basali le Sekolo sa Bongaka sa Harvard, Boston, oa ngola: “Makasineng ena, Moore le basebetsi-'moho le eena ba hlahisa litholoana tse matla tsa tlhahlobo ea ho se lekane ho hlahloba kopano lipakeng tsa lithethefatsi tsa dopamine receptor agonist le boits'oaro bo sa tsitsang. … Bangoli ba sebelisitse tlhaiso-leseling ena ho bala palo e lekanyelitsoeng ea ho tlaleha (PRR) ea 277.6, ho bontša hore karolo ea litlaleho tsohle tse mpe tse amanang le boits'oaro bo potlakileng e ne e phahame makhetlo a 277.6 bakeng sa lithethefatsi tsa dopamine receptor agonist vs. lithethefatsi tse ling. ”
"Ka lebaka la mefokolo ea database ea FAERS [Setsi sa Ts'ebeliso ea Lijo le Lithethefatsi sa US] le tlhatlhobo e tsosang takatso ea Moore le basebetsi-'moho, ke kopano lipakeng tsa lithethefatsi tsa dopamine receptor agonist le mathata a taolo ea tšusumetso e kanna ea ba khokahano ea 'nete eseng feela mohlala data e sa reroang? Ka PRR e kholo e kanna ea fokotsoa ka ho ferekanya le bopaki bo hlahang bo tsoang mehloling e meng, menyetla ea khokahano ea lisosa e phahame, "Gagne o phethela.
Tlhalosong e 'ngoe e amanang le ena, Howard D. Weiss, MD, oa Sepetlele sa Sinai sa Baltimore, le Gregory M. Pontone, MD, oa Sekolo sa Bongaka sa Johns Hopkins University, Baltimore, ba ngola: "Tlaleho ea Moore le basebetsi-'moho tokollong ena e totobatsa Mekhatlo e pakeng tsa mathata a ho laola maikutlo le lithethefatsi tsa agonist tsa dopamine receptor. ”
“Tlaleho e hlahisa lipotso tse 'maloa? Lithethefatsi tsa dopamine receptor agonist li baka mekhoa e sa tloaelehang e bonoang ho bakuli ba nang le khatello ea taolo ea tšusumetso? Hobaneng ha bakuli ba bang, empa eseng ba bang, ba hlaolela mathata aa? Hobaneng mokhatlo o sa ka oa amoheloa kapele? ” bangoli ba tsoelapele.
"Ka bokhutšoanyane, lingaka li fetisitse molemo le ho nyenyefatsa likotsi tse amanang le ts'ebeliso ea lithethefatsi tsa dopamine receptor agonist ho bakuli ba nang le lefu la Parkinson. Ho ea ka rona, meriana ena e lokela ho sebelisoa hanyane ka hanyane le ka tlhokomeliso e kholo, e shebane haholo le litlamorao tse ka bang teng tsa boitšoaro le ho laola maikutlo. "
Boitsebiso bo eketsehileng: JAMA Medi Med. E hatisitsoe Inthaneteng October 20, 2014. DOI: 10.1001 / jamainternmed.2014.5262
JAMA Medi Med. E hatisitsoe Inthaneteng October 20, 2014. DOI: 10.1001 / jamainternmed.2014.3270
JAMA Medi Med. E hatisitsoe Inthaneteng October 20, 2014. DOI: 10.1001 / jamainternmed.2014.4097
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