Kakaretso: Cocaine le sucrose neuron ensembles ka har'a li-nucleus accumbens hangata ha li kopane.
Source: University of Wyoming
Nucleus accumbens bokong e bapala karolo ea mantlha potolohong ea moputso oa kotsi. Ts'ebetso ea bona e thehiloe haholo ho li-neurotransmitters tse tharo tsa bohlokoa: dopamine, e khothalletsang takatso; serotonin, eo litlamorao tsa eona li kenyeletsang ho kgora le ho thibela mmele; le glutamate, e tsamaisang boits'oaro bo tataisoang ke sepheo le likarabo mokhoeng o amanang le moputso le maemo.
Phuputsong e sebelisang litoeba tse fetotsoeng ka liphatsa tsa lefutso, setho sa lefapha la thuto ea lefapha la Wyoming se fumane hore li-nucleus tse bokelletsoeng tse sebelisoang ke tšebeliso ea k'hok'heine li fapane haholo le li-nucleus accumbens ensembles tse hapuoeng ke sucrose, kapa tsoekere ea tafoleng. Hobane li arohane, sena se hlahisa monyetla oa hore ts'ebeliso ea lithethefatsi e ka sebetsanoa ntle le ho ama ho ipapisa le bophelo ho batlang moputso.
Ana Clara Bobadilla o re: "Re netefalitse hore, sebakeng sa bokellane, sebaka sa mantlha sa boko sa ho sebetsana le moputso, li-neuronal ensembles - marang-rang a fokolang a li-neuron a sebelisitsoeng ka nako e le ngoe - a khethehile ka moputso, 'me li-sucrose le li-ensembles tsa cocaine ha li felle." motlatsi oa moprofesa oa UW Sekolong sa Pharmacy le WWAMI (Washington, Wyoming, Alaska, Montana le Idaho) Lenaneo la Thuto ea Bongaka.
Bobadilla ke mongoli ea ka sehloohong oa pampiri, e bitsoang "Cocaine le Sucrose Meputso e Fumana Batho ba Batlang ho Batla ka Nucleus Accumbens Core," e phatlalalitsoeng tokollong ea la 28 Loetse. Molecular Psychiatry. Koranta e phatlalatsa mosebetsi o reretsoeng ho hlakisa mekhoa ea likokoana-hloko e bakang mathata a kelello le kalafo. Ho hatisoa haholo lithutong tse sebetsanang le lipatlisiso tsa pele ho kalafo le tsa bongaka, ho kenyeletsoa lithuto tse fumanehang liseleng, limolek'hule, likhokahanyo, litleliniki, litšoantšo le psychopharmacology.
Bobadilla o ile a etsa lipatlisiso ha a ntse a phethela mosebetsi oa hae oa morao-rao Univesithing ea Bongaka ea South Carolina. Morero o qalile bohareng ba 2017. Mofani e mong oa thuto ena o se a sebetsa Univesithing ea Colorado Anschutz Medical Campus.
Hajoale, ts'ebetso ea ho hira ka har'a sehlopha ka seng e ikhethileng ea moputso ha e tsejoe. Leha ho le joalo, a sebelisa lisebelisoa tsa baeloji ea limolek'hule, Bobadilla o ile a khona ho tseba hore na ke lisele tsa mofuta ofe tse ileng tsa hiroa ka har'a sehlopha sa cocaine le sa sucrose.
Lisele tsena li tsejoa e le GABAergic projection neurons, eo hape e bitsoang li-spiny neurons tse mahareng. Li na le liperesente tsa 90 ho 95 lekholong ea baahi ba methapo ea kutlo le li-nucleus accumbens. Li-neuron tsena tse mahareng tse hlaselang li hlahisa dopamine D1 kapa receptor ea D2.
Phuputso e bonts'itse li-ensembles tsa sucrose le cocaine tse hiriloeng haholo li-receptor tsa D1 tse hlalosang li-spiny neurons tse mahareng. Liphetho tsena li tsamaellana le kutloisiso e akaretsang lebaleng ea hore ts'ebetso ea tsela ea D1 e khothaletsa ho batla meputso, ha ts'ebetso ea tsela ea D2 e ka lebisa tlhokomelong kapa ea fokotsa ho batla, Bobadilla o re.
Phuputso e bonts'itse li-ensembles tsa sucrose le cocaine tse hiriloeng haholo li-receptor tsa D1 tse hlalosang li-spiny neurons tse mahareng. Setšoantšo se sebakeng sa sechaba
“Ho batho, lithethefatsi ha li sebelisoe hangata. Boholo ba rona re na le bophelo bo rarahaneng ho kenyelletsa mehloli e mengata ea meputso ea lithethefatsi, joalo ka lijo, metsi, tšebelisano ea sechaba kapa thobalano, ”ho hlalosa Bobadilla. “Joaloka lithethefatsi, meputso ena ea khanna ebile e susumetsa boitšoaro ba rona khafetsa. Moetso o kopaneng oa cocaine le sucrose o sebelisitsoeng thutong ena o re lumella ho khetholla sehlopha se ikhethileng sa cocaine kamora litoeba tse nang le boiphihlelo ba mofuta oa mofuta o mong oa moputso.
"Ke mofuta o rarahaneng haholo, empa o haufi haholo le se etsahalang ho batho ba nang le mathata a ts'ebeliso ea lithethefatsi, ba loantšang meputso ea tlholisano letsatsi le letsatsi," oa eketsa.
Hona joale Bobadilla o shebane le potso ea hore na lisele li hiroa joang ka bongata. Ntle le moo, o ikemiselitse ho araba potso e 'ngoe ea bohlokoa lipatlisisong tsa bokhoba ba tahi: na mekhoa e ts'oanang ea marang-rang e tšehetsa ho batla meputso eohle ea lithethefatsi.
O re: "Lithethefatsi tsohle tsa tlhekefetso li na le menyetla e mengata ea ho khutlela morao." “Leha ho le joalo, sehlopha ka seng sa lithethefatsi tse lemalloang se bontša litlhare tse fapaneng tse fapaneng le polasetiki ea synaptic. Hona joale re ntse re batlisisa hore na thepa e khethehileng ea ensembles e ka hlalosa phapang ena. ”
Lithuso: Thutong e ne e tšehelitsoe ka chelete ke moeletsi oa Bobadilla ka mor'a bongaka, Peter Kalivas, moprofesa le molulasetulo oa methapo ea kutlo Univesithing ea Bongaka ea South Carolina, le ke Moputso oa Naha oa Bophelo oa Tsela ea Boipuso Bobadilla o fumanoeng mathoasong a 2019.
Mabapi le litaba tsena tsa lipatlisiso tsa neuroscience
mohloli o moholo: University of Wyoming
Contact: Ana Clara Bobadilla - Univesithi ea Wyoming
setšoantšo: Setšoantšo se sebakeng sa sechaba
Patlisiso ea mantlha: E koetsoe.
"Cocaine le meputso ea sucrose li bokella mefuta e fapaneng ea li-ensembles tse bokellaneng ba mantlha”Ea Ana-Clara Bobadilla, Eric Dereschewitz, Lucio Vaccaro, Jasper A. Heinsbroek, Michael D. Scofield le Peter W. Kalivas. Molecular Psychiatry
inahaneloang
Cocaine le meputso ea sucrose li bokella mefuta e fapaneng ea li-ensembles tse bokellaneng ba mantlha
Ho batla moputso o laoloang hampe ke karolo ea mantlha ea ts'ebeliso ea lithethefatsi. Phuputso ea morao-rao e bonts'a hore liphihlelo tse putsoang tse amanang le lithethefatsi li etsa hore ts'ebetso e lumellanang ea li-neurone tse ngata tse fumanehang li-nucleus accumbens tse hokahantsoeng le maemo a amanang le moputso. Mona re tseba ka botlalo li-neurone tse ikhethileng tse hahiloeng ka boiphihlelo tse hokahaneng le boits'oaro. Re boetse re araba potso ea hore na lithethefatsi tse lemalloang li sebelisa marang-rang a bokelloang ke meputso ea tlhaho ka ho lekola li-ensembles tse amanang le cocaine le sucrose ka har'a toeba e le 'ngoe. Re ne re sebelisa FosCreERT2 / +/ Ai14 litoeba tsa transgenic ho tšoaea lisele tse ts'oeroeng ke k'hok'heine le ho batla ho ts'oaroa ha sucrose. Re tšoaile ~ 1% ea li-neurone karolong e ka sehloohong ea li-accumbens (NAcore) e sebelisitsoeng nakong ea ho batla koae kapa sucrose. Boholo ba lisele tse tšoailoeng ka har'a li-ensembles tse neng li batla e ne e le li-D1-MSN, 'me li sebelisitsoe ka kotloloho nakong ea ho batla, eseng nakong ea ho fela kapa ha litoeba li lula ka ntlong ea lehae. Ho bapisa li-ensembles tse fapaneng tse ikhethileng ka har'a panya e le 'ngoe, re sebelisitse k'hok'heine e kopaneng le sucrose protocol ea boits'oaro e lumellang moputso o ikhethileng. Re sebelisa mohlala ona, re fumane phapang ea ~ 70% lipakeng tsa lisele tse etsang k'hok'heine- ha e bapisoa le sehlopha se batlang sucrose. Ho theha k'hok'heine e bokella sehlopha sa li-neuron tsa NAcore haholo tse arohaneng le li-neuron tse kenngoeng ka har'a kh'outu e kopaneng bakeng sa ho batla sucrose e fana ka maikutlo a mofuta o hlophisitsoeng hantle oa li-ensembles. Liphuputso li lumella tlhahlobo e tsoelang pele ea mekhoa e fetolang matlafatso a thehiloeng ho moputso ho ba ts'ebetsong e mpe ea lithethefatsi.
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